Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 8. Pharmacological Optimization of Orally Bioavailable 2-Pyridone-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Johnson, Theodore O, Hua, Ye, Luu, Hiep T, Sakata, Sylvie K, Brown, Edward L, Maldonado, Fausto C, Tuntland, Tove, Lee, Caroline A, Fuhrman, Shella A, Zalman, Leora S, Patick, Amy K, Matthews, David A, Wu, Ellen Y, Guo, Ming, Borer, Bennett C, Nayyar, Naresh K, Moran, Terence, Chen, Lijian, Rejto, Paul A, Rose, Peter W, Guzman, Mark C, Dovalsantos, Elena Z, Lee, Steven, McGee, Kevin, Mohajeri, Michael, Liese, Andreas, Tao, Junhua, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Wu, Zhen Ping, Liu, Jia, Meador, James W, Ferre, Rose Ann
Published in Journal of medicinal chemistry (09.10.2003)
Published in Journal of medicinal chemistry (09.10.2003)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Brown, Edward L, Maldonado, Fausto C, Fuhrman, Shella A, Zalman, Leora S, Tuntland, Tove, Lee, Caroline A, Patick, Amy K, Matthews, David A, Hendrickson, Thomas F, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Sakata, Sylvie K, Chen, Lijian, Guzman, Mark C, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P1 Lactam Moieties as l-Glutamine Replacements
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Webber, Stephen E, Marakovits, Joseph T, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Ford, Clifford E, Burke, Benjamin J, Rejto, Paul A, Hendrickson, Thomas F, Tuntland, Tove, Brown, Edward L, Meador, James W, Ferre, Rose Ann, Harr, James E. V, Kosa, Maha B, Worland, Stephen T
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics
Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Johnson, Theodore O., Brown, Edward L., Maldonado, Fausto C., Fuhrman, Shella A., Zalman, Leora S., Patick, Amy K., Matthews, David A., Hou, Xinjun, Meador, James W., Ferre, Rose Ann, Worland, Stephen T.
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
Published in Bioorganic & medicinal chemistry letters (11.03.2002)
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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease
Webber, Stephen E., Tikhe, Jayashree, Worland, Stephen T., Fuhrman, Shella A., Hendrickson, Thomas F., Matthews, David A., Love, Robert A., Patick, Amy K., Meador, James W., Ferre, Rose Ann, Brown, Edward L., DeLisle, Dorothy M., Ford, Clifford E., Binford, Susan L.
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Structure-Based Design of a Parallel Synthetic Array Directed Toward the Discovery of Irreversible Inhibitors of Human Rhinovirus 3C Protease
Johnson, Theodore O, Hua, Ye, Luu, Hiep T, Brown, Edward L, Chan, Fora, Chu, Shao Song, Dragovich, Peter S, Eastman, Brian W, Ferre, Rose Ann, Fuhrman, Shella A, Hendrickson, Thomas F, Maldonado, Fausto C, Matthews, David A, Meador, James W, Patick, Amy K, Reich, Siegfried H, Skalitzky, Donald J, Worland, Stephen T, Yang, Michelle, Zalman, Leora S
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements
Webber, Stephen E, Okano, Koji, Little, Thomas L, Reich, Siegfried H, Xin, Yue, Fuhrman, Shella A, Matthews, David A, Love, Robert A, Hendrickson, Thomas F, Patick, Amy K, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Ford, Clifford E, Binford, Susan L, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease: Structure-Based Design, Synthesis, and Biological Evaluation
Reich, Siegfried H, Johnson, Theodore, Wallace, Michael B, Kephart, Susan E, Fuhrman, Shella A, Worland, Stephen T, Matthews, David A, Hendrickson, Thomas F, Chan, Fora, Meador, James, Ferre, Rose Ann, Brown, Edward L, DeLisle, Dorothy M, Patick, Amy K, Binford, Susan L, Ford, Clifford E
Published in Journal of medicinal chemistry (04.05.2000)
Published in Journal of medicinal chemistry (04.05.2000)
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Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
DRAGOVICH, P. S, RU ZHOU, MEADOR, J. W, PATICK, A. K, FORD, C. E, BROTHERS, M. A, BINFORD, S. L, MATTHEWS, D. A, FERRE, R. A, WORLAND, S. T, WEBBER, S. E, PRINS, T. J, KWOK, A. K, OKANO, K, FUHRMAN, S. A, ZALMAN, L. S, MALDONADO, F. C, BROWN, E. L
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
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An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents
Ettinger, Anna, Ostroff, Rachel, Rhihanek, Marynette, Dragovich, Peter S, Zalman, Leora S, Patick, Amy K, Prins, Thomas J, Fuhrman, Shella A, Brown, Edward L, Worland, Stephen T, Polisky, Barry
Published in Antiviral research (01.03.2004)
Published in Antiviral research (01.03.2004)
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Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Journal Article
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P-1 lactam moieties as L-glutamine replacements
Dragovich, PS, Prins, TJ, Zhou, R, Webber, SE, Marakovits, JT, Fuhrman, SA, Patick, AK, Matthews, DA, Lee, CA, Ford, CE, Burke, BJ, Rejto, PA, Hendrickson, TF, Tuntland, T, Brown, EL, Meador, JW, Ferre, RA, Harr, JEV, Kosa, MB, Worland, ST
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Journal Article
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: Design, synthesis, biological evaluation, and cocrystal structure solution of P-1 glutamine isosteric replacements
Webber, SE, Okano, K, Little, TL, Reich, SH, Xin, Y, Fuhrman, SA, Matthews, DA, Love, RA, Hendrickson, TF, Patick, AK, Meador, JW, Ferre, RA, Brown, EL, Ford, CE, Binford, SL, Worland, ST
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies
Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Reich, Siegfried H, Prins, Thomas J, Marakovits, Joseph T, Littlefield, Ethel S, Zhou, Ru, Tikhe, Jayashree, Ford, Clifford E, Wallace, Michael B, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, Harr, James E. V, DeLisle, Dorothy M, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 2. Peptide Structure−Activity Studies
Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Reich, Siegfried H, Marakovits, Joseph T, Prins, Thomas J, Zhou, Ru, Tikhe, Jayashree, Littlefield, Ethel S, Bleckman, Ted M, Wallace, Michael B, Little, Thomas L, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, DeLisle, Dorothy M, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein
Ganguly, Ashit K, Wang, Yu-Sen, Pramanik, Birendra N, Doll, Ronald J, Snow, Mark E, Taveras, Arthur G, Remiszewski, Stacy, Cesarz, David, del Rosario, J, Vibulbhan, Bancha, Brown, Joan E, Kirschmeier, Paul, Huang, Eric C, Heimark, Larry, Tsarbopoulos, Anthony, Girijavallabhan, Viyyoor M, Aust, Robert M, Brown, Edward L, DeLisle, Dorothy M, Fuhrman, Shella A, Hendrickson, Thomas F, Kissinger, Charles R, Love, Robert A, Sisson, Wess A, Villafranca, J. Ernest, Webber, Steve E
Published in Biochemistry (Easton) (10.11.1998)
Published in Biochemistry (Easton) (10.11.1998)
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