Strategies for durable β cell replacement in type 1 diabetes
Brusko, Todd M, Russ, Holger A, Stabler, Cherie L
Published in Science (American Association for the Advancement of Science) (30.07.2021)
Published in Science (American Association for the Advancement of Science) (30.07.2021)
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Normalization of CD4+ T cell metabolism reverses lupus
Yin, Yiming, Choi, Seung-Chul, Xu, Zhiwei, Perry, Daniel J, Seay, Howard, Croker, Byron P, Sobel, Eric S, Brusko, Todd M, Morel, Laurence
Published in Science translational medicine (11.02.2015)
Published in Science translational medicine (11.02.2015)
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Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
Choi, Seung-Chul, Titov, Anton A., Abboud, Georges, Seay, Howard R., Brusko, Todd M., Roopenian, Derry C., Salek-Ardakani, Shahram, Morel, Laurence
Published in Nature communications (22.10.2018)
Published in Nature communications (22.10.2018)
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Metformin Inhibits the Type 1 IFN Response in Human CD4 + T Cells
Titov, Anton A, Baker, Henry V, Brusko, Todd M, Sobel, Eric S, Morel, Laurence
Published in The Journal of immunology (1950) (15.07.2019)
Published in The Journal of immunology (1950) (15.07.2019)
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Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
Battaglia, Manuela, Ahmed, Simi, Anderson, Mark S, Atkinson, Mark A, Becker, Dorothy, Bingley, Polly J, Bosi, Emanuele, Brusko, Todd M, DiMeglio, Linda A, Evans-Molina, Carmella, Gitelman, Stephen E, Greenbaum, Carla J, Gottlieb, Peter A, Herold, Kevan C, Hessner, Martin J, Knip, Mikael, Jacobsen, Laura, Krischer, Jeffrey P, Long, S Alice, Lundgren, Markus, McKinney, Eoin F, Morgan, Noel G, Oram, Richard A, Pastinen, Tomi, Peters, Michael C, Petrelli, Alessandra, Qian, Xiaoning, Redondo, Maria J, Roep, Bart O, Schatz, Desmond, Skibinski, David, Peakman, Mark
Published in Diabetes care (01.01.2020)
Published in Diabetes care (01.01.2020)
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The immunology of type 1 diabetes
Herold, Kevan C., Delong, Thomas, Perdigoto, Ana Luisa, Biru, Noah, Brusko, Todd M., Walker, Lucy S. K.
Published in Nature reviews. Immunology (01.06.2024)
Published in Nature reviews. Immunology (01.06.2024)
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Journal Article
Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances
Ahmed, Simi, Cerosaletti, Karen, James, Eddie, Long, S Alice, Mannering, Stuart, Speake, Cate, Nakayama, Maki, Tree, Timothy, Roep, Bart O, Herold, Kevan C, Brusko, Todd M
Published in Diabetes (New York, N.Y.) (01.07.2019)
Published in Diabetes (New York, N.Y.) (01.07.2019)
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Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
Golovina, Tatiana N, Mikheeva, Tatiana, Brusko, Todd M, Blazar, Bruce R, Bluestone, Jeffrey A, Riley, James L
Published in PloS one (06.01.2011)
Published in PloS one (06.01.2011)
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Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226
Fuhrman, Christopher A, Yeh, Wen-I, Seay, Howard R, Saikumar Lakshmi, Priya, Chopra, Gaurav, Zhang, Lin, Perry, Daniel J, McClymont, Stephanie A, Yadav, Mahesh, Lopez, Maria-Cecilia, Baker, Henry V, Zhang, Ying, Li, Yizheng, Whitley, Maryann, von Schack, David, Atkinson, Mark A, Bluestone, Jeffrey A, Brusko, Todd M
Published in The Journal of immunology (1950) (01.07.2015)
Published in The Journal of immunology (1950) (01.07.2015)
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Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
Putnam, Amy L, Brusko, Todd M, Lee, Michael R, Liu, Weihong, Szot, Gregory L, Ghosh, Taumoha, Atkinson, Mark A, Bluestone, Jeffrey A
Published in Diabetes (New York, N.Y.) (01.03.2009)
Published in Diabetes (New York, N.Y.) (01.03.2009)
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Central Role for Interleukin-2 in Type 1 Diabetes
HULME, Maigan A, WASSERFALL, Clive H, ATKINSON, Mark A, BRUSKO, Todd M
Published in Diabetes (New York, N.Y.) (01.01.2012)
Published in Diabetes (New York, N.Y.) (01.01.2012)
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Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells
Shapiro, Melanie R., Peters, Leeana D., Brown, Matthew E., Cabello-Kindelan, Cecilia, Posgai, Amanda L., Bayer, Allison L., Brusko, Todd M.
