Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)
Yang, Dewen, Xie, Zhiyong, Stephenson, Diane, Morton, Daniel, Hicks, Carol D., Brown, Tracy M., Sriram, Renuka, O'Neill, Sharon, Raunig, David, Bocan, Thomas
Published in NeuroImage (Orlando, Fla.) (14.02.2011)
Published in NeuroImage (Orlando, Fla.) (14.02.2011)
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Journal Article
Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139
Lanz, Thomas A, Karmilowicz, Michael J, Wood, Kathleen M, Pozdnyakov, Nikolay, Du, Ping, Piotrowski, Mary A, Brown, Tracy M, Nolan, Charles E, Richter, Karl E G, Finley, James E, Fei, Qing, Ebbinghaus, Charles F, Chen, Yuhpyng L, Spracklin, Douglas K, Tate, Barbara, Geoghegan, Kieran F, Lau, Lit-Fui, Auperin, David D, Schachter, Joel B
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
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Journal Article
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014
Lanz, Thomas A, Wood, Kathleen M, Richter, Karl E G, Nolan, Charles E, Becker, Stacey L, Pozdnyakov, Nikolay, Martin, Barbara-Anne, Du, Ping, Oborski, Christine E, Wood, Douglas E, Brown, Tracy M, Finley, James E, Sokolowski, Sharon A, Hicks, Carol D, Coffman, Karen J, Geoghegan, Kieran F, Brodney, Michael A, Liston, Dane, Tate, Barbara
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
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Journal Article
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014
Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Wood, Douglas E., Wood, Kathleen M., Van Deusen, Jeffrey W., Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models
Lanz, Thomas A., Salatto, Christopher T., Semproni, Anthony R., Marconi, Michael, Brown, Tracy M., Richter, Karl E.G., Schmidt, Kari, Nelson, Frederick R., Schachter, Joel B.
Published in Biochemical pharmacology (01.03.2008)
Published in Biochemical pharmacology (01.03.2008)
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Journal Article
Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease
Brodney, Michael A., Auperin, David D., Becker, Stacey L., Bronk, Brian S., Brown, Tracy M., Coffman, Karen J., Finley, James E., Hicks, Carol D., Karmilowicz, Michael J., Lanz, Thomas A., Liston, Dane, Liu, Xingrong, Martin, Barbara-Anne, Nelson, Robert B., Nolan, Charles E., Oborski, Christine E., Parker, Christine P., Richter, Karl E.G., Pozdnyakov, Nikolay, Sahagan, Barbara G., Schachter, Joel B., Sokolowski, Sharon A., Tate, Barbara, Van Deusen, Jeffrey W., Wood, Douglas E., Wood, Kathleen M.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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Journal Article
Characterization of rTg4510 mice yields evidence of significant neuroinflammation
Robshaw, Ashley E, Kawabe, Thomas T, Caouette, David, Brown, Tracy M, Soares, Holly D, Hicks, Carol D, Milici, Anthony J, JoAnn Dumin
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Common pathways and cellular processes as revealed by computational analysis of expression patterns from Tg4510 mice and human Alzheimer brains
Zagouras, Panayiotis, Poland, Bradley W, Naik, Snehal, Kawabe, Thomas T, Brown, Tracy M, Peitzsch, Robert M, Hicks, Carol D, Milici, Anthony J
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Transgene dependent, doxycycline-sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation
Roof, Robin L, Yabe, Yoko, Brown, Tracy M, McCarthy, Sheryl A, Bales, Kelly R, Hicks, Carol D
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Overexpression of human tau induces loss of synaptic markers and requires phosphorylation of tau in the microtubule binding domain
Hicks, Carol D, Brown, Tracy M, Kimmel, Lida H, Kleiman, Robin J, Richter, Karl E.G, Loos, Paula
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
P1‐146: Transgene dependent, doxycycline‐sensitive cognitive deficits in Tg4510 mutant mouse correlate with insoluble tau epitope accumulation
Roof, Robin L., Yabe, Yoko, Brown, Tracy M., McCarthy, Sheryl A., Bales, Kelly R., Hicks, Carol D.
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
P1‐337: Overexpression of human tau induces loss of synaptic markers and requires phosphorylation of tau in the microtubule binding domain
Hicks, Carol D., Brown, Tracy M., Kimmel, Lida H., Kleiman, Robin J., Richter, Karl E.G., Loos, Paula
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
P1‐163: Characterization of rTg4510 mice yields evidence of significant neuroinflammation
Robshaw, Ashley E., Kawabe, Thomas T., Caouette, David, Brown, Tracy M., Soares, Holly D., Hicks, Carol D., Milici, Anthony J., JoAnn Dumin
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
P1‐140: Common pathways and cellular processes as revealed by computational analysis of expression patterns from Tg4510 mice and human Alzheimer brains
Zagouras, Panayiotis, Poland, Bradley W., Naik, Snehal, Kawabe, Thomas T., Brown, Tracy M., Peitzsch, Robert M., Hicks, Carol D., Milici, Anthony J.
Published in Alzheimer's & dementia (01.07.2010)
Published in Alzheimer's & dementia (01.07.2010)
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Journal Article
Concentration-Dependent Modulation of Amyloid-β in Vivo and in Vitro Using the γ-Secretase Inhibitor, LY-450139
Thomas A. Lanz, Michael J. Karmilowicz, Kathleen M. Wood, Nikolay Pozdnyakov, Ping Du, Mary A. Piotrowski, Tracy M. Brown, Charles E. Nolan, Karl E. G. Richter, James E. Finley, Qing Fei, Charles F. Ebbinghaus, Yuhpyng L. Chen, Douglas K. Spracklin, Barbara Tate, Kieran F. Geoghegan, Lit-Fui Lau, David D. Auperin, Joel B. Schachter
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2006)
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Journal Article
Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models
Lanz, Thomas A, Salatto, Christopher T, Semproni, Anthony R, Marconi, Michael, Brown, Tracy M, Richter, Karl E G, Schmidt, Kari, Nelson, Frederick R, Schachter, Joel B
Published in Biochemical pharmacology (01.03.2008)
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Published in Biochemical pharmacology (01.03.2008)
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