High-throughput mouse phenomics for characterizing mammalian gene function
Brown, Steve D. M., Holmes, Chris C., Mallon, Ann-Marie, Meehan, Terrence F., Smedley, Damian, Wells, Sara
Published in Nature reviews. Genetics (01.06.2018)
Published in Nature reviews. Genetics (01.06.2018)
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Multivariate phenotype analysis enables genome-wide inference of mammalian gene function
Nicholson, George, Morgan, Hugh, Ganjgahi, Habib, Brown, Steve D M, Mallon, Ann-Marie, Holmes, Chris
Published in PLoS biology (09.08.2022)
Published in PLoS biology (09.08.2022)
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Journal Article
Helios is a key transcriptional regulator of outer hair cell maturation
Chessum, Lauren, Matern, Maggie S., Kelly, Michael C., Johnson, Stuart L., Ogawa, Yoko, Milon, Beatrice, McMurray, Mark, Driver, Elizabeth C., Parker, Andrew, Song, Yang, Codner, Gemma, Esapa, Christopher T., Prescott, Jack, Trent, Graham, Wells, Sara, Dragich, Abigail K., Frolenkov, Gregory I., Kelley, Matthew W., Marcotti, Walter, Brown, Steve D. M., Elkon, Ran, Bowl, Michael R., Hertzano, Ronna
Published in Nature (London) (01.11.2018)
Published in Nature (London) (01.11.2018)
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Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair
Mianné, Joffrey, Chessum, Lauren, Kumar, Saumya, Aguilar, Carlos, Codner, Gemma, Hutchison, Marie, Parker, Andrew, Mallon, Ann-Marie, Wells, Sara, Simon, Michelle M, Teboul, Lydia, Brown, Steve D M, Bowl, Michael R
Published in Genome medicine (15.02.2016)
Published in Genome medicine (15.02.2016)
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Journal Article
Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing
Newton, Sherylanne, Kong, Fanbo, Carlton, Adam J, Aguilar, Carlos, Parker, Andrew, Codner, Gemma F, Teboul, Lydia, Wells, Sara, Brown, Steve D M, Marcotti, Walter, Bowl, Michael R
Published in PLoS genetics (31.01.2022)
Published in PLoS genetics (31.01.2022)
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Journal Article
CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
Giese, Arnaud P. J., Tang, Yi-Quan, Sinha, Ghanshyam P., Bowl, Michael R., Goldring, Adam C., Parker, Andrew, Freeman, Mary J., Brown, Steve D. M., Riazuddin, Saima, Fettiplace, Robert, Schafer, William R., Frolenkov, Gregory I., Ahmed, Zubair M.
Published in Nature communications (29.06.2017)
Published in Nature communications (29.06.2017)
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Journal Article
Quiet as a mouse: dissecting the molecular and genetic basis of hearing
Brown, Steve D. M, Hardisty-Hughes, Rachel E, Mburu, Philomena
Published in Nature reviews. Genetics (01.04.2008)
Published in Nature reviews. Genetics (01.04.2008)
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A holistic view of mouse enhancer architectures reveals analogous pleiotropic effects and correlation with human disease
Sethi, Siddharth, Vorontsov, Ilya E, Kulakovskiy, Ivan V, Greenaway, Simon, Williams, John, Makeev, Vsevolod J, Brown, Steve D M, Simon, Michelle M, Mallon, Ann-Marie
Published in BMC genomics (02.11.2020)
Published in BMC genomics (02.11.2020)
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Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes
Higgins, Kendall, Moore, Bret A., Berberovic, Zorana, Adissu, Hibret A., Eskandarian, Mohammad, Flenniken, Ann M., Shao, Andy, Imai, Denise M., Clary, Dave, Lanoue, Louise, Newbigging, Susan, Nutter, Lauryl M. J., Adams, David J., Bosch, Fatima, Braun, Robert E., Brown, Steve D. M., Dickinson, Mary E., Dobbie, Michael, Flicek, Paul, Gao, Xiang, Galande, Sanjeev, Grobler, Anne, Heaney, Jason D., Herault, Yann, de Angelis, Martin Hrabe, Chin, Hsian-Jean Genie, Mammano, Fabio, Qin, Chuan, Shiroishi, Toshihiko, Sedlacek, Radislav, Seong, J.-K., Xu, Ying, Lloyd, K. C. Kent, McKerlie, Colin, Moshiri, Ala
Published in Scientific reports (01.12.2022)
Published in Scientific reports (01.12.2022)
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Journal Article
Unraveling the genetics of otitis media: from mouse to human and back again
