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Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Box, Philip C, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Emmons, Amanda, Ford, Alison J, Holmes, Duncan S, Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E, Mann, Inderjit S, McLay, Iain M, Morrison, Valerie S, Mutch, Peter J, Smith, Claire E, Tomlin, Paula
Published in Journal of medicinal chemistry (10.06.2010)

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Discovery of a Rapidly Metabolized, Long-Acting beta(2) Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

Discovery of a Rapidly Metabolized, Long-Acting beta(2) Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

by Procopiou, Panayiotis A., Barrett, Victoria J., Biggadike, Keith, Butchers, Peter R., Craven, Andrew, Ford, Alison J., Guntrip, Stephen B., Holmes, Duncan S., Hughes, Sara C., Jones, Anne E., Looker, Brian E., Mutch, Peter J., Ruston, Mark, Needham, Deborah, Smith, Claire E.
Published in Journal of medicinal chemistry (09.01.2014)

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Journal Article

Discovery of a Rapidly Metabolized, Long-Acting β2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

Discovery of a Rapidly Metabolized, Long-Acting β2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

by Procopiou, Panayiotis A, Barrett, Victoria J, Biggadike, Keith, Butchers, Peter R, Craven, Andrew, Ford, Alison J, Guntrip, Stephen B, Holmes, Duncan S, Hughes, Sara C, Jones, Anne E, Looker, Brian E, Mutch, Peter J, Ruston, Mark, Needham, Deborah, Smith, Claire E
Published in Journal of medicinal chemistry (09.01.2014)

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Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

Synthesis and Structure−Activity Relationships of Long-acting β2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Edney, Dean D, Field, Rita N, Ford, Alison J, Guntrip, Stephen B, Looker, Brian E, McLay, Iain M, Monteith, Michael J, Morrison, Valerie S, Mutch, Peter J, Richards, Stephen A, Sasse, Rosemary, Smith, Claire E
Published in Journal of medicinal chemistry (23.04.2009)

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Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity

Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A(2A) receptor agonist and adenosine A(3) receptor antagonist activity

by Bevan, Nicola, Butchers, Peter R, Cousins, Rick, Coates, Jill, Edgar, Emma V, Morrison, Val, Sheehan, Michael J, Reeves, Julian, Wilson, David J
Published in European journal of pharmacology (14.06.2007)

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Journal Article

Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A2A receptor agonist and adenosine A3 receptor antagonist activity

Pharmacological characterisation and inhibitory effects of (2R,3R,4S,5R)-2-(6-amino-2-{[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]amino}-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol, a novel ligand that demonstrates both adenosine A2A receptor agonist and adenosine A3 receptor antagonist activity

by Bevan, Nicola, Butchers, Peter R., Cousins, Rick, Coates, Jill, Edgar, Emma V., Morrison, Val, Sheehan, Michael J., Reeves, Julian, Wilson, David J.
Published in European journal of pharmacology (14.06.2007)

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The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating hydantoin or uracil rings

The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating hydantoin or uracil rings

by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Butchers, Peter R., Conroy, Richard, Emmons, Amanda, Ford, Alison J., Jeulin, Séverine, Looker, Brian E., Lunniss, Gillian E., Morrison, Valerie S., Mutch, Peter J., Perciaccante, Rossana, Ruston, Mark, Smith, Claire E., Somers, Graham
Published in Bioorganic & medicinal chemistry (15.07.2011)

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Synthesis and Structure-Activity Relationships of Long-acting beta(2) Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Synthesis and Structure-Activity Relationships of Long-acting beta(2) Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Box, Philip C., Butchers, Peter R., Coe, Diane M., Conroy, Richard, Emmons, Amanda, Ford, Alison J., Holmes, Duncan S., Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E., Mann, Inderjit S., McLay, Iain M., Morrison, Valerie S., Mutch, Peter J., Smith, Claire E., Tomlin, Paula
Published in Journal of medicinal chemistry (10.06.2010)

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Journal Article

Discovery of a Rapidly Metabolized, Long-Acting β 2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

