1,2,4-Triazolo[1,5-a]pyrimidines in drug design
Oukoloff, Killian, Lucero, Bobby, Francisco, Karol R., Brunden, Kurt R., Ballatore, Carlo
Published in European journal of medicinal chemistry (01.03.2019)
Published in European journal of medicinal chemistry (01.03.2019)
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Journal Article
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
He, Zhuohao, Guo, Jing L, McBride, Jennifer D, Narasimhan, Sneha, Kim, Hyesung, Changolkar, Lakshmi, Zhang, Bin, Gathagan, Ronald J, Yue, Cuiyong, Dengler, Christopher, Stieber, Anna, Nitla, Magdalena, Coulter, Douglas A, Abel, Ted, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M-Y
Published in Nature medicine (01.01.2018)
Published in Nature medicine (01.01.2018)
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Journal Article
Structure Property Relationships of Carboxylic Acid Isosteres
Lassalas, Pierrik, Gay, Bryant, Lasfargeas, Caroline, James, Michael J, Tran, Van, Vijayendran, Krishna G, Brunden, Kurt R, Kozlowski, Marisa C, Thomas, Craig J, Smith, Amos B, Huryn, Donna M, Ballatore, Carlo
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models
Sankaranarayanan, Sethu, Barten, Donna M, Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S, Cacace, Angela, Albright, Charles F, Meredith, Jr, Jere, Trojanowski, John Q, Lee, Virginia M-Y, Brunden, Kurt R, Ahlijanian, Michael
Published in PloS one (01.05.2015)
Published in PloS one (01.05.2015)
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Journal Article
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
Luk, Kelvin C, Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2009)
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Journal Article
GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome
Pi, Min, Chen, Ling, Huang, Min-Zhao, Zhu, Wenyu, Ringhofer, Brian, Luo, Junming, Christenson, Lane, Li, Benyi, Zhang, Jianghong, Jackson, P David, Faber, Pieter, Brunden, Kurt R, Harrington, John J, Quarles, L Darryl
Published in PloS one (03.12.2008)
Published in PloS one (03.12.2008)
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Journal Article
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
CRAMER, Paige E, CIRRITO, John R, BRUNDEN, Kurt R, WILSON, Donald A, LANDRETH, Gary E, WESSON, Daniel W, DANIEL LEE, C. Y, COLLEEN KARLO, J, ZINN, Adriana E, CASALI, Brad T, RESTIVO, Jessica L, GOEBET, Whitney D, JAMES, Michael J
Published in Science (American Association for the Advancement of Science) (23.03.2012)
Published in Science (American Association for the Advancement of Science) (23.03.2012)
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Journal Article
Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies
Ballatore, Carlo, Brunden, Kurt R, Huryn, Donna M, Trojanowski, John Q, Lee, Virginia M.-Y, Smith, Amos B
Published in Journal of medicinal chemistry (08.11.2012)
Published in Journal of medicinal chemistry (08.11.2012)
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Journal Article
Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y
Published in Nature reviews. Drug discovery (01.10.2009)
Published in Nature reviews. Drug discovery (01.10.2009)
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Journal Article
Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy
Carroll, Jenna C, Iba, Michiyo, Bangasser, Debra A, Valentino, Rita J, James, Michael J, Brunden, Kurt R, Lee, Virginia M-Y, Trojanowski, John Q
Published in The Journal of neuroscience (05.10.2011)
Published in The Journal of neuroscience (05.10.2011)
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Journal Article
Therapeutic strategies for the treatment of tauopathies: Hopes and challenges
Khanna, Mansi R, Kovalevich, Jane, Lee, Virginia M.-Y, Trojanowski, John Q, Brunden, Kurt R
Published in Alzheimer's & dementia (01.10.2016)
Published in Alzheimer's & dementia (01.10.2016)
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Journal Article
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A, Mercken, Marc, Brunden, Kurt R, Trojanowski, John Q, Dewachter, Ilse, Lee, Virginia M.Y, Moechars, Diederik
Published in Neurobiology of disease (01.01.2015)
Published in Neurobiology of disease (01.01.2015)
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Journal Article
Characterization of tau binding by gosuranemab
Sopko, Richelle, Golonzhka, Olga, Arndt, Joseph, Quan, Chao, Czerkowicz, Julie, Cameron, Andrew, Smith, Benjamin, Murugesan, Yogapriya, Gibbons, Garrett, Kim, Soo-Jung, Trojanowski, John Q., Lee, Virginia M.Y., Brunden, Kurt R., Graham, Danielle L., Weinreb, Paul H., Hering, Heike
Published in Neurobiology of disease (01.12.2020)
Published in Neurobiology of disease (01.12.2020)
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Journal Article
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
Zhang, Bin, Carroll, Jenna, Trojanowski, John Q, Yao, Yuemang, Iba, Michiyo, Potuzak, Justin S, Hogan, Anne-Marie L, Xie, Sharon X, Ballatore, Carlo, Smith, 3rd, Amos B, Lee, Virginia M-Y, Brunden, Kurt R
Published in The Journal of neuroscience (14.03.2012)
Published in The Journal of neuroscience (14.03.2012)
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Journal Article
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
Brunden, Kurt R, Zhang, Bin, Carroll, Jenna, Yao, Yuemang, Potuzak, Justin S, Hogan, Anne-Marie L, Iba, Michiyo, James, Michael J, Xie, Sharon X, Ballatore, Carlo, Smith, 3rd, Amos B, Lee, Virginia M-Y, Trojanowski, John Q
Published in The Journal of neuroscience (13.10.2010)
Published in The Journal of neuroscience (13.10.2010)
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Journal Article
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease
Uemura, Maiko T., Robinson, John L., Cousins, Katheryn A. Q., Tropea, Thomas F., Kargilis, Daniel C., McBride, Jennifer D., Suh, EunRan, Xie, Sharon X., Xu, Yan, Porta, Sílvia, Uemura, Norihito, Van Deerlin, Vivianna M., Wolk, David A., Irwin, David J., Brunden, Kurt R., Lee, Virginia M.-Y., Lee, Edward B., Trojanowski, John Q.
Published in Acta neuropathologica (01.01.2022)
Published in Acta neuropathologica (01.01.2022)
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