Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists
Zhang, Yingnan, Ultsch, Mark, Skelton, Nicholas J, Burdick, Daniel J, Beresini, Maureen H, Li, Wei, Kong-Beltran, Monica, Peterson, Andrew, Quinn, John, Chiu, Cecilia, Wu, Yan, Shia, Steven, Moran, Paul, Di Lello, Paola, Eigenbrot, Charles, Kirchhofer, Daniel
Published in Nature structural & molecular biology (01.10.2017)
Published in Nature structural & molecular biology (01.10.2017)
Get full text
Journal Article
Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Estrada, Anthony A, Liu, Xingrong, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chan, Bryan K, Chen, Huifen, Ding, Xiao, DiPasquale, Antonio G, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Flynn, Sean, Fuji, Reina, Gill, Andrew, Gunzner-Toste, Janet, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Le Pichon, Claire E, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Mukund, Susmith, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Tran, Thuy, Trivedi, Naimisha, Wang, Shumei, Zhang, Shuo, Zhang, Xiaolin, Zhao, Guiling, Zhu, Haitao, Sweeney, Zachary K
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
Get full text
Journal Article
Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors
Burdick, Daniel J., Wang, Shumei, Heise, Christopher, Pan, Borlan, Drummond, Jake, Yin, JianPing, Goeser, Lauren, Magnuson, Steven, Blaney, Jeff, Moffat, John, Wang, Weiru, Chen, Huifen
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Get full text
Journal Article
Diagnostic Validation for Participants in the Washington State Parkinson Disease Registry
Zabetian, Cyrus P., Samii, Ali, Millard, Steven P., Hu, Shu-Ching, Pate, Jennifer, Srivatsal, Sindhu, Burdick, Daniel J., Leverenz, James B., Kim, Hojoong M., Davis, Marie Y.
Published in Parkinson's disease (01.01.2018)
Published in Parkinson's disease (01.01.2018)
Get full text
Journal Article
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Sheng, Zejuan, Zhang, Shuo, Bustos, Daisy, Kleinheinz, Tracy, Le Pichon, Claire E, Dominguez, Sara L, Solanoy, Hilda O, Drummond, Jason, Zhang, Xiaolin, Ding, Xiao, Cai, Fang, Song, Qinghua, Li, Xianting, Yue, Zhenyu, van der Brug, Marcel P, Burdick, Daniel J, Gunzner-Toste, Janet, Chen, Huifen, Liu, Xingrong, Estrada, Anthony A, Sweeney, Zachary K, Scearce-Levie, Kimberly, Moffat, John G, Kirkpatrick, Donald S, Zhu, Haitao
Published in Science translational medicine (12.12.2012)
Published in Science translational medicine (12.12.2012)
Get more information
Journal Article
A Randomized Phase 3 Study Comparing P2B001 to its Components (Low‐Dose Extended‐Release Rasagiline and Pramipexole) and to Optimized Doses of Marketed Extended‐Release Pramipexole in Early Parkinson's Disease
Olanow, C. Warren, Hauser, Robert A., Burdick, Daniel J., Dhall, Rohit, Marcaida, Joy Antonelle, Gil, Ramon A., Kreitzman, David L., Elmer, Lawrence W., McGarry, Andrew, Kieburtz, Karl
Published in Movement disorders (01.02.2024)
Published in Movement disorders (01.02.2024)
Get full text
Journal Article
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains
Crawford, Terry D, Tsui, Vickie, Flynn, E. Megan, Wang, Shumei, Taylor, Alexander M, Côté, Alexandre, Audia, James E, Beresini, Maureen H, Burdick, Daniel J, Cummings, Richard, Dakin, Les A, Duplessis, Martin, Good, Andrew C, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Kiefer, James R, Jiang, Ying, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands
Steffek, Micah, Helgason, Elizabeth, Popovych, Nataliya, Rougé, Lionel, Bruning, John M., Li, Ke Sherry, Burdick, Daniel J., Cai, Jianping, Crawford, Terry, Xue, Jing, Decurtins, Willy, Fang, Chunlin, Grubers, Felix, Holliday, Michael J., Langley, Allyson, Petersen, Ann, Satz, Alexander Lee, Song, Aimin, Stoffler, Daniel, Strebel, Quentin, Tom, Jeffrey Y. K., Skelton, Nicholas, Staben, Steven T., Wichert, Moreno, Mulvihill, Melinda M., Dueber, Erin C.
