A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Hattori, Shin-Ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J, Lendy, Emma K, Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A, Kodama, Eiichi N, Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Nature communications (28.01.2021)
Published in Nature communications (28.01.2021)
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Disruption of endocytosis through chemical inhibition of clathrin heavy chain function
Dejonghe, Wim, Sharma, Isha, Denoo, Bram, De Munck, Steven, Lu, Qing, Mishev, Kiril, Bulut, Haydar, Mylle, Evelien, De Rycke, Riet, Vasileva, Mina, Savatin, Daniel V, Nerinckx, Wim, Staes, An, Drozdzecki, Andrzej, Audenaert, Dominique, Yperman, Klaas, Madder, Annemieke, Friml, Jiří, Van Damme, Daniël, Gevaert, Kris, Haucke, Volker, Savvides, Savvas N, Winne, Johan, Russinova, Eugenia
Published in Nature chemical biology (01.06.2019)
Published in Nature chemical biology (01.06.2019)
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Journal Article
Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
von Kleist, Lisa, Stahlschmidt, Wiebke, Bulut, Haydar, Gromova, Kira, Puchkov, Dmytro, Robertson, Mark J., MacGregor, Kylie A., Tomlin, Nikolay, Pechstein, Arndt, Chau, Ngoc, Chircop, Megan, Sakoff, Jennette, von Kries, Jens Peter, Saenger, Wolfram, Kräusslich, Hans-Georg, Shupliakov, Oleg, Robinson, Phillip J., McCluskey, Adam, Haucke, Volker
Published in Cell (05.08.2011)
Published in Cell (05.08.2011)
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Structure–Activity Relationship Studies of SARS-CoV‑2 Main Protease Inhibitors Containing 4‑Fluorobenzothiazole-2-carbonyl Moieties
Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Shinohara, Kouki, Azuma, Chika, Miura, Yutaro, Nakano, Hiroki, Wada, Naoya, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Journal Article
GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection
Hattori, Shin-Ichiro, Higshi-Kuwata, Nobuyo, Raghavaiah, Jakka, Das, Debananda, Bulut, Haydar, Davis, David A, Takamatsu, Yuki, Matsuda, Kouki, Takamune, Nobutoki, Kishimoto, Naoki, Okamura, Tadashi, Misumi, Shogo, Yarchoan, Robert, Maeda, Kenji, Ghosh, Arun K, Mitsuya, Hiroaki
Published in mBio (20.08.2020)
Published in mBio (20.08.2020)
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Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
Bulut, Haydar, Hattori, Shin-Ichiro, Aoki-Ogata, Hiromi, Hayashi, Hironori, Das, Debananda, Aoki, Manabu, Davis, David A, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Ghosh, Arun K, Mitsuya, Hiroaki
Published in Scientific reports (30.06.2020)
Published in Scientific reports (30.06.2020)
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Journal Article
Identification of a novel long-acting 4’-modified nucleoside reverse transcriptase inhibitor against HBV
Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Kumamoto, Hiroki, Ogata-Aoki, Hiromi, Das, Debananda, Venzon, David, Hattori, Shin-ichiro, Bulut, Haydar, Hashimoto, Mai, Otagiri, Masaki, Takamune, Nobutoki, Kishimoto, Naoki, Davis, David A., Misumi, Shogo, Kakuni, Masakazu, Tanaka, Yasuhito, Mitsuya, Hiroaki
Published in Journal of hepatology (01.05.2021)
Published in Journal of hepatology (01.05.2021)
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-Ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Published in eLife (17.10.2017)
Published in eLife (17.10.2017)
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Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition
Amano, Masayuki, Bulut, Haydar, Tamiya, Sadahiro, Nakamura, Tomofumi, Koh, Yasuhiro, Mitsuya, Hiroaki
Published in Scientific reports (08.07.2019)
Published in Scientific reports (08.07.2019)
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Journal Article
Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement
Tsuji, Kohei, Kobayakawa, Takuya, Ishii, Takahiro, Higashi-Kuwata, Nobuyo, Azuma, Chika, Shinohara, Kouki, Miura, Yutaro, Yamamoto, Kenichi, Nishimura, Soshi, Hattori, Shin-ichiro, Bulut, Haydar, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in Chemical & pharmaceutical bulletin (01.12.2023)
Published in Chemical & pharmaceutical bulletin (01.12.2023)
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Journal Article