Discovery of a Rapidly Metabolized, Long-Acting β 2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

by Procopiou, Panayiotis A., Barrett, Victoria J., Biggadike, Keith, Butchers, Peter R., Craven, Andrew, Ford, Alison J., Guntrip, Stephen B., Holmes, Duncan S., Hughes, Sara C., Jones, Anne E., Looker, Brian E., Mutch, Peter J., Ruston, Mark, Needham, Deborah, Smith, Claire E.
Published in Journal of medicinal chemistry (09.01.2014)

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Journal Article

Synthesis and Structure-Activity Relationships of Long-acting beta(2) Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

Synthesis and Structure-Activity Relationships of Long-acting beta(2) Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Butchers, Peter R., Coe, Diane M., Conroy, Richard, Edney, Dean D., Field, Rita N., Ford, Alison J., Guntrip, Stephen B., Looker, Brian E., McLay, Iain M., Monteith, Michael J., Morrison, Valerie S., Mutch, Peter J., Richards, Stephen A., Sasse, Rosemary, Smith, Claire E.
Published in Journal of medicinal chemistry (23.04.2009)

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Journal Article

The discovery of long-acting saligenin beta sub(2 adrenergic receptor agonists incorporating hydantoin or uracil rings)

The discovery of long-acting saligenin beta sub(2 adrenergic receptor agonists incorporating hydantoin or uracil rings)

by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Butchers, Peter R, Conroy, Richard, Emmons, Amanda, d, Alison J, Jeulin, Severine, Looker, Brian E, Lunniss, Gillian E, Morrison, Valerie S, Mutch, Peter J, Perciaccante, Rossana, Ruston, Mark, Smith, Claire E, Somers, Graham, Xepfqmjboitfns-Sanmltnesa-N, InChiKey
Published in Bioorganic & medicinal chemistry (15.07.2011)

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Journal Article

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Box, Philip C., Butchers, Peter R., Coe, Diane M., Conroy, Richard, Emmons, Amanda, Ford, Alison J., Holmes, Duncan S., Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E., Mann, Inderjit S., McLay, Iain M., Morrison, Valerie S., Mutch, Peter J., Smith, Claire E., Tomlin, Paula
Published in Journal of medicinal chemistry (10.06.2010)

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Journal Article

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

by Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Butchers, Peter R., Coe, Diane M., Conroy, Richard, Edney, Dean D., Field, Rita N., Ford, Alison J., Guntrip, Stephen B., Looker, Brian E., McLay, Iain M., Monteith, Michael J., Morrison, Valerie S., Mutch, Peter J., Richards, Stephen A., Sasse, Rosemary, Smith, Claire E.
Published in Journal of medicinal chemistry (23.04.2009)

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Journal Article

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach

by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Box, Philip C, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Emmons, Amanda, Ford, Alison J, Holmes, Duncan S, Horsley, Helen, Kerr, Fern, Li-Kwai-Cheung, Anne-Marie, Looker, Brian E, Mann, Inderjit S, McLay, Iain M, Morrison, Valerie S, Mutch, Peter J, Smith, Claire E, Tomlin, Paula
Published in Journal of medicinal chemistry (10.06.2010)

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Journal Article

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups

by Procopiou, Panayiotis A, Barrett, Victoria J, Bevan, Nicola J, Biggadike, Keith, Butchers, Peter R, Coe, Diane M, Conroy, Richard, Edney, Dean D, Field, Rita N, Ford, Alison J, Guntrip, Stephen B, Looker, Brian E, McLay, Iain M, Monteith, Michael J, Morrison, Valerie S, Mutch, Peter J, Richards, Stephen A, Sasse, Rosemary, Smith, Claire E
Published in Journal of medicinal chemistry (23.04.2009)

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Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol

Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol

by Nials, Anthony T., Ball, Douglas I., Butchers, Peter R., Coleman, Robert A., Humbles, Alison A., Johnson, Malcolm, Vardey, Christopher J.
Published in European journal of pharmacology (14.01.1994)

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The discovery and synthesis of highly potent, A 2a receptor agonists

The discovery and synthesis of highly potent, A 2a receptor agonists

by Keeling, Suzanne E., Albinson, F.David, Ayres, Barry E., Butchers, Peter R., Chambers, C.Lynn, Cherry, Peter C., Ellis, Frank, Ewan, George B., Gregson, Michael, Knight, John, Mills, Keith, Ravenscroft, Paul, Reynolds, Linda H., Sanjar, Shahin, Sheehan, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.02.2000)

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