Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J, Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D, Craik, Charles S, Konvalinka, Jan
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
QM/MM Calculations Reveal the Different Nature of the Interaction of Two Carborane-Based Sulfamide Inhibitors of Human Carbonic Anhydrase II
Pecina, Adam, Lepšík, Martin, Řezáč, Jan, Brynda, Jiří, Mader, Pavel, Řezáčová, Pavlína, Hobza, Pavel, Fanfrlík, Jindřich
Published in The journal of physical chemistry. B (19.12.2013)
Published in The journal of physical chemistry. B (19.12.2013)
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The Influence of SO2 and HCl Concentrations on the Consumption of Sodium Bicarbonate during Flue Gas Treatment
Zach, Boleslav, Šyc, Michal, Svoboda, Karel, Pohořelý, Michael, Šomplák, Radovan, Brynda, Jiří, Moško, Jaroslav, Punčochář, Miroslav
Published in Energy & fuels (18.03.2021)
Published in Energy & fuels (18.03.2021)
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Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7‑Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
Vavřina, Zdeněk, Perlíková, Pavla, Milisavljević, Nemanja, Chevrier, Florian, Smola, Miroslav, Smith, Joshua, Dejmek, Milan, Havlíček, Vojtěch, Buděšínský, Miloš, Liboska, Radek, Vaneková, Lenka, Brynda, Jiří, Boura, Evzen, Řezáčová, Pavlína, Hocek, Michal, Birkuš, Gabriel
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Enzymatic Preparation of 2′–5′,3′–5′-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Novotná, Barbora, Vaneková, Lenka, Zavřel, Martin, Buděšínský, Miloš, Dejmek, Milan, Smola, Miroslav, Gutten, Ondrej, Tehrani, Zahra Aliakbar, Pimková Polidarová, Markéta, Brázdová, Andrea, Liboska, Radek, Štěpánek, Ivan, Vavřina, Zdeněk, Jandušík, Tomáš, Nencka, Radim, Rulíšek, Lubomír, Bouřa, Evžen, Brynda, Jiří, Páv, Ondřej, Birkuš, Gabriel
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
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Journal Article
Carborane-Based Carbonic Anhydrase Inhibitors
Brynda, Jiří, Mader, Pavel, Šícha, Václav, Fábry, Milan, Poncová, Kristýna, Bakardiev, Mario, Grüner, Bohumír, Cígler, Petr, Řezáčová, Pavlína
Published in Angewandte Chemie (International ed.) (16.12.2013)
Published in Angewandte Chemie (International ed.) (16.12.2013)
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Journal Article
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure–Activity Relationship and Binding Mode Analysis
Houštecká, Radka, Hadzima, Martin, Fanfrlík, Jindřich, Brynda, Jiří, Pallová, Lenka, Hánová, Iva, Mertlíková-Kaiserová, Helena, Lepšík, Martin, Horn, Martin, Smrčina, Martin, Majer, Pavel, Mareš, Michael
Published in Journal of medicinal chemistry (27.02.2020)
Published in Journal of medicinal chemistry (27.02.2020)
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Journal Article
Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase
Gregor, Jiří, Radilová, Kateřina, Brynda, Jiří, Fanfrlík, Jindřich, Konvalinka, Jan, Kožíšek, Milan
Published in Molecules (Basel, Switzerland) (14.02.2021)
Published in Molecules (Basel, Switzerland) (14.02.2021)
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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors
Zima, Václav, Radilová, Kateřina, Kožíšek, Milan, Albiñana, Carlos Berenguer, Karlukova, Elena, Brynda, Jiří, Fanfrlík, Jindřich, Flieger, Miroslav, Hodek, Jan, Weber, Jan, Majer, Pavel, Konvalinka, Jan, Machara, Aleš
Published in European journal of medicinal chemistry (15.12.2020)
Published in European journal of medicinal chemistry (15.12.2020)
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Journal Article
Wood chips gasification in a fixed-bed multi-stage gasifier for decentralized high-efficiency CHP and biochar production: Long-term commercial operation
Brynda, Jiří, Skoblia, Siarhei, Pohořelý, Michael, Beňo, Zdeněk, Soukup, Karel, Jeremiáš, Michal, Moško, Jaroslav, Zach, Boleslav, Trakal, Lukáš, Šyc, Michal, Svoboda, Karel
