A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome
Lu, Simin, Kanekura, Kohsuke, Hara, Takashi, Mahadevan, Jana, Spears, Larry D., Oslowski, Christine M., Martinez, Rita, Yamazaki-Inoue, Mayu, Toyoda, Masashi, Neilson, Amber, Blanner, Patrick, Brown, Cris M., Semenkovich, Clay F., Marshall, Bess A., Hershey, Tamara, Umezawa, Akihiro, Greer, Peter A., Urano, Fumihiko
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (09.12.2014)
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A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome
Mahadevan, Jana, Morikawa, Shuntaro, Yagi, Takuya, Abreu, Damien, Lu, Simin, Kanekura, Kohsuke, Brown, Cris M., Urano, Fumihiko
Published in Laboratory investigation (01.09.2020)
Published in Laboratory investigation (01.09.2020)
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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
Abreu, Damien, Stone, Stephen I, Pearson, Toni S, Bucelli, Robert C, Simpson, Ashley N, Hurst, Stacy, Brown, Cris M, Kries, Kelly, Onwumere, Chinyere, Gu, Hongjie, Hoekel, James, Tychsen, Lawrence, Van Stavern, Gregory P, White, Neil H, Marshall, Bess A, Hershey, Tamara, Urano, Fumihiko
Published in JCI insight (09.08.2021)
Published in JCI insight (09.08.2021)
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Genotype and clinical characteristics of patients with Wolfram syndrome and WFS1-related disorders
Lee, Evan M, Verma, Megha, Palaniappan, Nila, Pope, Emiko M, Lee, Sammie, Blacher, Lindsey, Neerumalla, Pooja, An, William, Campbell, Toko, Brown, Cris, Hurst, Stacy, Marshall, Bess, Hershey, Tamara, Nunes, Virginia, López de Heredia, Miguel, Urano, Fumihiko
Published in Frontiers in genetics (21.06.2023)
Published in Frontiers in genetics (21.06.2023)
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Multidimensional analysis and therapeutic development using patient iPSC-derived disease models of Wolfram syndrome
Kitamura, Rie Asada, Maxwell, Kristina G, Ye, Wenjuan, Kries, Kelly, Brown, Cris M, Augsornworawat, Punn, Hirsch, Yoel, Johansson, Martin M, Weiden, Tzvi, Ekstein, Joseph, Cohen, Joshua, Klee, Justin, Leslie, Kent, Simeonov, Anton, Henderson, Mark J, Millman, Jeffrey R, Urano, Fumihiko
Published in JCI insight (22.09.2022)
Published in JCI insight (22.09.2022)
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85-LB: A Phase 1b/2 Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome
ABREU, DAMIEN, PEARSON, TONI S., BUCELLI, ROBERT C., SIMPSON, ASHLEY, BROWN, CRIS M., KRIES, KELLY, GU, HONGJIE, STONE, STEPHEN I., TYCHSEN, LAWRENCE, STAVERN, GREGORY VAN, WHITE, NEIL H., MARSHALL, BESS A., HERSHEY, TAMARA, URANO, FUMIHIKO
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Targeting Cellular Calcium Homeostasis to Prevent Beta-Cell Death in Type 1 Diabetes
CLARK, AMY L., ABREU, DAMIEN, BROWN, CRIS M., URANO, FUMIHIKO
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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345-LB: Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF): A New Therapeutic Target for Wolfram Syndrome
MORIKAWA, SHUNTARO, MAHADEVAN, JANA, YAGI, TAKUYA, ABREU, DAMIEN, KANEKURA, KOHSUKE, BROWN, CRIS M., URANO, FUMIHIKO
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Functional Characterization of Wolfram Syndrome 1 Protein in ß-Cell Function and Viability
ABREU, DAMIEN, LAVAGNINO, ZENO, BROWN, CRIS M., PISTON, DAVID W., URANO, FUMIHIKO
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
Gorgogietas, Vyron, Rajaei, Bahareh, Heeyoung, Chae, Santacreu, Bruno J., Marín-Cañas, Sandra, Salpea, Paraskevi, Sawatani, Toshiaki, Musuaya, Anyishai, Arroyo, María N., Moreno-Castro, Cristina, Benabdallah, Khadija, Demarez, Celine, Toivonen, Sanna, Cosentino, Cristina, Pachera, Nathalie, Lytrivi, Maria, Cai, Ying, Carnel, Lode, Brown, Cris, Urano, Fumihiko, Marchetti, Piero, Gilon, Patrick, Eizirik, Decio L., Cnop, Miriam, Igoillo-Esteve, Mariana
