Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication
Guignet, Michelle, Dhakal, Kiran, Flannery, Brenna M., Hobson, Brad A., Zolkowska, Dorota, Dhir, Ashish, Bruun, Donald A., Li, Shuyang, Wahab, Abdul, Harvey, Danielle J., Silverman, Jill L., Rogawski, Michael A., Lein, Pamela J.
Published in Neurobiology of disease (01.01.2020)
Published in Neurobiology of disease (01.01.2020)
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Time- and region-dependent blood-brain barrier impairment in a rat model of organophosphate-induced status epilepticus
Bernardino, Pedro N., Hobson, Brad A., Huddleston, Sydney L., Andrew, Peter M., MacMahon, Jeremy A., Saito, Naomi H., Porter, Valerie A., Bruun, Donald A., Harvey, Danielle J., Garbow, Joel R., Gelli, Angie, Chaudhari, Abhijit J., Lein, Pamela J.
Published in Neurobiology of disease (15.10.2023)
Published in Neurobiology of disease (15.10.2023)
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Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior
Yang, Dongren, Lauridsen, Holly, Buels, Kalmia, Chi, Lai-Har, La Du, Jane, Bruun, Donald A, Olson, James R, Tanguay, Robert L, Lein, Pamela J
Published in Toxicological sciences (01.05.2011)
Published in Toxicological sciences (01.05.2011)
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Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos
Berg, Elizabeth L, Ching, Tianna M, Bruun, Donald A, Rivera, Josef K, Careaga, Milo, Ellegood, Jacob, Lerch, Jason P, Wöhr, Markus, Lein, Pamela J, Silverman, Jill L
Published in Journal of neurodevelopmental disorders (01.12.2020)
Published in Journal of neurodevelopmental disorders (01.12.2020)
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Journal Article
Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain
Tsai, Yi-Hua, González, Eduardo A, Grodzki, Ana C G, Bruun, Donald A, Saito, Naomi H, Harvey, Danielle J, Lein, Pamela J
Published in Frontiers in toxicology (30.04.2024)
Published in Frontiers in toxicology (30.04.2024)
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Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine
Zolkowska, Dorota, Banks, Christopher N, Dhir, Ashish, Inceoglu, Bora, Sanborn, James R, McCoy, Mark R, Bruun, Donald A, Hammock, Bruce D, Lein, Pamela J, Rogawski, Michael A
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
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Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs
Bruun, Donald A., Ma, Betty, Chen, Yi‐Je, Wu, Chun‐Yi, Aleman, Monica, Zolkowska, Dorota, Smiley‐Jewell, Suzette M., Rogawski, Michael A., Lein, Pamela J.
Published in Epilepsia open (01.06.2023)
Published in Epilepsia open (01.06.2023)
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Cardiovascular and core temperature responses to acute organophosphate intoxication in rats
Pan, Shiyue, Bruun, Donald A, Lein, Pamela J, Chen, Chao
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Cardiovascular responses of adult male Sprague–Dawley rats following acute organophosphate intoxication and post-exposure treatment with midazolam with or without allopregnanolone
Pan, Shiyue, Bruun, Donald A., Lein, Pamela J., Chen, Chao-Yin
Published in Archives of toxicology (01.04.2024)
Published in Archives of toxicology (01.04.2024)
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Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication
Bruun, Donald A., Guignet, Michelle, Harvey, Danielle J., Lein, Pamela J.
Published in Neurotoxicology (Park Forest South) (01.07.2019)
Published in Neurotoxicology (Park Forest South) (01.07.2019)
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Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate
Supasai, Suangsuda, González, Eduardo A., Rowland, Douglas J., Hobson, Brad, Bruun, Donald A., Guignet, Michelle A., Soares, Sergio, Singh, Vikrant, Wulff, Heike, Saito, Naomi, Harvey, Danielle J., Lein, Pamela J.
Published in European journal of pharmacology (05.11.2020)
Published in European journal of pharmacology (05.11.2020)
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Journal Article
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate‐induced status epilepticus in rats
Dhir, Ashish, Bruun, Donald A., Guignet, Michelle, Tsai, Yi‐Hua, González, Eduardo, Calsbeek, Jonas, Vu, Joan, Saito, Naomi, Tancredi, Daniel J., Harvey, Danielle J., Lein, Pamela J., Rogawski, Michael A.
Published in Annals of the New York Academy of Sciences (01.11.2020)
Published in Annals of the New York Academy of Sciences (01.11.2020)
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A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures
Hobson, Brad A., Rowland, Douglas J., Dou, Yimeng, Saito, Naomi, Harmany, Zachary T., Bruun, Donald A., Harvey, Danielle J., Chaudhari, Abhijit J., Garbow, Joel R., Lein, Pamela J.
Published in Neuropharmacology (15.06.2024)
Published in Neuropharmacology (15.06.2024)
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Quantitative T2 mapping-based longitudinal assessment of brain injury and therapeutic rescue in the rat following acute organophosphate intoxication
Almeida, Alita Jesal D., Hobson, Brad A., Saito, Naomi, Bruun, Donald A., Porter, Valerie A., Harvey, Danielle J., Garbow, Joel R., Chaudhari, Abhijit J., Lein, Pamela J.
Published in Neuropharmacology (15.05.2024)
Published in Neuropharmacology (15.05.2024)
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Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets
Yang, Jun, Bruun, Donald A., Wang, Chang, Wan, Debin, McReynolds, Cindy B., Phu, Kenny, Inceoglu, Bora, Lein, Pamela J., Hammock, Bruce D.
Published in Toxicology and applied pharmacology (01.11.2019)
Published in Toxicology and applied pharmacology (01.11.2019)
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Journal Article
Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication
Flannery, Brenna M, Bruun, Donald A, Rowland, Douglas J, Banks, Christopher N, Austin, Adam T, Kukis, David L, Li, Yonggang, Ford, Byron D, Tancredi, Daniel J, Silverman, Jill L, Cherry, Simon R, Lein, Pamela J
Published in Journal of neuroinflammation (12.10.2016)
Published in Journal of neuroinflammation (12.10.2016)
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Journal Article
TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat
Hobson, Brad A, Rowland, Douglas J, Sisó, Sílvia, Guignet, Michelle A, Harmany, Zachary T, Bandara, Suren B, Saito, Naomi, Harvey, Danielle J, Bruun, Donald A, Garbow, Joel R, Chaudhari, Abhijit J, Lein, Pamela J
Published in Toxicological sciences (01.08.2019)
Published in Toxicological sciences (01.08.2019)
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Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents
Pessah, Isaac N., Rogawski, Michael A., Tancredi, Daniel J., Wulff, Heike, Zolkowska, Dorota, Bruun, Donald A., Hammock, Bruce D., Lein, Pamela J.
Published in Annals of the New York Academy of Sciences (01.08.2016)
Published in Annals of the New York Academy of Sciences (01.08.2016)
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