Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism
Silverman, Jill L, Smith, Daniel G, Rizzo, Stacey J Sukoff, Karras, Michael N, Turner, Sarah M, Tolu, Seda S, Bryce, Dianne K, Smith, Deborah L, Fonseca, Kari, Ring, Robert H, Crawley, Jacqueline N
Published in Science translational medicine (25.04.2012)
Published in Science translational medicine (25.04.2012)
Get more information
Journal Article
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity
Bryce, Dianne K, Ware, Chris M, Woodhouse, Janice D, Ciaccio, Paul J, Ellis, J Michael, Hegde, Laxminarayan G, Kuruvilla, Sabu, Maddess, Matthew L, Markgraf, Carrie G, Otte, Karin M, Poulet, Frederique M, Timmins, Lauren M, Kennedy, Matthew E, Fell, Matthew J
Published in The Journal of pharmacology and experimental therapeutics (01.04.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2021)
Get full text
Journal Article
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574
Shaffer, Christopher L, Hurst, Raymond S, Scialis, Renato J, Osgood, Sarah M, Bryce, Dianne K, Hoffmann, William E, Lazzaro, John T, Hanks, Ashley N, Lotarski, Susan, Weber, Mark L, Liu, JianHua, Menniti, Frank S, Schmidt, Christopher J, Hajós, Mihály
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Get full text
Journal Article
The Discovery and Characterization of the α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N‑{(3S,4S)‑4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Shaffer, Christopher L, Patel, Nandini C, Schwarz, Jacob, Scialis, Renato J, Wei, Yunjing, Hou, Xinjun J, Xie, Longfei, Karki, Kapil, Bryce, Dianne K, Osgood, Sarah M, Hoffmann, William E, Lazzaro, John T, Chang, Cheng, McGinnis, Dina F, Lotarski, Susan M, Liu, JianHua, Obach, R. Scott, Weber, Mark L, Chen, Laigao, Zasadny, Kenneth R, Seymour, Patricia A, Schmidt, Christopher J, Hajós, Mihály, Hurst, Raymond S, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
Get full text
Journal Article
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits
Baptista, Marco A S, Merchant, Kalpana, Barrett, Ted, Bhargava, Sakshi, Bryce, Dianne K, Ellis, J Michael, Estrada, Anthony A, Fell, Matthew J, Fiske, Brian K, Fuji, Reina N, Galatsis, Paul, Henry, Anastasia G, Hill, Sue, Hirst, Warren, Houle, Christopher, Kennedy, Matthew E, Liu, Xingrong, Maddess, Matthew L, Markgraf, Carrie, Mei, Hong, Meier, William A, Needle, Elie, Ploch, Stephen, Royer, Christopher, Rudolph, Karin, Sharma, Alok K, Stepan, Antonia, Steyn, Stefan, Trost, Craig, Yin, Zhizhang, Yu, Hongshi, Wang, Xiang, Sherer, Todd B
Published in Science translational medicine (22.04.2020)
Published in Science translational medicine (22.04.2020)
Get more information
Journal Article
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel alpha 7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O'Donnell, Christopher J., Rogers, Bruce N., Bronk, Brian S., Bryce, Dianne K., Coe, Jotham W., Cook, Karen K., Duplantier, Allen J., Evrard, Edelweiss, Hajos, Mihaly, Hoffmann, William E., Hurst, Raymond S., Maklad, Noha, Mather, Robert J., McLean, Stafford, Nedza, Frank M., O'Neill, Brian T., Peng, Langu, Qian, Weimin, Rottas, Melinda M., Sands, Steven B., Schmidt, Anne W., Shrikhande, Alka V., Spracklin, Douglas K., Wong, Diane F., Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
Patel, Nandini C, Schwarz, Jacob, Hou, Xinjun J, Hoover, Dennis J, Xie, Longfei, Fliri, Anton J, Gallaschun, Randall J, Lazzaro, John T, Bryce, Dianne K, Hoffmann, William E, Hanks, Ashley N, McGinnis, Dina, Marr, Eric S, Gazard, Justin L, Hajós, Mihály, Scialis, Renato J, Hurst, Raymond S, Shaffer, Christopher L, Pandit, Jayvardhan, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (27.11.2013)
Published in Journal of medicinal chemistry (27.11.2013)
Get full text
Journal Article
Biaryl piperidines as potent and selective delta opioid receptor ligands
Liras, Spiros, McHardy, Stanton F., Allen, Martin P., Segelstein, Barb E., Heck, Steven D., Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, McLean, Stafford
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Get full text
