Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X‑ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)‑4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, Niels, Delgar, Claudia G, Koch, Karina, Brown, Patricia M. G. E, Møller, Charlotte, Han, Liwei, Huynh, Tri H. V, Hansen, Stinne W, Nielsen, Birgitte, Bowie, Derek, Pickering, Darryl S, Kastrup, Jette Sandholm, Frydenvang, Karla, Bunch, Lennart
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
Get full text
Journal Article
Single-particle cryo-EM at atomic resolution
Nakane, Takanori, Kotecha, Abhay, Sente, Andrija, McMullan, Greg, Masiulis, Simonas, Brown, Patricia M G E, Grigoras, Ioana T, Malinauskaite, Lina, Malinauskas, Tomas, Miehling, Jonas, Uchański, Tomasz, Yu, Lingbo, Karia, Dimple, Pechnikova, Evgeniya V, de Jong, Erwin, Keizer, Jeroen, Bischoff, Maarten, McCormack, Jamie, Tiemeijer, Peter, Hardwick, Steven W, Chirgadze, Dimitri Y, Murshudov, Garib, Aricescu, A Radu, Scheres, Sjors H W
Published in Nature (London) (05.11.2020)
Published in Nature (London) (05.11.2020)
Get full text
Journal Article
Binding Mode of an α‑Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1
Demmer, Charles S, Møller, Charlotte, Brown, Patricia M. G. E, Han, Liwei, Pickering, Darryl S, Nielsen, Birgitte, Bowie, Derek, Frydenvang, Karla, Kastrup, Jette S, Bunch, Lennart
Published in ACS chemical neuroscience (17.06.2015)
Published in ACS chemical neuroscience (17.06.2015)
Get full text
Journal Article
Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation
Brown, Patricia M G E, McGuire, Hugo, Bowie, Derek
Published in The Journal of general physiology (02.01.2018)
Published in The Journal of general physiology (02.01.2018)
Get full text
Journal Article
Functional Validation of Heteromeric Kainate Receptor Models
Paramo, Teresa, Brown, Patricia M.G.E., Musgaard, Maria, Bowie, Derek, Biggin, Philip C.
Published in Biophysical journal (21.11.2017)
Published in Biophysical journal (21.11.2017)
Get full text
Journal Article
α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells
Accardi, Michael V, Brown, Patricia M G E, Miraucourt, Loïs S, Orser, Beverley A, Bowie, Derek
Published in The Journal of neuroscience (01.07.2015)
Published in The Journal of neuroscience (01.07.2015)
Get full text
Journal Article
Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor
Khanra, Nandish, Brown, Patricia Mge, Perozzo, Amanda M, Bowie, Derek, Meyerson, Joel R
Published in eLife (16.03.2021)
Published in eLife (16.03.2021)
Get full text
Journal Article
Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the lonotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GIuK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, Niels, Delgar, Claudia G., Koch, Karina, Brown, Patricia M. G. E., Moller, Charlotte, Han, Liwei, Huynh, Tri H. V., Hansen, Stinne W., Nielsen, Birgitte, Bowie, Derek, Pickering, Darryl S., Kastrup, Jette Sandholm, Frydenvang, Karla, Bunch, Lennart
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
Get full text
Journal Article
Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission
Accardi, Michael V., Daniels, Bryan A., Brown, Patricia M.G.E., Fritschy, Jean-Marc, Tyagarajan, Shiva K., Bowie, Derek
Published in Nature communications (16.01.2014)
Published in Nature communications (16.01.2014)
Get full text
Journal Article