Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures
Roberts, Brittany L T, Patel, Kinaree, Brown, Hilda H, Borchelt, David R
Published in PloS one (31.10.2012)
Published in PloS one (31.10.2012)
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A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo
Prudencio, Mercedes, Lelie, Herman, Brown, Hilda H., Whitelegge, Julian P., Valentine, Joan S., Borchelt, David R.
Published in Journal of neurochemistry (01.05.2012)
Published in Journal of neurochemistry (01.05.2012)
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Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model
Tebbenkamp, Andrew T N, Crosby, Keith W, Siemienski, Zoe B, Brown, Hilda H, Golde, Todd E, Borchelt, David R
Published in PloS one (07.12.2012)
Published in PloS one (07.12.2012)
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Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative
Tebbenkamp, Andrew T.N., Green, Cameron, Xu, Guilian, Denovan-Wright, Eileen M., Rising, Aaron C., Fromholt, Susan E., Brown, Hilda H., Swing, Debbie, Mandel, Ronald J., Tessarollo, Lino, Borchelt, David R.
Published in Human molecular genetics (15.07.2011)
Published in Human molecular genetics (15.07.2011)
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Experimental Mutagenesis of Huntingtin to Map Cleavage Sites: Different Outcomes in Cell and Mouse Models
Tebbenkamp, Andrew T.N., Xu, Guilian, Siemienski, Zoe B., Janus, Christopher, Fromholt, Susan E., Brown, Hilda H., Swing, Debbie, Tessarollo, Lino, Borchelt, David R.
Published in Journal of Huntington's disease (2014)
Published in Journal of Huntington's disease (2014)
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A novel variant of human SOD1 harboring ALS-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo
Prudencio, Mercedes, Lelie, Herman, Brown, Hilda H., Whitelegge, Julian P., Valentine, Joan S., Borchelt, David R.
Published in Journal of neurochemistry (20.03.2012)
Published in Journal of neurochemistry (20.03.2012)
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