Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity
McKeithan, Wesley L., Feyen, Dries A.M., Bruyneel, Arne A.N., Okolotowicz, Karl J., Ryan, Daniel A., Sampson, Kevin J., Potet, Franck, Savchenko, Alex, Gómez-Galeno, Jorge, Vu, Michelle, Serrano, Ricardo, George, Alfred L., Kass, Robert S., Cashman, John R., Mercola, Mark
Published in Cell stem cell (05.11.2020)
Published in Cell stem cell (05.11.2020)
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Journal Article
Chronic High‐Fat Feeding Affects the Mesenchymal Cell Population Expanded From Adipose Tissue but Not Cardiac Atria
Perbellini, Filippo, Gomes, Renata S.M., Vieira, Silvia, Buchanan, Dougal, Malandraki-Miller, Sophia, Bruyneel, Arne A.N., Sousa Fialho, Maria da Luz, Ball, Vicky, Clarke, Kieran, Faggian, Giuseppe, Carr, Carolyn A.
Published in Stem cells translational medicine (01.12.2015)
Published in Stem cells translational medicine (01.12.2015)
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Journal Article
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy
Perea-Gil, Isaac, Seeger, Timon, Bruyneel, Arne A N, Termglinchan, Vittavat, Monte, Emma, Lim, Esther W, Vadgama, Nirmal, Furihata, Takaaki, Gavidia, Alexandra A, Arthur Ataam, Jennifer, Bharucha, Nike, Martinez-Amador, Noel, Ameen, Mohamed, Nair, Pooja, Serrano, Ricardo, Kaur, Balpreet, Feyen, Dries A M, Diecke, Sebastian, Snyder, Michael P, Metallo, Christian M, Mercola, Mark, Karakikes, Ioannis
Published in European heart journal (21.09.2022)
Published in European heart journal (21.09.2022)
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Journal Article
A deep learning platform to assess drug proarrhythmia risk
Serrano, Ricardo, Feyen, Dries A.M., Bruyneel, Arne A.N., Hnatiuk, Anna P., Vu, Michelle M., Amatya, Prashila L., Perea-Gil, Isaac, Prado, Maricela, Seeger, Timon, Wu, Joseph C., Karakikes, Ioannis, Mercola, Mark
Published in Cell stem cell (05.01.2023)
Published in Cell stem cell (05.01.2023)
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Journal Article
Reengineering Ponatinib to Minimize Cardiovascular Toxicity
Hnatiuk, Anna P, Bruyneel, Arne A N, Tailor, Dhanir, Pandrala, Mallesh, Dheeraj, Arpit, Li, Wenqi, Serrano, Ricardo, Feyen, Dries A M, Vu, Michelle M, Amatya, Prashila, Gupta, Saloni, Nakauchi, Yusuke, Morgado, Isabel, Wiebking, Volker, Liao, Ronglih, Porteus, Matthew H, Majeti, Ravindra, Malhotra, Sanjay V, Mercola, Mark
Published in Cancer research (Chicago, Ill.) (03.08.2022)
Published in Cancer research (Chicago, Ill.) (03.08.2022)
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Journal Article
Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
Hurtado, Cecilia, Safarova, Alena, Smith, Michael, Chung, Raeeun, Bruyneel, Arne A. N., Gomez-Galeno, Jorge, Oswald, Franz, Larson, Christopher J., Cashman, John R., Ruiz-Lozano, Pilar, Janiak, Philip, Suzuki, Teri, Mercola, Mark
Published in Scientific reports (25.07.2019)
Published in Scientific reports (25.07.2019)
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Journal Article
AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes
Bruyneel, Arne A N, Colas, Alexandre R, Karakikes, Ioannis, Mercola, Mark
Published in PloS one (26.12.2019)
Published in PloS one (26.12.2019)
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Journal Article
Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes
Lopez, Colleen A., Al-Siddiqi, Heba Hussain A. A., Purnama, Ujang, Iftekhar, Sonia, Bruyneel, Arne A. N., Kerr, Matthew, Nazir, Rabia, da Luz Sousa Fialho, Maria, Malandraki-Miller, Sophia, Alonaizan, Rita, Kermani, Fatemeh, Heather, Lisa C., Czernuszka, Jan, Carr, Carolyn A.
Published in Scientific reports (08.04.2021)
Published in Scientific reports (08.04.2021)
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Journal Article
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes
McKeithan, Wesley L, Savchenko, Alex, Yu, Michael S, Cerignoli, Fabio, Bruyneel, Arne A N, Price, Jeffery H, Colas, Alexandre R, Miller, Evan W, Cashman, John R, Mercola, Mark
Published in Frontiers in physiology (11.10.2017)
Published in Frontiers in physiology (11.10.2017)
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Journal Article
Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
Bruyneel, Arne A. N., Sehgal, Apurv, Malandraki-Miller, Sophia, Carr, Carolyn
Published in Journal of cardiovascular translational research (01.12.2016)
Published in Journal of cardiovascular translational research (01.12.2016)
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Journal Article
Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness
Cheng, Jiongjia, Tsuda, Masanao, Okolotowicz, Karl, Dwyer, Mary, Bushway, Paul J., Colas, Alexandre R., Lancman, Joseph J., Schade, Dennis, Perea-Gil, Isaac, Bruyneel, Arne A.N., Lee, Jaechol, Vadgama, Nirmal, Quach, Justine, McKeithan, Wesley L., Biechele, Travis L., Wu, Joseph C., Moon, Randall T., Si Dong, P. Duc, Karakikes, Ioannis, Cashman, John R., Mercola, Mark
Published in Cell chemical biology (20.05.2021)
Published in Cell chemical biology (20.05.2021)
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Journal Article
Using iPSC Models to Probe Regulation of Cardiac Ion Channel Function
Bruyneel, Arne A. N., McKeithan, Wesley L., Feyen, Dries A. M., Mercola, Mark
Published in Current cardiology reports (01.07.2018)
Published in Current cardiology reports (01.07.2018)
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Journal Article