Published in Diabetologia (01.07.2023)
Published in Diabetologia (01.07.2023)
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Wolframin is a novel regulator of tau pathology and neurodegeneration
Chen, Shuo, Acosta, Diana, Li, Liangping, Liang, Jiawen, Chang, Yuzhou, Wang, Cankun, Fitzgerald, Julie, Morrison, Cody, Goulbourne, Chris N., Nakano, Yoshi, Villegas, Nancy C. Hernandez, Venkataraman, Lalitha, Brown, Cris, Serrano, Geidy E., Bell, Erica, Wemlinger, Trina, Wu, Min, Kokiko-Cochran, Olga N., Popovich, Phillip, Flowers, Xena E., Honig, Lawrence S., Vonsattel, Jean Paul, Scharre, Douglas W., Beach, Thomas G., Ma, Qin, Kuret, Jeff, Kõks, Sulev, Urano, Fumihiko, Duff, Karen E., Fu, Hongjun
Published in Acta neuropathologica (01.05.2022)
Published in Acta neuropathologica (01.05.2022)
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eP264: Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome
Urano, Fumihiko, Kitamura, Rie Asada, Maxwell, Kristina, Ye, Wenjuan, Kries, Kelly, Brown, Cris, Augsornworawat, Punn, Johansson, Martin, Cohen, Joshua, Klee, Justin, Leslie, Kent, Simeonov, Anton, Hirsch, Joel, Weiden, Tzvi, Henderson, Mark, Millman, Jeffrey, Ekstein, Josef
Published in Genetics in medicine (01.03.2022)
Published in Genetics in medicine (01.03.2022)
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Deficiency of WFS1 increases vulnerability to pathological tau in vitro and in vivo: Molecular and cell biology/tau
Chen, Shuo, Venkaraman, Lalitha, Liang, Jiawen, Nakano, Yoshi, Villegas, Nancy E. Hernandez, Brown, Cris, Urano, Fumihiko, Koks, Sulev, Serrano, Geidy E., Beach, Thomas G., Davies, Peter, Diamond, Marc, Duff, Karen E., Fu, Hongjun
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
Deficiency of WFS1 increases vulnerability to pathological tau in vitro and in vivo
Chen, Shuo, Venkaraman, Lalitha, Liang, Jiawen, Nakano, Yoshi, Villegas, Nancy E. Hernandez, Brown, Cris, Urano, Fumihiko, Koks, Sulev, Serrano, Geidy E., Beach, Thomas G., Davies, Peter, Diamond, Marc, Duff, Karen E., Fu, Hongjun
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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The commission on social determinants of health: tackling the social roots of health inequities
Irwin, Alec, Valentine, Nicole, Brown, Chris, Loewenson, Rene, Solar, Orielle, Brown, Hilary, Koller, Theadora, Vega, Jeanette
Published in PLoS medicine (01.06.2006)
Published in PLoS medicine (01.06.2006)
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A phase 1b/2a clinical trial of dantrolene sodium in patients with Wolfram syndrome
Abreu, Damien, Stone, Stephen I., Pearson, Toni S., Bucelli, Robert C., Simpson, Ashley N., Hurst, Stacy, Brown, Cris M., Kries, Kelly, Onwumere, Chinyere, Gu, Hongjie, Hoekel, James, Tychsen, Lawrence, Van Stavern, Gregory P., White, Neil H., Marshall, Bess A., Hershey, Tamara, Urano, Fumihiko
Published in JCI insight (29.06.2021)
Published in JCI insight (29.06.2021)
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Journal Article
Genotype and Clinical Characteristics of Patients with Wolfram Syndrome and WFS1-related Disorders
Lee, Evan M, Verma, Megha, Palaniappan, Nila, Pope, Emiko M, Lee, Sammie, Blacher, Lindsey, Neerumalla, Pooja, An, William, Campbell, Toko, Brown, Cris, Hurst, Stacy, Marshall, Bess, Hershey, Tamara, Nunes, Virginia, de Heredia, Miguel López, Urano, Fumihiko
Published in medRxiv : the preprint server for health sciences (16.02.2023)
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Published in medRxiv : the preprint server for health sciences (16.02.2023)
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