Published in The Journal of immunology (1950) (01.10.2023)
Published in The Journal of immunology (1950) (01.10.2023)
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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
McClymont, Stephanie A, Putnam, Amy L, Lee, Michael R, Esensten, Jonathan H, Liu, Weihong, Hulme, Maigan A, Hoffmüller, Ulrich, Baron, Udo, Olek, Sven, Bluestone, Jeffrey A, Brusko, Todd M
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Poon, Maya M L, Rybkina, Ksenia, Kato, Yu, Kubota, Masaru, Matsumoto, Rei, Bloom, Nathaniel I, Zhang, Zeli, Hastie, Kathryn M, Grifoni, Alba, Weiskopf, Daniela, Wells, Steven B, Ural, Basak B, Lam, Nora, Szabo, Peter A, Dogra, Pranay, Lee, Yoon S, Gray, Joshua I, Bradley, Marissa C, Brusko, Maigan A, Brusko, Todd M, Saphire, Erica O, Connors, Thomas J, Sette, Alessandro, Crotty, Shane, Farber, Donna L
Published in Science immunology (19.11.2021)
Published in Science immunology (19.11.2021)
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Type 1 Interferons Potentiate Human CD8 + T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway
Newby, Brittney N, Brusko, Todd M, Zou, Baiming, Atkinson, Mark A, Clare-Salzler, Michael, Mathews, Clayton E
Published in Diabetes (New York, N.Y.) (01.12.2017)
Published in Diabetes (New York, N.Y.) (01.12.2017)
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Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis
Shapiro, Melanie R, Wasserfall, Clive H, McGrail, Sean M, Posgai, Amanda L, Bacher, Rhonda, Muir, Andrew, Haller, Michael J, Schatz, Desmond A, Wesley, Johnna D, von Herrath, Matthias, Hagopian, William A, Speake, Cate, Atkinson, Mark A, Brusko, Todd M
Published in Diabetes (New York, N.Y.) (01.03.2020)
Published in Diabetes (New York, N.Y.) (01.03.2020)
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A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells
Van Gool, Frédéric, Nguyen, Michelle L.T., Mumbach, Maxwell R., Satpathy, Ansuman T., Rosenthal, Wendy L., Giacometti, Simone, Le, Duy T., Liu, Weihong, Brusko, Todd M., Anderson, Mark S., Rudensky, Alexander Y., Marson, Alexander, Chang, Howard Y., Bluestone, Jeffrey A.
Published in Immunity (Cambridge, Mass.) (19.02.2019)
Published in Immunity (Cambridge, Mass.) (19.02.2019)
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A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes
Guirgis, Faheem W, Black, Lauren Page, Henson, Morgan, Labilloy, Guillaume, Smotherman, Carmen, Hopson, Charlotte, Tfirn, Ian, DeVos, Elizabeth L, Leeuwenburgh, Christiaan, Moldawer, Lyle, Datta, Susmita, Brusko, Todd M, Hester, Alexis, Bertrand, Andrew, Grijalva, Victor, Arango-Esterhay, Alexander, Moore, Frederick A, Reddy, Srinivasa T
Published in Critical care (London, England) (17.09.2021)
Published in Critical care (London, England) (17.09.2021)
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