Expanding the medicinal chemistry synthetic toolbox
Boström, Jonas, Brown, Dean G, Young, Robert J, Keserü, György M
Published in Nature reviews. Drug discovery (01.10.2018)
Published in Nature reviews. Drug discovery (01.10.2018)
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Journal Article
ESKAPEing the labyrinth of antibacterial discovery
Tommasi, Ruben, Brown, Dean G, Walkup, Grant K, Manchester, John I, Miller, Alita A
Published in Nature reviews. Drug discovery (01.08.2015)
Published in Nature reviews. Drug discovery (01.08.2015)
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Journal Article
Book Review
Impact of a five-dimensional framework on R&D productivity at AstraZeneca
Morgan, Paul, Brown, Dean G, Lennard, Simon, Anderton, Mark J, Barrett, J Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E, Matcham, James, Mettetal, Jerome, Nicholls, David J, Platz, Stefan, Rees, Steve, Snowden, Michael A, Pangalos, Menelas N
Published in Nature reviews. Drug discovery (01.03.2018)
Published in Nature reviews. Drug discovery (01.03.2018)
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Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
Silva, M Catarina, Nandi, Ghata A, Tentarelli, Sharon, Gurrell, Ian K, Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C, Brown, Dean G, Brandon, Nicholas J, Haggarty, Stephen J
Published in Nature communications (26.06.2020)
Published in Nature communications (26.06.2020)
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Journal Article
New natural products as new leads for antibacterial drug discovery
Brown, Dean G., Lister, Troy, May-Dracka, Tricia L.
Published in Bioorganic & medicinal chemistry letters (15.01.2014)
Published in Bioorganic & medicinal chemistry letters (15.01.2014)
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Journal Article
Clinical development times for innovative drugs
Brown, Dean G, Wobst, Heike J, Kapoor, Abhijeet, Kenna, Leslie A, Southall, Noel
Published in Nature reviews. Drug discovery (01.11.2022)
Published in Nature reviews. Drug discovery (01.11.2022)
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Journal Article
Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay
Nayar, Asha S, Dougherty, Thomas J, Ferguson, Keith E, Granger, Brett A, McWilliams, Lisa, Stacey, Clare, Leach, Lindsey J, Narita, Shin-ichiro, Tokuda, Hajime, Miller, Alita A, Brown, Dean G, McLeod, Sarah M
Published in Journal of bacteriology (01.05.2015)
Published in Journal of bacteriology (01.05.2015)
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Journal Article
Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase
Read, Jon, Collie, Iain T., Nguyen-McCarty, Michelle, Lucaj, Christopher, Robinson, James, Conway, Leslie, Mukherjee, Jayanta, McCall, Eileen, Donohoe, Gerard, Flavell, Elizabeth, Peciak, Karolina, Warwicker, Juli, Dix, Carly, Van den Hoven, Bernard G., Madin, Andrew, Brown, Dean G., Moss, Stephen, Haggarty, Stephen J., Brandon, Nicholas J., Bürli, Roland W.
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
Published in Bioorganic & medicinal chemistry letters (01.08.2019)
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Axl receptor tyrosine kinase is a regulator of apolipoprotein E
Zhao, Wenchen, Fan, Jianjia, Kulic, Iva, Koh, Cheryl, Clark, Amanda, Meuller, Johan, Engkvist, Ola, Barichievy, Samantha, Raynoschek, Carina, Hicks, Ryan, Maresca, Marcello, Wang, Qi, Brown, Dean G, Lok, Alvin, Parro, Cameron, Robert, Jerome, Chou, Hsien-Ya, Zuhl, Andrea M, Wood, Michael W, Brandon, Nicholas J, Wellington, Cheryl L
Published in Molecular brain (04.05.2020)
Published in Molecular brain (04.05.2020)
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Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition
Kennedy, Amanda J, Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K Y, Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G, Fairlie, David P, Dekker, Niek
Published in Communications biology (17.12.2020)
Published in Communications biology (17.12.2020)
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