Journal Article
Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models
O’Donnell, Christopher J, Rogers, Bruce N, Bronk, Brian S, Bryce, Dianne K, Coe, Jotham W, Cook, Karen K, Duplantier, Allen J, Evrard, Edelweiss, Hajós, Mihaly, Hoffmann, William E, Hurst, Raymond S, Maklad, Noha, Mather, Robert J, McLean, Stafford, Nedza, Frank M, O’Neill, Brian T, Peng, Langu, Qian, Weimin, Rottas, Melinda M, Sands, Steven B, Schmidt, Anne W, Shrikhande, Alka V, Spracklin, Douglas K, Wong, Diane F, Zhang, Andy, Zhang, Lei
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK$_1$) Receptor Antagonist
McLean, Stafford, Ganong, Alan H., Seeger, Thomas F., Bryce, Dianne K., Pratt, Kara G., Reynolds, Linda S., Siok, Chester J., Lowe, John A., Heym, James
Published in Science (American Association for the Advancement of Science) (25.01.1991)
Published in Science (American Association for the Advancement of Science) (25.01.1991)
Get full text
Journal Article
The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist
Lowe, John A, Drozda, Susan E, Snider, R. Michael, Longo, Kelly P, Zorn, Stevin H, Morrone, Jean, Jackson, Elisa R, McLean, Stafford, Bryce, Dianne K
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
Get full text
Journal Article
Cardiovascular Effects of Cholecystokinin-4 Are Mediated By the Cholecystokinin-B Receptor Subtype In the Conscious Guinea Pig and Dog
Fossa, A A, DePasquale, M J, Morrone, J, Zorn, S H, Bryce, D, Lowe, J A, McLean, S
Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
Get full text
Published in The Journal of pharmacology and experimental therapeutics (01.04.1997)
Journal Article
5-Phenyl-3-ureidobenzazepin-2-ones as Cholecystokinin-B Receptor Antagonists
Lowe, John A, Hageman, David L, Drozda, Susan E, McLean, Stafford, Bryce, Dianne K, Crawford, Rosemary T, Zorn, Stevin, Morrone, Jean, Bordner, Jon
Published in Journal of medicinal chemistry (01.10.1994)
Published in Journal of medicinal chemistry (01.10.1994)
Get full text
Journal Article
Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand
Rosen, Terry, Seeger, Thomas F, McLean, Stafford, Desai, Manoj C, Guarino, Karen J, Bryce, Dianne, Pratt, Kara, Heym, James, Chalabi, Philip M
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
Get full text
Journal Article
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
Rosen, Terry J., Coffman, Karen J., McLean, Stafford, Crawford, Rosemary T., Bryce, Dianne K., Gohda, Yoshiko, Tsuchiya, Megumi, Nagahisa, Atsushi, Nakane, Masami, Lowe, John A.
Published in Bioorganic & medicinal chemistry letters (03.02.1998)
Published in Bioorganic & medicinal chemistry letters (03.02.1998)
Get full text
Journal Article
Discovery of CP-866,087, a mu opioid receptor antagonist for the treatment of alcohol abuse and dependence
McHardy, Stanton F., Heck, Steven D., Guediche, Sara, Kalman, Monica, Allen, Martin P., Tu, Meihua, Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, Doran, Shawn, Grahame, Nicholas J., McLean, Stafford, Liras, Spiros
Published in MedChemComm (01.10.2011)
Published in MedChemComm (01.10.2011)
Get full text
Journal Article
Discovery of CP-96,345 and its characterization in disease models involving substance P
Lowe, John A, Drozda, Susan E, Michael Snider, R, Longo, Kelly P, Zorn, Stevin H, Jackson, Elisa R, Morrone, Jean, McLean, Stafford, Bryce, Dianne K, Bordner, Jon, Nagahisa, Atsushi, Kanai, Yoshihito, Suga, Osamu, Tsuchiya, Megumi
Published in Regulatory peptides (02.07.1993)
Published in Regulatory peptides (02.07.1993)
Get full text
Journal Article
Conference Proceeding
The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine as a novel, nonpeptide substance P antagonist. [Erratum to document cited in CA117(5):48289n]
Lowe, John A, Drozda, Susan E, Snider, R. Michael, Longo, Kelly P, Zorn, Stevin H, Morrone, Jean, Jackson, Elisa R, McLean, Stafford, Bryce, Dianne K
Published in Journal of medicinal chemistry (01.12.1992)
Published in Journal of medicinal chemistry (01.12.1992)
Get full text
Journal Article