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300
Davis, David A, Bulut, Haydar, Shrestha, Prabha, Yaparla, Amulya, Jaeger, Hannah K, Hattori, Shin-ichiro, Wingfield, Paul T, Mieyal, John J, Mitsuya, Hiroaki, Yarchoan, Robert
Published in mBio (31.08.2021)
Published in mBio (31.08.2021)
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Journal Article
Identification of SARS-CoV-2 Mpro inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2
Higashi-Kuwata, Nobuyo, Tsuji, Kohei, Hayashi, Hironori, Bulut, Haydar, Kiso, Maki, Imai, Masaki, Ogata-Aoki, Hiromi, Ishii, Takahiro, Kobayakawa, Takuya, Nakano, Kenta, Takamune, Nobutoki, Kishimoto, Naoki, Hattori, Shin-ichiro, Das, Debananda, Uemura, Yukari, Shimizu, Yosuke, Aoki, Manabu, Hasegawa, Kazuya, Suzuki, Satoshi, Nishiyama, Akie, Saruwatari, Junji, Shimizu, Yukiko, Sukenaga, Yoshikazu, Takamatsu, Yuki, Tsuchiya, Kiyoto, Maeda, Kenji, Yoshimura, Kazuhisa, Iida, Shun, Ozono, Seiya, Suzuki, Tadaki, Okamura, Tadashi, Misumi, Shogo, Kawaoka, Yoshihiro, Tamamura, Hirokazu, Mitsuya, Hiroaki
Published in Nature communications (25.02.2023)
Published in Nature communications (25.02.2023)
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Journal Article
Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation
Davis, David A, Bulut, Haydar, Shrestha, Prabha, Mitsuya, Hiroaki, Yarchoan, Robert
Published in Antioxidants (01.10.2022)
Published in Antioxidants (01.10.2022)
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Crystal Structures of Two Solute Receptors for l-Cystine and l-Cysteine, Respectively, of the Human Pathogen Neisseria gonorrhoeae
Bulut, Haydar, Moniot, Sebastien, Licht, Anke, Scheffel, Frank, Gathmann, Stephanie, Saenger, Wolfram, Schneider, Erwin
Published in Journal of molecular biology (20.01.2012)
Published in Journal of molecular biology (20.01.2012)
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Potent and biostable inhibitors of the main protease of SARS-CoV-2
Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Azuma, Chika, Nakayama, Miyuki, Onishi, Takato, Nakano, Hiroki, Wada, Naoya, Hori, Miki, Shinohara, Kouki, Miura, Yutaro, Kawada, Takuma, Hayashi, Hironori, Hattori, Shin-ichiro, Bulut, Haydar, Das, Debananda, Takamune, Nobutoki, Kishimoto, Naoki, Saruwatari, Junji, Okamura, Tadashi, Nakano, Kenta, Misumi, Shogo, Mitsuya, Hiroaki, Tamamura, Hirokazu
Published in iScience (18.11.2022)
Published in iScience (18.11.2022)
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Journal Article
Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2
Hattori, Shin-ichiro, Bulut, Haydar, Hayashi, Hironori, Kishimoto, Naoki, Takamune, Nobutoki, Hasegawa, Kazuya, Furusawa, Yuri, Yamayoshi, Seiya, Murayama, Kazutaka, Tamamura, Hirokazu, Li, Mi, Wlodawer, Alexander, Kawaoka, Yoshihiro, Misumi, Shogo, Mitsuya, Hiroaki
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
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Journal Article
Structural and virologic mechanism of the emergence of resistance to Mpro inhibitors in SARS-CoV-2
Hattori, Shin-Ichiro, Bulut, Haydar, Hayashi, Hironori, Kishimoto, Naoki, Takamune, Nobutoki, Hasegawa, Kazuya, Furusawa, Yuri, Yamayoshi, Seiya, Murayama, Kazutaka, Tamamura, Hirokazu, Li, Mi, Wlodawer, Alexander, Kawaoka, Yoshihiro, Misumi, Shogo, Mitsuya, Hiroaki
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2024)
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Journal Article
Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
Ghosh, Arun K, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Osswald, Heather L, Martyr, Cuthbert D, Aoki, Manabu, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Bulut, Haydar, Das, Debananda, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Journal Article
Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing
Jung, SangYong, Maritzen, Tanja, Wichmann, Carolin, Jing, Zhizi, Neef, Andreas, Revelo, Natalia H, Al-Moyed, Hanan, Meese, Sandra, Wojcik, Sonja M, Panou, Iliana, Bulut, Haydar, Schu, Peter, Ficner, Ralf, Reisinger, Ellen, Rizzoli, Silvio O, Neef, Jakob, Strenzke, Nicola, Haucke, Volker, Moser, Tobias
Published in The EMBO journal (03.11.2015)
Published in The EMBO journal (03.11.2015)
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