Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor γ Coactivator 1β and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice
Yang, Ruojing, Wilcox, Denise M., Haasch, Deanna L., Jung, Paul M., Nguyen, Phong T., Voorbach, Martin J., Doktor, Stella, Brodjian, Sevan, Bush, Eugene N., Lin, Emily, Jacobson, Peer B., Collins, Christine A., Landschulz, Katherine T., Trevillyan, James M., Rondinone, Cristina M., Surowy, Terry K.
Published in The Journal of biological chemistry (03.08.2007)
Published in The Journal of biological chemistry (03.08.2007)
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Structure-Activity Relations of Successful Pharmacologic Chaperones for Rescue of Naturally Occurring and Manufactured Mutants of the Gonadotropin-Releasing Hormone Receptor
Janovick, Jo Ann, Goulet, Mark, Bush, Eugene, Greer, Jonathan, Wettlaufer, David G, Conn, P Michael
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2003)
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Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists
Xin, Zhili, Serby, Michael D, Zhao, Hongyu, Kosogof, Christi, Szczepankiewicz, Bruce G, Liu, Mei, Hutchins, Charles W, Sarris, Kathy A, Hoff, Ethan D, Falls, H. Douglas, Lin, Chun W, Ogiela, Christopher A, Collins, Christine A, Brune, Michael E, Bush, Eugene N, Droz, Brian A, Fey, Thomas A, Knourek-Segel, Victoria E, Shapiro, Robin, Jacobson, Peer B, Beno, David W. A, Turner, Teresa M, Sham, Hing L, Liu, Gang
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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Journal Article
2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists
Serby, Michael D., Zhao, Hongyu, Szczepankiewicz, Bruce G., Kosogof, Christi, Xin, Zhili, Liu, Bo, Liu, Mei, Nelson, Lissa T. J., Kaszubska, Wiweka, Falls, H. Douglas, Schaefer, Verlyn, Bush, Eugene N., Shapiro, Robin, Droz, Brian A., Knourek-Segel, Victoria E., Fey, Thomas A., Brune, Michael E., Beno, David W. A., Turner, Theresa M., Collins, Christine A., Jacobson, Peer B., Sham, Hing L., Liu, Gang
Published in Journal of medicinal chemistry (20.04.2006)
Published in Journal of medicinal chemistry (20.04.2006)
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Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
Souers, Andrew J., Gao, Ju, Wodka, Dariusz, Judd, Andrew S., Mulhern, Mathew M., Napier, James J., Brune, Michael E., Bush, Eugene N., Brodjian, Sevan J., Dayton, Brian D., Shapiro, Robin, Hernandez, Lisa E., Marsh, Kennan C., Sham, Hing L., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Nonpeptide Luteinizing Hormone-Releasing Hormone Antagonists Derived from Erythromycin A: Design, Synthesis, and Biological Activity of Cladinose Replacement Analogues
Randolph, John T, Waid, Philip, Nichols, Charles, Sauer, Daryl, Haviv, Fortuna, Diaz, Gilbert, Bammert, Gary, Besecke, Leslie M, Segreti, Jason A, Mohning, Kurt M, Bush, Eugene N, Wegner, Craig D, Greer, Jonathan
Published in Journal of medicinal chemistry (26.02.2004)
Published in Journal of medicinal chemistry (26.02.2004)
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Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity
Judd, Andrew S., Souers, Andrew J., Wodka, Dariusz, Zhao, Gang, Mulhern, Mathew M., Iyengar, Rajesh R., Gao, Ju, Lynch, John K., Freeman, Jennifer C., Falls, H. Douglas, Brodjian, Sevan, Dayton, Brian D., Reilly, Regina M., Gintant, Gary, Limberis, James T., Mikhail, Ann, Leitza, Sandra T., Houseman, Kathryn A., Diaz, Gilbert, Bush, Eugene N., Shapiro, Robin, Knourek-Segel, Victoria, Hernandez, Lisa E., Marsh, Kennan C., Sham, Hing L., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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In vitro Optimization of Structure Activity Relationships of Analogues of A‐331440 Combining Radioligand Receptor Binding Assays and Micronucleus Assays of Potential Antiobesity Histamine H3 Receptor Antagonists
Hancock, Arthur A., Diehl, Marilyn S., Faghih, Ramin, Bush, Eugene N., Krueger, Kathleen M., Krishna, Gopala, Miller, Thomas R., Wilcox, Nguyen, Phong, Pratt, John K., Cowart, Marlon D., Esbenshade, Timothy A., Jacobson, Peer B.
