Target engagement of the first-in-class CXCR7 antagonist ACT-1004-1239 following multiple-dose administration in mice and humans
Huynh, Christine, Brussee, Janneke M., Pouzol, Laetitia, Fonseca, Marlene, Meyer zu Schwabedissen, Henriette E., Dingemanse, Jasper, Sidharta, Patricia N.
Published in Biomedicine & pharmacotherapy (01.12.2021)
Published in Biomedicine & pharmacotherapy (01.12.2021)
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Journal Article
Insufficient Stability of Clavulanic Acid in Widely Used Child-Appropriate Formulations
Mack, Ines, Sharland, Mike, Brussee, Janneke M, Rehm, Sophia, Rentsch, Katharina, Bielicki, Julia
Published in Antibiotics (Basel) (23.02.2021)
Published in Antibiotics (Basel) (23.02.2021)
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Journal Article
Population pharmacokinetics of the dual endothelin receptor antagonist aprocitentan in subjects with or without essential or resistant hypertension
Brussee, Janneke M., Sidharta, Patricia N., Dingemanse, Jasper, Krause, Andreas
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2024)
Published in Journal of pharmacokinetics and pharmacodynamics (01.06.2024)
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Journal Article
Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection
Brussee, Janneke M, Hiroshige, Noemi, Neodo, Anna, Coulibaly, Jean T, Pfister, Marc, Keiser, Jennifer
Published in Antimicrobial agents and chemotherapy (20.01.2021)
Published in Antimicrobial agents and chemotherapy (20.01.2021)
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Journal Article
Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults
Hofmann, Daniela, Brussee, Janneke M, Schulz, Jessica D, Coulibaly, Jean T, Pfister, Marc, Keiser, Jennifer
Published in Journal of antimicrobial chemotherapy (31.03.2022)
Published in Journal of antimicrobial chemotherapy (31.03.2022)
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Journal Article
Pharmacometric Analysis of Tribendimidine Monotherapy and Combination Therapies To Achieve High Cure Rates in Patients with Hookworm Infections
Brussee, Janneke M, Neodo, Anna, Schulz, Jessica D, Coulibaly, Jean T, Pfister, Marc, Keiser, Jennifer
Published in Antimicrobial agents and chemotherapy (20.01.2021)
Published in Antimicrobial agents and chemotherapy (20.01.2021)
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Journal Article
Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children
Vet, Nienke J, Brussee, Janneke M, de Hoog, Matthijs, Mooij, Miriam G, Verlaat, Carin W M, Jerchel, Isabel S, van Schaik, Ron H N, Koch, Birgit C P, Tibboel, Dick, Knibbe, Catherijne A J, de Wildt, Saskia N
Published in American journal of respiratory and critical care medicine (01.07.2016)
Published in American journal of respiratory and critical care medicine (01.07.2016)
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Journal Article
Simultaneous Pharmacokinetic Modeling of Gentamicin, Tobramycin and Vancomycin Clearance from Neonates to Adults: Towards a Semi-physiological Function for Maturation in Glomerular Filtration
De Cock, Roosmarijn F. W., Allegaert, Karel, Brussee, Janneke M., Sherwin, Catherine M. T., Mulla, Hussain, de Hoog, Matthijs, van den Anker, Johannes N., Danhof, Meindert, Knibbe, Catherijne A. J.
Published in Pharmaceutical research (01.10.2014)
Published in Pharmaceutical research (01.10.2014)
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Journal Article
Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach
Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., Palić, Semra, Brill, Margreke J. E., Barrett, Jeffrey S., Rostami-Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Published in Pharmaceutical research (01.09.2018)
Published in Pharmaceutical research (01.09.2018)
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Journal Article
Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure
Brussee, Janneke M., Vet, Nienke J., Krekels, Elke H. J., Valkenburg, Abraham J., Jacqz‐Aigrain, Evelyne, Gerven, Joop M. A., Swart, Eleonora L., Anker, Johannes N., Tibboel, Dick, Hoog, Matthijs, Wildt, Saskia N., Knibbe, Catherijne A. J.
Published in British journal of clinical pharmacology (01.02.2018)
Published in British journal of clinical pharmacology (01.02.2018)
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Journal Article
A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children
Brussee, Janneke M., Krekels, Elke H. J., Calvier, Elisa A. M., Palić, Semra, Rostami-Hodjegan, Amin, Danhof, Meindert, Barrett, Jeffrey S., de Wildt, Saskia N., Knibbe, Catherijne A. J.
Published in The AAPS journal (27.06.2019)
Published in The AAPS journal (27.06.2019)
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Journal Article
Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria
Brussee, Janneke M, Yeo, Tsin W, Lampah, Daniel A, Anstey, Nicholas M, Duffull, Stephen B
Published in Antimicrobial agents and chemotherapy (01.01.2016)
Published in Antimicrobial agents and chemotherapy (01.01.2016)
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Journal Article
First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates
Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., de Roos, Berend, Brill, Margreke J. E., van den Anker, Johannes N., Rostami‐Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Published in CPT: pharmacometrics and systems pharmacology (01.06.2018)
Published in CPT: pharmacometrics and systems pharmacology (01.06.2018)
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Journal Article
Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children
Vet, Nienke J., Brussee, Janneke M., de Hoog, Matthijs, Mooij, Miriam G., Verlaat, Carin W. M., Jerchel, Isabel S., van Schaik, Ron H. N., Koch, Birgit C. P., Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.
Published in American journal of respiratory and critical care medicine (01.07.2016)
Published in American journal of respiratory and critical care medicine (01.07.2016)
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Journal Article
Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modeling
Brussee, Janneke M, Calvier, Elisa A M, Krekels, Elke H J, Välitalo, Pyry A J, Tibboel, Dick, Allegaert, Karel, Knibbe, Catherijne A J
Published in Expert review of clinical pharmacology (01.09.2016)
Published in Expert review of clinical pharmacology (01.09.2016)
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Journal Article
ORGAN FAILURE AND C-REACTIVE PROTEIN BOTH AFFECT MIDAZOLAM CLEARANCE IN CRITICALLY ILL CHILDREN: A POPULATION PK MODEL
Vet, Nienke J, Brussee, Janneke M, de Hoog, Matthijs, Mooij, Miriam G, Verlaat, Carin WM, Tibboel, Dick, AJ Knibbe, Catherijne, de Wildt, Saskia N
Published in Archives of disease in childhood (01.01.2016)
Published in Archives of disease in childhood (01.01.2016)
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Journal Article