Rye, Marie S, Bhutta, Mahmood F, Cheeseman, Michael T, Burgner, David, Blackwell, Jenefer M, Brown, Steve D. M, Jamieson, Sarra E
Published in Mammalian genome (01.02.2011)
Published in Mammalian genome (01.02.2011)
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Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
Nicod, Jérôme, Davies, Robert W, Cai, Na, Hassett, Carl, Goodstadt, Leo, Cosgrove, Cormac, Yee, Benjamin K, Lionikaite, Vikte, McIntyre, Rebecca E, Remme, Carol Ann, Lodder, Elisabeth M, Gregory, Jennifer S, Hough, Tertius, Joynson, Russell, Phelps, Hayley, Nell, Barbara, Rowe, Clare, Wood, Joe, Walling, Alison, Bopp, Nasrin, Bhomra, Amarjit, Hernandez-Pliego, Polinka, Callebert, Jacques, Aspden, Richard M, Talbot, Nick P, Robbins, Peter A, Harrison, Mark, Fray, Martin, Launay, Jean-Marie, Pinto, Yigal M, Blizard, David A, Bezzina, Connie R, Adams, David J, Franken, Paul, Weaver, Tom, Wells, Sara, Brown, Steve D M, Potter, Paul K, Klenerman, Paul, Lionikas, Arimantas, Mott, Richard, Flint, Jonathan
Published in Nature genetics (01.08.2016)
Published in Nature genetics (01.08.2016)
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Journal Article
High-throughput discovery of genetic determinants of circadian misalignment
Zhang, Tao, Xie, Pancheng, Dong, Yingying, Liu, Zhiwei, Zhou, Fei, Pan, Dejing, Huang, Zhengyun, Zhai, Qiaocheng, Gu, Yue, Wu, Qingyu, Tanaka, Nobuhiko, Obata, Yuichi, Bradley, Allan, Lelliott, Christopher J, Nutter, Lauryl M J, McKerlie, Colin, Flenniken, Ann M, Champy, Marie-France, Sorg, Tania, Herault, Yann, Angelis, Martin Hrabe De, Durner, Valerie Gailus, Mallon, Ann-Marie, Brown, Steve D M, Meehan, Terry, Parkinson, Helen E, Smedley, Damian, Lloyd, K C Kent, Yan, Jun, Gao, Xiang, Seong, Je Kyung, Wang, Chi-Kuang Leo, Sedlacek, Radislav, Liu, Yi, Rozman, Jan, Yang, Ling, Xu, Ying
Published in PLoS genetics (13.01.2020)
Published in PLoS genetics (13.01.2020)
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Journal Article
Introduction to Mammalian Genome Special Issue: Mammalian Genetic Resources
Brown, Steve D. M., Nadeau, Joseph H., Wells, Sara, Mallon, Ann-Marie, Teboul, Lydia, Tuggle, Christopher K., Schook, Lawrence B.
Published in Mammalian genome (01.03.2022)
Published in Mammalian genome (01.03.2022)
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Journal Article
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Koscielny, Gautier, Yaikhom, Gagarine, Iyer, Vivek, Meehan, Terrence F, Morgan, Hugh, Atienza-Herrero, Julian, Blake, Andrew, Chen, Chao-Kung, Easty, Richard, Di Fenza, Armida, Fiegel, Tanja, Grifiths, Mark, Horne, Alan, Karp, Natasha A, Kurbatova, Natalja, Mason, Jeremy C, Matthews, Peter, Oakley, Darren J, Qazi, Asfand, Regnart, Jack, Retha, Ahmad, Santos, Luis A, Sneddon, Duncan J, Warren, Jonathan, Westerberg, Henrik, Wilson, Robert J, Melvin, David G, Smedley, Damian, Brown, Steve D M, Flicek, Paul, Skarnes, William C, Mallon, Ann-Marie, Parkinson, Helen
Published in Nucleic acids research (01.01.2014)
Published in Nucleic acids research (01.01.2014)
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Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans
Mallon, Ann-Marie, Iyer, Vivek, Melvin, David, Morgan, Hugh, Parkinson, Helen, Brown, Steve D. M, Flicek, Paul, Skarnes, William C
Published in Mammalian genome (01.10.2012)
Published in Mammalian genome (01.10.2012)
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Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway
Esapa, Christopher T, Piret, Sian E, Nesbit, M Andrew, Loh, Nellie Y, Thomas, Gethin, Croucher, Peter I, Brown, Matthew A, Brown, Steve D M, Cox, Roger D, Thakker, Rajesh V
Published in PloS one (13.12.2016)
Published in PloS one (13.12.2016)
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Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness
Carlton, Adam J., Halford, Julia, Underhill, Anna, Jeng, Jing‐Yi, Avenarius, Matthew R., Gilbert, Merle L., Ceriani, Federico, Ebisine, Kimimuepigha, Brown, Steve D. M., Bowl, Michael R., Barr‐Gillespie, Peter G., Marcotti, Walter
Published in The Journal of physiology (01.02.2021)
Published in The Journal of physiology (01.02.2021)
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