Published in Basic & clinical pharmacology & toxicology (01.09.2004)
Published in Basic & clinical pharmacology & toxicology (01.09.2004)
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Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice
Bush, Eugene N, Shapiro, Robin, Brune, Michael E, Knourek-Segel, Victoria E, Droz, Brian A, Fey, Thomas, Lin, Emily, Jacobson, Peer B
Published in Endocrine (01.04.2006)
Published in Endocrine (01.04.2006)
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Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: The effects of chirality on substituted indan-1-ylamines
Souers, Andrew J., Iyengar, Rajesh R., Judd, Andrew S., Beno, David W.A., Gao, Ju, Zhao, Gang, Brune, Michael E., Napier, James J., Mulhern, Mathew M., Lynch, John K., Freeman, Jennifer C., Wodka, Dariusz, Chen, Chong J., Falls, H. Doug, Brodjian, Sevan, Dayton, Brian D., Diaz, Gilbert J., Bush, Eugene N., Shapiro, Robin, Droz, Brian A., Knourek-Segel, Victoria, Hernandez, Lisa E., Marsh, Kennan C., Reilly, Regina M., Sham, Hing L., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist
HANCOCK, Arthur A, BENNANI, Youssef L, JIA BAO PAN, SHAPIRO, Robin, WITTE, David G, YAO, Betty B, BUSH, Eugene N, ESBENSHADE, Timothy A, FAGHIH, Ramin, FOX, Gerard B, JACOBSON, Peer, KNOUREK-SEGEL, Victoria, KRUEGER, Kathleen M, NUSS, Merrill E
Published in European journal of pharmacology (08.03.2004)
Published in European journal of pharmacology (08.03.2004)
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Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists
Haviv, Fortuna, Fitzpatrick, Timothy D, Swenson, Rolf E, Nichols, Charles J, Mort, Nicholas A, Bush, Eugene N, Diaz, Gilbert, Bammert, Gary, Nguyen, A
Published in Journal of medicinal chemistry (01.02.1993)
Published in Journal of medicinal chemistry (01.02.1993)
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Pharmacological and endocrine characterization of A-198401, an orally active GnRH antagonist, in intact and castrate male rat models
Besecke, Leslie M., Diaz, Gilbert J., Segreti, Jason A., Mohning, Kurt M., Cybulski, Van A., Rao, Mira, Bush, Eugene N., Randolph, John T., Waid, Philip L., Haviv, Fortuna, Wegner, Craig D., Greer, Jonathan
Published in Drug development research (01.03.2001)
Published in Drug development research (01.03.2001)
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In vitro and in vivo Activities of Reduced-Size Antagonists of Luteinizing Hormone-Releasing Hormone
Haviv, Fortuna, Fitzpatrick, Timothy D, Nichols, Charles J, Bush, Eugene N, Diaz, Gilbert, Bammert, Gary, Nguyen, A. T, Johnson, Edwin S, Knittle, Judith, Greer, Jonathan
Published in Journal of medicinal chemistry (01.03.1994)
Published in Journal of medicinal chemistry (01.03.1994)
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Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of Obesity
Souers, Andrew J, Gao, Ju, Brune, Michael, Bush, Eugene, Wodka, Dariusz, Vasudevan, Anil, Judd, Andrew S, Mulhern, Mathew, Brodjian, Sevan, Dayton, Brian, Shapiro, Robin, Hernandez, Lisa E, Marsh, Kennan C, Sham, Hing L, Collins, Christine A, Kym, Philip R
Published in Journal of medicinal chemistry (10.03.2005)
Published in Journal of medicinal chemistry (10.03.2005)
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Effects of Diet Composition on Body Fat and Hepatic Steatosis in an Animal (Peromyscus californicus) Model of the Metabolic Syndrome
Krugner-Higby, Lisa, Caldwell, Stephen, Coyle, Kathryn, Bush, Eugene, Atkinson, Richard, Joers, Valerie
Published in Comparative medicine (01.02.2011)
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Published in Comparative medicine (01.02.2011)
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Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics
Haviv, Fortuna, Fitzpatrick, Timothy D, Nichols, Charles J, Swenson, Rolf E, Bush, Eugene N, Diaz, Gilbert, Nguyen, A, Nellans, Hugh N, Hoffman, Daniel J
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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