Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP‐5862, in patients with B‐cell malignancies and in healthy subjects using a population pharmacokinetic approach
Edlund, Helena, Bellanti, Francesco, Liu, Huan, Vishwanathan, Karthick, Tomkinson, Helen, Ware, Joseph, Sharma, Shringi, Buil‐Bruna, Núria
Published in British journal of clinical pharmacology (01.02.2022)
Published in British journal of clinical pharmacology (01.02.2022)
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Exposure–response analysis of acalabrutinib and its active metabolite, ACP‐5862, in patients with B‐cell malignancies
Edlund, Helena, Buil‐Bruna, Núria, Vishwanathan, Karthick, Wei, Helen, Raman, Rakesh, Kock, Miné, He, Zhongqing, Liu, Huan, Baek, Marshall, Ware, Joseph, Patel, Priti, Tomkinson, Helen, Sharma, Shringi
Published in British journal of clinical pharmacology (01.05.2022)
Published in British journal of clinical pharmacology (01.05.2022)
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Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules
Mangas-Sanjuan, Víctor, Buil-Bruna, Núria, Garrido, María J, Soto, Elena, Trocóniz, Iñaki F
Published in The Journal of pharmacology and experimental therapeutics (01.07.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2015)
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Population Pharmacokinetic Analysis of Lanreotide Autogel®/Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials
Buil-Bruna, Núria, Garrido, María Jesús, Dehez, Marion, Manon, Amandine, Nguyen, Thi Xuan Quyen, Gomez-Panzani, Edda L., Trocóniz, Iñaki F.
Published in Clinical pharmacokinetics (01.04.2016)
Published in Clinical pharmacokinetics (01.04.2016)
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A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients
Buil-Bruna, Núria, López-Picazo, José-María, Moreno-Jiménez, Marta, Martín-Algarra, Salvador, Ribba, Benjamin, Trocóniz, Iñaki F.
Published in The AAPS journal (01.05.2014)
Published in The AAPS journal (01.05.2014)
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Early Prediction of Disease Progression in Small Cell Lung Cancer: Toward Model-Based Personalized Medicine in Oncology
Buil-Bruna, Núria, Sahota, Tarjinder, López-Picazo, José-María, Moreno-Jiménez, Marta, Martín-Algarra, Salvador, Ribba, Benjamin, Trocóniz, Iñaki F
Published in Cancer research (Chicago, Ill.) (15.06.2015)
Published in Cancer research (Chicago, Ill.) (15.06.2015)
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Establishing the Quantitative Relationship Between Lanreotide Autogel®, Chromogranin A, and Progression-Free Survival in Patients with Nonfunctioning Gastroenteropancreatic Neuroendocrine Tumors
Buil-Bruna, Núria, Dehez, Marion, Manon, Amandine, Nguyen, Thi Xuan Quyen, Trocóniz, Iñaki F.
Published in The AAPS journal (01.05.2016)
Published in The AAPS journal (01.05.2016)
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Abstract A094: Phase I modular study of AZD0156, a first-in-class oral selective inhibitor of ataxia telangiectasia mutated protein kinase (ATM), in combination with olaparib (AToM Study, Module 1)
Abida, Wassim, Bang, Yung J., Carter, Louise, Azaro, Analía, Krebs, Matthew, Im, Seock-Ah, Chen, Yingxue, Buil-Bruna, Núria, Li, Yan, Eaton, David, Stephens, Christine, Ross, Graham, Pass, Martin, Rodon, Jordi, Dean, Emma
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Population Pharmacokinetic Analysis of Lanreotide Autogel^sup ®^/ Depot in the Treatment of Neuroendocrine Tumors: Pooled Analysis of Four Clinical Trials
Buil-Bruna, Núria, Garrido, María Jesús, Dehez, Marion, Manon, Amandine, Nguyen, Thi Xuan Quyen, Gomez-Panzani, Edda L, Trocóniz, Iñaki F
Published in Clinical pharmacokinetics (01.04.2016)
Published in Clinical pharmacokinetics (01.04.2016)
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Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study
Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.04.2021)
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Abstract 4868: A preclinical PK/PD model based on a mouse glioblastoma survival model for AZD1390, a novel, brain-penetrant ATM kinase inhibitor, to predict the inhibition of DNA damage response induced by radiation and the human efficacious dose
Reddy, Venkatesh Pilla, Sykes, Andy, Colclough, Nicola, Durant, Stephen T., O'Connor, Lenka Oplustil, Hoch, Matthias, Bruna, Nuria Buil, Vita, Serena De, Merchant, Melinda, Pass, Martin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Population pharmacokinetic (PK) analysis of lanreotide autogel/depot in the treatment of gastroenteropancreatic (GEP) neuroendocrine tumors (NETs): Pooled analysis of four clinical trials
Buil-Bruna, Nuria, Garrido, Maria Jesus, Dehez, Marion, Manon, Amandine, Nguyen, Thi Xuan Quyen, Gomez-Panzani, Edda L., Troconiz, Inaki F
Published in Journal of clinical oncology (20.01.2015)
Published in Journal of clinical oncology (20.01.2015)
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