Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
Huber, Andrew D., Wright, William C., Lin, Wenwei, Majumder, Kinjal, Low, Jonathan A., Wu, Jing, Buchman, Cameron D., Pintel, David J., Chen, Taosheng
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
Published in Cellular and molecular life sciences : CMLS (01.01.2021)
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Journal Article
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy
Huddle, Brandt C, Grimley, Edward, Buchman, Cameron D, Chtcherbinine, Mikhail, Debnath, Bikash, Mehta, Pooja, Yang, Kun, Morgan, Cynthia A, Li, Siwei, Felton, Jeremy, Sun, Duxin, Mehta, Geeta, Neamati, Nouri, Buckanovich, Ronald J, Hurley, Thomas D, Larsen, Scott D
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Journal Article
A current structural perspective on PXR and CAR in drug metabolism
Buchman, Cameron D, Chai, Sergio C, Chen, Taosheng
Published in Expert opinion on drug metabolism & toxicology (01.06.2018)
Published in Expert opinion on drug metabolism & toxicology (01.06.2018)
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Journal Article
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
Bwayi, Monicah N, Garcia-Maldonado, Efren, Chai, Sergio C, Xie, Boer, Chodankar, Shirish, Huber, Andrew D, Wu, Jing, Annu, Kavya, Wright, William C, Lee, Hyeong-Min, Seetharaman, Jayaraman, Wang, Jingheng, Buchman, Cameron D, Peng, Junmin, Chen, Taosheng
Published in Nucleic acids research (08.04.2022)
Published in Nucleic acids research (08.04.2022)
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Journal Article
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5
Wang, Jingheng, Buchman, Cameron D, Seetharaman, Jayaraman, Miller, Darcie J, Huber, Andrew D, Wu, Jing, Chai, Sergio C, Garcia-Maldonado, Efren, Wright, William C, Chenge, Jude, Chen, Taosheng
Published in Journal of the American Chemical Society (10.11.2021)
Published in Journal of the American Chemical Society (10.11.2021)
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Journal Article
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy
Huddle, Brandt C., Grimley, Edward, Chtcherbinine, Mikhail, Buchman, Cameron D., Takahashi, Cyrus, Debnath, Bikash, McGonigal, Stacy C., Mao, Shuai, Li, Siwei, Felton, Jeremy, Pan, Shu, Wen, Bo, Sun, Duxin, Neamati, Nouri, Buckanovich, Ronald J., Hurley, Thomas D., Larsen, Scott D.
Published in European journal of medicinal chemistry (05.02.2021)
Published in European journal of medicinal chemistry (05.02.2021)
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Journal Article
Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors
Buchman, Cameron D., Mahalingan, Krishna K., Hurley, Thomas D.
Published in Chemico-biological interactions (05.06.2015)
Published in Chemico-biological interactions (05.06.2015)
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Journal Article
Unraveling the structural basis of selective inhibition of human cytochrome p450 3a5
Wang, Jingheng, Buchman, Cameron D., Seetharaman, Jayaraman, Miller, Darcie J., Huber, Andrew D., Wu, Jing, Chai, Sergio C., Garcia-Maldonado, Efren, Wright, William C., Chenge, Jude, Chen, Taosheng
Published in Biophysical journal (11.02.2022)
Published in Biophysical journal (11.02.2022)
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Journal Article
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A
Huddle, Brandt C., Grimley, Edward, Chtcherbinine, Mikhail, Buchman, Cameron D., Takahashi, Cyrus, Debnath, Bikash, McGonigal, Stacy C., Mao, Shuai, Li, Siwei, Felton, Jeremy, Pan, Shu, Wen, Bo, Sun, Duxin, Neamati, Nouri, Buckanovich, Ronald J., Hurley, Thomas D., Larsen, Scott D.
Published in European journal of medicinal chemistry (01.02.2021)
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Published in European journal of medicinal chemistry (01.02.2021)
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