Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL
Tam, Constantine S., Trotman, Judith, Opat, Stephen, Burger, Jan A., Cull, Gavin, Gottlieb, David, Harrup, Rosemary, Johnston, Patrick B., Marlton, Paula, Munoz, Javier, Seymour, John F., Simpson, David, Tedeschi, Alessandra, Elstrom, Rebecca, Yu, Yiling, Tang, Zhiyu, Han, Lynn, Huang, Jane, Novotny, William, Wang, Lai, Roberts, Andrew W.
Published in Blood (12.09.2019)
Published in Blood (12.09.2019)
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Journal Article
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
Burger, Jan A., Ghia, Paolo, Rosenwald, Andreas, Caligaris-Cappio, Federico
Published in Blood (15.10.2009)
Published in Blood (15.10.2009)
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Journal Article
Single-agent ibrutinib in treatment-naïve and relapsed/refractory chronic lymphocytic leukemia: a 5-year experience
O'Brien, Susan, Furman, Richard R., Coutre, Steven, Flinn, Ian W., Burger, Jan A., Blum, Kristie, Sharman, Jeff, Wierda, William, Jones, Jeffrey, Zhao, Weiqiang, Heerema, Nyla A., Johnson, Amy J., Luan, Ying, James, Danelle F., Chu, Alvina D., Byrd, John C.
Published in Blood (26.04.2018)
Published in Blood (26.04.2018)
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Journal Article
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
Ponader, Sabine, Chen, Shih-Shih, Buggy, Joseph J., Balakrishnan, Kumudha, Gandhi, Varsha, Wierda, William G., Keating, Michael J., O'Brien, Susan, Chiorazzi, Nicholas, Burger, Jan A.
Published in Blood (02.02.2012)
Published in Blood (02.02.2012)
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Journal Article
Long-term follow-up of the RESONATE phase 3 trial of ibrutinib vs ofatumumab
Byrd, John C., Hillmen, Peter, O'Brien, Susan, Barrientos, Jacqueline C., Reddy, Nishitha M., Coutre, Steven, Tam, Constantine S., Mulligan, Stephen P., Jaeger, Ulrich, Barr, Paul M., Furman, Richard R., Kipps, Thomas J., Thornton, Patrick, Moreno, Carol, Montillo, Marco, Pagel, John M., Burger, Jan A., Woyach, Jennifer A., Dai, Sandra, Vezan, Remus, James, Danelle F., Brown, Jennifer R.
Published in Blood (09.05.2019)
Published in Blood (09.05.2019)
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Journal Article
Secondary mutations as mediators of resistance to targeted therapy in leukemia
Daver, Naval, Cortes, Jorge, Ravandi, Farhad, Patel, Keyur P., Burger, Jan A., Konopleva, Marina, Kantarjian, Hagop
Published in Blood (21.05.2015)
Published in Blood (21.05.2015)
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Journal Article
Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)
Komarova, Natalia L., Burger, Jan A., Wodarz, Dominik
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
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Journal Article
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
Burger, Jan A., Landau, Dan A., Taylor-Weiner, Amaro, Bozic, Ivana, Zhang, Huidan, Sarosiek, Kristopher, Wang, Lili, Stewart, Chip, Fan, Jean, Hoellenriegel, Julia, Sivina, Mariela, Dubuc, Adrian M., Fraser, Cameron, Han, Yulong, Li, Shuqiang, Livak, Kenneth J., Zou, Lihua, Wan, Youzhong, Konoplev, Sergej, Sougnez, Carrie, Brown, Jennifer R., Abruzzo, Lynne V., Carter, Scott L., Keating, Michael J., Davids, Matthew S., Wierda, William G., Cibulskis, Kristian, Zenz, Thorsten, Werner, Lillian, Cin, Paola Dal, Kharchencko, Peter, Neuberg, Donna, Kantarjian, Hagop, Lander, Eric, Gabriel, Stacey, O’Brien, Susan, Letai, Anthony, Weitz, David A., Nowak, Martin A., Getz, Gad, Wu, Catherine J.
