Delineating the role of cooperativity in the design of potent PROTACs for BTK
Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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A covalent BTK ternary complex compatible with targeted protein degradation
Schiemer, James, Maxwell, Andrew, Horst, Reto, Liu, Shenping, Uccello, Daniel P., Borzilleri, Kris, Rajamohan, Nisha, Brown, Matthew F., Calabrese, Matthew F.
Published in Nature communications (02.03.2023)
Published in Nature communications (02.03.2023)
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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
Flanagan, Mark E, Blumenkopf, Todd A, Brissette, William H, Brown, Matthew F, Casavant, Jeffrey M, Shang-Poa, Chang, Doty, Jonathan L, Elliott, Eileen A, Fisher, Michael B, Hines, Michael, Kent, Craig, Kudlacz, Elizabeth M, Lillie, Brett M, Magnuson, Kelly S, McCurdy, Sandra P, Munchhof, Michael J, Perry, Bret D, Sawyer, Perry S, Strelevitz, Timothy J, Subramanyam, Chakrapani, Sun, Jianmin, Whipple, David A, Changelian, Paul S
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa
Tomaras, Andrew P, Crandon, Jared L, McPherson, Craig J, Banevicius, Mary Anne, Finegan, Steven M, Irvine, Rebecca L, Brown, Matthew F, O'Donnell, John P, Nicolau, David P
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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CCR1 antagonists: what have we learned from clinical trials
Gladue, Ronald P, Brown, Matthew F, Zwillich, Samuel H
Published in Current topics in medicinal chemistry (01.09.2010)
Published in Current topics in medicinal chemistry (01.09.2010)
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The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA
Sun, Jing, Sun, Quanhong, Brown, Matthew F, Dudgeon, Crissy, Chandler, Julie, Xu, Xiang, Shu, Yongqian, Zhang, Lin, Yu, Jian
Published in PloS one (17.08.2012)
Published in PloS one (17.08.2012)
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LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens
Tomaras, Andrew P, McPherson, Craig J, Kuhn, Michael, Carifa, Arlene, Mullins, Lisa, George, David, Desbonnet, Charlene, Eidem, Tess M, Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Miller, Alita A, O'Donnell, John P
Published in mBio (30.09.2014)
Published in mBio (30.09.2014)
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Fensome, Andrew, Ambler, Catherine M, Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F, Chrencik, Jill, Clark, James D, Dowty, Martin E, Efremov, Ivan V, Flick, Andrew, Gerstenberger, Brian S, Gopalsamy, Ariamala, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Jussif, Jason, Knafels, John D, Limburg, David C, Lin, David, Lin, Tsung H, Pierce, Betsy S, Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T, Telliez, Jean-Baptiste, Trujillo, John I, Vajdos, Felix F, Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors
BOICHUK, Sergei, LEE, Derek J, ZEWE, James, TAGUCHI, Takahiro, KUAN, Shin-Fan, SCHÖFFSKI, Patrick, DEBIEC-RYCHTER, Maria, DUENSING, Anette, MEHALEK, Keith R, MAKIELSKI, Kathleen R, WOZNIAK, Agnieszka, SENEVIRATNE, Danushka S, KORZENIEWSKI, Nina, CUEVAS, Rolando, PARRY, Joshua A, BROWN, Matthew F
Published in Cancer research (Chicago, Ill.) (15.02.2014)
Published in Cancer research (Chicago, Ill.) (15.02.2014)
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Delivering on the promise of protein degraders
O’Brien Laramy, Matthew N., Luthra, Suman, Brown, Matthew F., Bartlett, Derek W.
Published in Nature reviews. Drug discovery (01.05.2023)
Published in Nature reviews. Drug discovery (01.05.2023)
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Assessing Post-Traumatic Tonic Immobility Responses: The Scale for Tonic Immobility Occurring Post-Trauma
Lloyd, Chantelle S., Lanius, Ruth A., Brown, Matthew F., Neufeld, Richard J., Frewen, Paul A., McKinnon, Margaret C.
Published in Chronic stress (Thousand Oaks, Calif.) (2019)
Published in Chronic stress (Thousand Oaks, Calif.) (2019)
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Unraveling the Ties that Bind: Social Anxiety is Differentially Related to Vulnerable and Grandiose Narcissistic Traits
Villalongo Andino, Mara, Hauenstein, Neil, Stanton, Kasey, Brown, Matthew F. D., Richey, John A.
Published in Journal of psychopathology and behavioral assessment (01.06.2024)
Published in Journal of psychopathology and behavioral assessment (01.06.2024)
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