Published in Fuel (Guildford) (01.12.2020)
Published in Fuel (Guildford) (01.12.2020)
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Journal Article
Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions
Dziuba, Dmytro, Pospisil, Petr, Matyasovsky, Jan, Brynda, Jiri, Nachtigallova, Dana, Rulisek, Lubomir, Pohl, Radek, Hof, Martin, Hocek, Michal
Published in Chemical science (Cambridge) (01.01.2016)
Published in Chemical science (Cambridge) (01.01.2016)
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Journal Article
Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds
Kugler, Michael, Nekvinda, Jan, Holub, Josef, El Anwar, Suzan, Das, Viswanath, Šícha, Václav, Pospíšilová, Klára, Fábry, Milan, Král, Vlastimil, Brynda, Jiří, Kašička, Václav, Hajdúch, Marián, Řezáčová, Pavlína, Grüner, Bohumír
Published in Chembiochem : a European journal of chemical biology (14.09.2021)
Published in Chembiochem : a European journal of chemical biology (14.09.2021)
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Journal Article
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog
Sivá, Monika, Svoboda, Michal, Veverka, Václav, Trempe, Jean-François, Hofmann, Kay, Kožíšek, Milan, Hexnerová, Rozálie, Sedlák, František, Belza, Jan, Brynda, Jiří, Šácha, Pavel, Hubálek, Martin, Starková, Jana, Flaisigová, Iva, Konvalinka, Jan, Šašková, Klára Grantz
Published in Scientific reports (27.07.2016)
Published in Scientific reports (27.07.2016)
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Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family
Šoltysová, Markéta, Sieglová, Irena, Fábry, Milan, Brynda, Jiří, Škerlová, Jana, Řezáčová, Pavlína
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2021)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2021)
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Determination of acidity constants, ionic mobilities, and hydrodynamic radii of carborane‐based inhibitors of carbonic anhydrases by capillary electrophoresis
Šolínová, Veronika, Brynda, Jiří, Šícha, Václav, Holub, Josef, Grűner, Bohumír, Kašička, Václav
Published in Electrophoresis (01.04.2021)
Published in Electrophoresis (01.04.2021)
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Journal Article
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
Published in Journal of enzyme inhibition and medicinal chemistry (01.12.2022)
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Journal Article
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Skácel, Jan, Djukic, Stefan, Baszczyňski, Ondřej, Kalčic, Filip, Bílek, Tadeáš, Chalupský, Karel, Kozák, Jaroslav, Dvořáková, Alexandra, Tloušt’ová, Eva, Král’ová, Zuzana, Šmídková, Markéta, Voldřich, Jan, Rumlová, Michaela, Pachl, Petr, Brynda, Jiří, Vučková, Tereza, Fábry, Milan, Snášel, Jan, Pichová, Iva, Řezáčová, Pavlína, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (25.05.2023)
Published in Journal of medicinal chemistry (25.05.2023)
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Journal Article
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors
Reiberger, Robert, Radilová, Kateřina, Kráľ, Michal, Zima, Václav, Majer, Pavel, Brynda, Jiří, Dračínský, Martin, Konvalinka, Jan, Kožíšek, Milan, Machara, Aleš
Published in International journal of molecular sciences (20.07.2021)
Published in International journal of molecular sciences (20.07.2021)
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Journal Article
From Nonpeptide toward Noncarbon Protease Inhibitors: Metallacarboranes as Specific and Potent Inhibitors of HIV Protease
Petr Cígler, Milan Kožíšek, Pavlína Řezáčová, Jíří Brynda, Otwinowski, Zbyszek, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Lucie Dolečková-Marešová, Martin Máša, Juraj Sedláček, Jochen Bodem, Kräusslich, Hans-Georg, Král, Vladimír, Jan Konvalinka
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2005)
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