Published in Nature communications (20.05.2016)
Published in Nature communications (20.05.2016)
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Journal Article
The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
Hoellenriegel, Julia, Meadows, Sarah A., Sivina, Mariela, Wierda, William G., Kantarjian, Hagop, Keating, Michael J., Giese, Neill, O'Brien, Susan, Yu, Albert, Miller, Langdon L., Lannutti, Brian J., Burger, Jan A.
Published in Blood (29.09.2011)
Published in Blood (29.09.2011)
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Journal Article
Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials
Brown, Jennifer R, Moslehi, Javid, O'Brien, Susan, Ghia, Paolo, Hillmen, Peter, Cymbalista, Florence, Shanafelt, Tait D, Fraser, Graeme, Rule, Simon, Kipps, Thomas J, Coutre, Steven, Dilhuydy, Marie-Sarah, Cramer, Paula, Tedeschi, Alessandra, Jaeger, Ulrich, Dreyling, Martin, Byrd, John C, Howes, Angela, Todd, Michael, Vermeulen, Jessica, James, Danelle F, Clow, Fong, Styles, Lori, Valentino, Rudy, Wildgust, Mark, Mahler, Michelle, Burger, Jan A
Published in Haematologica (Roma) (01.10.2017)
Published in Haematologica (Roma) (01.10.2017)
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Journal Article
Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study
Burger, Jan A, Dr, Keating, Michael J, Prof, Wierda, William G, Prof, Hartmann, Elena, MD, Hoellenriegel, Julia, MS, Rosin, Nathalie Y, PhD, de Weerdt, Iris, MD, Jeyakumar, Ghayathri, MD, Ferrajoli, Alessandra, MD, Cardenas-Turanzas, Marylou, PhD, Lerner, Susan, MS, Jorgensen, Jeffrey L, MD, Nogueras-González, Graciela M, MS, Zacharian, Gracy, MS, Huang, Xuelin, PhD, Kantarjian, Hagop, Prof, Garg, Naveen, MD, Rosenwald, Andreas, Prof, O'Brien, Susan, Prof
Published in The lancet oncology (01.09.2014)
Published in The lancet oncology (01.09.2014)
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Journal Article
Sustained efficacy and detailed clinical follow-up of first-line ibrutinib treatment in older patients with chronic lymphocytic leukemia: extended phase 3 results from RESONATE-2
Barr, Paul M, Robak, Tadeusz, Owen, Carolyn, Tedeschi, Alessandra, Bairey, Osnat, Bartlett, Nancy L, Burger, Jan A, Hillmen, Peter, Coutre, Steven, Devereux, Stephen, Grosicki, Sebastian, McCarthy, Helen, Li, Jianyong, Simpson, David, Offner, Fritz, Moreno, Carol, Zhou, Cathy, Styles, Lori, James, Danelle, Kipps, Thomas J, Ghia, Paolo
Published in Haematologica (Roma) (01.09.2018)
Published in Haematologica (Roma) (01.09.2018)
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Journal Article
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
Landau, Dan A., Sun, Clare, Rosebrock, Daniel, Herman, Sarah E. M., Fein, Joshua, Sivina, Mariela, Underbayev, Chingiz, Liu, Delong, Hoellenriegel, Julia, Ravichandran, Sarangan, Farooqui, Mohammed Z. H., Zhang, Wandi, Cibulskis, Carrie, Zviran, Asaf, Neuberg, Donna S., Livitz, Dimitri, Bozic, Ivana, Leshchiner, Ignaty, Getz, Gad, Burger, Jan A., Wiestner, Adrian, Wu, Catherine J.
Published in Nature communications (19.12.2017)
Published in Nature communications (19.12.2017)
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Journal Article