Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88
O'Carroll, Ailís, Chauvin, Brieuc, Brown, James W P, Meagher, Ava, Coyle, Joanne, Schill, Jurgen, Bhumkhar, Akshay, Hunter, Dominic J B, Ve, Thomas, Kobe, Bostjan, Sierecki, Emma, Gambin, Yann
Published in BMC biology (24.12.2018)
Published in BMC biology (24.12.2018)
Get full text
Journal Article
Single-molecule detection on a portable 3D-printed microscope
Brown, James W. P., Bauer, Arnaud, Polinkovsky, Mark E, Bhumkar, Akshay, Hunter, Dominic J. B., Gaus, Katharina, Sierecki, Emma, Gambin, Yann
Published in Nature communications (11.12.2019)
Published in Nature communications (11.12.2019)
Get full text
Journal Article
Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor
Brown, James W. P, Alford, Rokiah G, Walsh, James C, Spinney, Richard E, Xu, Stephanie Y, Hertel, Sophie, Berengut, Jonathan F, Spenkelink, Lisanne M, van Oijen, Antoine M, Böcking, Till, Morris, Richard G, Lee, Lawrence K
Published in ACS nano (26.04.2022)
Published in ACS nano (26.04.2022)
Get full text
Journal Article
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Galvagnion, Céline, Brown, James W. P., Ouberai, Myriam M., Flagmeier, Patrick, Vendruscolo, Michele, Buell, Alexander K., Sparr, Emma, Dobson, Christopher M.
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Get full text
Journal Article
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Cox, Dezerae, Whiten, Daniel R., Brown, James W.P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M., Ecroyd, Heath
Published in The Journal of biological chemistry (23.03.2018)
Published in The Journal of biological chemistry (23.03.2018)
Get full text
Journal Article
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
Brown, James W P, Meisl, Georg, Knowles, Tuomas P J, Buell, Alexander K, Dobson, Christopher M, Galvagnion, Céline
Published in Chemical communications (Cambridge, England) (10.07.2018)
Published in Chemical communications (Cambridge, England) (10.07.2018)
Get full text
Journal Article
β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
Brown, James W. P., Buell, Alexander K., Michaels, Thomas C. T., Meisl, Georg, Carozza, Jacqueline, Flagmeier, Patrick, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Galvagnion, Céline
Published in Scientific reports (03.11.2016)
Published in Scientific reports (03.11.2016)
Get full text
Journal Article
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrilsElectronic supplementary information (ESI) available: Materials and methods, supplementary figure. See DOI: 10.1039/c8cc03002b
Brown, James W. P, Meisl, Georg, Knowles, Tuomas P. J, Buell, Alexander K, Dobson, Christopher M, Galvagnion, Céline
Year of Publication 10.07.2018
Year of Publication 10.07.2018
Get full text
Journal Article
Viral M45 and necroptosis‐associated proteins form heteromeric amyloid assemblies
Pham, Chi LL, Shanmugam, Nirukshan, Strange, Merryn, O'Carroll, Ailis, Brown, James WP, Sierecki, Emma, Gambin, Yann, Steain, Megan, Sunde, Margaret
Published in EMBO reports (01.02.2019)
Published in EMBO reports (01.02.2019)
Get full text
Journal Article
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of a-synuclein
Galvagnion, Céline, Brown, James W P, Ouberai, Myriam M, Flagmeier, Patrick, Vendruscolo, Michele, Buell, Alexander K, Sparr, Emma, Dobson, Christopher M
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (28.06.2016)
Journal Article
[beta]-Synuclein suppresses both the initiation and amplification steps of [alpha]-synuclein aggregation via competitive binding to surfaces
Brown, James W P, Buell, Alexander K, Michaels, Thomas C T, Meisl, Georg, Carozza, Jacqueline, Flagmeier, Patrick, Vendruscolo, Michele, Knowles, Tuomas P J, Dobson, Christopher M, Galvagnion, Céline
Published in Scientific reports (01.11.2016)
Published in Scientific reports (01.11.2016)
Get full text
Journal Article