Published in Biochemistry (Easton) (07.02.2023)
Published in Biochemistry (Easton) (07.02.2023)
Get full text
Journal Article
Design of Organo-Peptides As Bipartite PCSK9 Antagonists
Burdick, Daniel J, Skelton, Nicholas J, Ultsch, Mark, Beresini, Maureen H, Eigenbrot, Charles, Li, Wei, Zhang, Yingnan, Nguyen, Huy, Kong-Beltran, Monica, Quinn, John G, Kirchhofer, Daniel
Published in ACS chemical biology (21.02.2020)
Published in ACS chemical biology (21.02.2020)
Get full text
Journal Article
Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
Estrada, Anthony A, Chan, Bryan K, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J, Chambers, Mark, Chen, Huifen, Dominguez, Sara L, Dotson, Jennafer, Drummond, Jason, Flagella, Michael, Fuji, Reina, Gill, Andrew, Halladay, Jason, Harris, Seth F, Heffron, Timothy P, Kleinheinz, Tracy, Lee, Donna W, Pichon, Claire E. Le, Liu, Xingrong, Lyssikatos, Joseph P, Medhurst, Andrew D, Moffat, John G, Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G, Wong, Susan, Zhang, Shuo, Zhang, Xiaolin, Zhu, Haitao, Sweeney, Zachary K
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
Get full text
Journal Article
Optimization of globomycin analogs as novel gram-negative antibiotics
Garland, Keira, Pantua, Homer, Braun, Marie-Gabrielle, Burdick, Daniel J., Castanedo, Georgette M., Chen, Yi-Chen, Cheng, Yun-Xing, Cheong, Jonathan, Daniels, Blake, Deshmukh, Gauri, Fu, Yuhong, Gibbons, Paul, Gloor, Susan L., Hua, Rongbao, Labadie, Sharada, Liu, Xiongcai, Pastor, Richard, Stivala, Craig, Xu, Min, Xu, Yiming, Zheng, Hao, Kapadia, Sharookh B., Hanan, Emily J.
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Published in Bioorganic & medicinal chemistry letters (15.10.2020)
Get full text
Journal Article
Leading with inclusion during the COVID-19 pandemic: Stronger together
Warrior, Lakshmi, Kim, Christine Y, Burdick, Daniel J, Ackerman, Daniel J, Bartolini, Luca, Cagniart, Kendra R, Dangayach, Neha S, Dawson, Elliot T, Orjuela, Karen D, Gordon Perue, Gillian L, Cutsforth-Gregory, Jeremy K, Bahouth, Mona N, McClean, 2nd, Jeffrey C, DeLuca, Gabriele C
Published in Neurology (22.09.2020)
Published in Neurology (22.09.2020)
Get more information
Journal Article
A case of tremor in Klinefelter syndrome worsened by testosterone administration
Burdick, Daniel J, Griffith, Alida, Agarwal, Pinky
Published in Parkinsonism & related disorders (01.04.2015)
Published in Parkinsonism & related disorders (01.04.2015)
Get full text
Journal Article
Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling
Chen, Huifen, Chan, Bryan K, Drummond, Jason, Estrada, Anthony A, Gunzner-Toste, Janet, Liu, Xingrong, Liu, Yichin, Moffat, John, Shore, Daniel, Sweeney, Zachary K, Tran, Thuy, Wang, Shumei, Zhao, Guiling, Zhu, Haitao, Burdick, Daniel J
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
Get full text
Journal Article
People with Parkinson's disease and normal MMSE score have a broad range of cognitive performance
Burdick, Daniel J., Cholerton, Brenna, Watson, G.S., Siderowf, Andrew, Trojanowski, John Q., Weintraub, Daniel, Ritz, Beate, Rhodes, Shannon L., Rausch, Renecca, Factor, Stewart A., Wood-Siverio, Cathy, Quinn, Joseph F., Chung, Kathryn A., Srivatsal, Sindhu, Edwards, Karen L., Montine, Thomas J., Zabetian, Cyrus P., Leverenz, James B.
Published in Movement disorders (01.09.2014)
Published in Movement disorders (01.09.2014)
Get full text
Journal Article
Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
Get full text
Journal Article
GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1‑like
Wang, Shumei, Tsui, Vickie, Crawford, Terry D, Audia, James E, Burdick, Daniel J, Beresini, Maureen H, Côté, Alexandre, Cummings, Richard, Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael C, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Murray, Jeremy, Nasveschuk, Christopher G, Pardo, Eneida, Poy, Florence, Romero, F. Anthony, Tang, Yong, Taylor, Alexander M, Wang, Jian, Xu, Zhaowu, Zawadzke, Laura E, Zhu, Xiaoyu, Albrecht, Brian K, Magnuson, Steven R, Bellon, Steve, Cochran, Andrea G
Published in Journal of medicinal chemistry (25.10.2018)
Published in Journal of medicinal chemistry (25.10.2018)
Get full text
Journal Article
Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR
Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J, Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
Get full text
Journal Article