Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans
Mancilla, Rodrigo, Brouwers, Bram, Schrauwen‐Hinderling, Vera B., Hesselink, Matthijs K. C., Hoeks, Joris, Schrauwen, Patrick
Published in Physiological reports (01.01.2021)
Published in Physiological reports (01.01.2021)
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The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity
Vanweert, Froukje, Boone, Sebastiaan C, Brouwers, Bram, Mook-Kanamori, Dennis O, de Mutsert, Renée, Rosendaal, Frits R, Lamb, Hildo J, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick, Hesselink, Matthijs K C, Phielix, Esther
Published in International Journal of Obesity (01.07.2021)
Published in International Journal of Obesity (01.07.2021)
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Journal Article
Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox
Daemen, Sabine, Gemmink, Anne, Brouwers, Bram, Meex, Ruth C.R., Huntjens, Peter R., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna, Hoeks, Joris, Schrauwen, Patrick, Hesselink, Matthijs K.C.
Published in Molecular metabolism (Germany) (01.11.2018)
Published in Molecular metabolism (Germany) (01.11.2018)
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Journal Article
Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes
Brouwers, Bram, Schrauwen-Hinderling, Vera B, Jelenik, Tomas, Gemmink, Anne, Havekes, Bas, Bruls, Yvonne, Dahlmans, Dennis, Roden, Michael, Hesselink, Matthijs K C, Schrauwen, Patrick
Published in Clinical science (1979) (01.08.2017)
Published in Clinical science (1979) (01.08.2017)
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Journal Article
Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?
Gemmink, Anne, Daemen, Sabine, Brouwers, Bram, Huntjens, Peter R., Schaart, Gert, Moonen‐Kornips, Esther, Jörgensen, Johanna, Hoeks, Joris, Schrauwen, Patrick, Hesselink, Matthijs K. C.
Published in The Journal of physiology (01.03.2018)
Published in The Journal of physiology (01.03.2018)
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Journal Article
Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection
Lindeboom, Lucas, Nabuurs, Christine I, Hoeks, Joris, Brouwers, Bram, Phielix, Esther, Kooi, M Eline, Hesselink, Matthijs K C, Wildberger, Joachim E, Stevens, Robert D, Koves, Timothy, Muoio, Deborah M, Schrauwen, Patrick, Schrauwen-Hinderling, Vera B
Published in The Journal of clinical investigation (01.11.2014)
Published in The Journal of clinical investigation (01.11.2014)
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Journal Article
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
Costford, Sheila R, Brouwers, Bram, Hopf, Meghan E, Sparks, Lauren M, Dispagna, Mauro, Gomes, Ana P, Cornnell, Heather H, Petucci, Chris, Phelan, Peter, Xie, Hui, Yi, Fanchao, Walter, Glenn A, Osborne, Timothy F, Sinclair, David A, Mynatt, Randall L, Ayala, Julio E, Gardell, Stephen J, Smith, Steven R
Published in Molecular metabolism (Germany) (01.01.2018)
Published in Molecular metabolism (Germany) (01.01.2018)
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Journal Article
Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training
Brouwers, Bram, Stephens, Natalie A, Costford, Sheila R, Hopf, Meghan E, Ayala, Julio E, Yi, Fanchao, Xie, Hui, Li, Jian-Liang, Gardell, Stephen J, Sparks, Lauren M, Smith, Steven R
Published in Frontiers in physiology (11.06.2018)
Published in Frontiers in physiology (11.06.2018)
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Journal Article
An improvement in skeletal muscle mitochondrial capacity with short‐term aerobic training is associated with changes in Tribbles 1 expression
Vega, Rick B., Brouwers, Bram, Parsons, Stephanie A., Stephens, Natalie A., Pino, Maria F., Hodges, Andrew, Yi, Fanchao, Yu, Gongxin, Pratley, Richard E., Smith, Steven R., Sparks, Lauren M.
Published in Physiological reports (01.06.2020)
Published in Physiological reports (01.06.2020)
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Journal Article
Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial
Gastaldelli, Amalia, Cusi, Kenneth, Fernández Landó, Laura, Bray, Ross, Brouwers, Bram, Rodríguez, Ángel
Published in The lancet. Diabetes & endocrinology (01.06.2022)
Published in The lancet. Diabetes & endocrinology (01.06.2022)
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Journal Article
Randomised clinical trial: Design of the SYNERGY‐NASH phase 2b trial to evaluate tirzepatide as a treatment for metabolic dysfunction‐associated steatohepatitis and modification of screening strategy to reduce screen failures
Vuppalanchi, Raj, Loomba, Rohit, Sanyal, Arun J., Nikooie, Amir, Tang, Yuanyuan, Robins, Deborah A., Brouwers, Bram, Hartman, Mark L.
Published in Alimentary pharmacology & therapeutics (01.07.2024)
Published in Alimentary pharmacology & therapeutics (01.07.2024)
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Journal Article
Incretin-based investigational therapies for the treatment of MASLD/MASH
Brouwers, Bram, Rao, Girish, Tang, Yuanyuan, Rodríguez, Ángel, Glass, Leonard C, Hartman, Mark L
Published in Diabetes research and clinical practice (01.05.2024)
Published in Diabetes research and clinical practice (01.05.2024)
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Journal Article
The roles of type 2 diabetes and obesity in disease activity and progression of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis
Shinde, Shraddha, Nelson, David R, Mitroi, Jessica, Heaton, Pamela C, Hincapie, Ana L, Brouwers, Bram
Published in Current medical research and opinion (2024)
Published in Current medical research and opinion (2024)
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Journal Article
LBO-001 Tirzepatide for the treatment of metabolic dysfunction-associated steatohepatitis with liver fibrosis: results of the SYNERGY-NASH phase 2 trial
Loomba, Rohit, Hartman, Mark, Lawitz, Eric, Vuppalanchi, Raj, Boursier, Jerome, Bugianesi, Elisabetta, Yoneda, Masato, Behling, Cynthia, Cummings, Oscar, Tang, Yuanyuan, Brouwers, Bram, Robins, Deborah, Nikooie, Amir, Bunck, Mathijs, Haupt, Axel, Sanyal, Arun J.
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity
Stinkens, Rudi, Brouwers, Bram, Jocken, Johan W, Blaak, Ellen E, Teunissen-Beekman, Karianna F, Hesselink, Matthijs K, van Baak, Marleen A, Schrauwen, Patrick, Goossens, Gijs H
Published in Journal of applied physiology (1985) (01.11.2018)
Published in Journal of applied physiology (1985) (01.11.2018)
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Journal Article
Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals
Gemmink, Anne, Daemen, Sabine, Brouwers, Bram, Hoeks, Joris, Schaart, Gert, Knoops, Kèvin, Schrauwen, Patrick, Hesselink, Matthijs K.C.
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2021)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.02.2021)
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Journal Article
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
Sanyal, Arun J, Kaplan, Lee M, Frias, Juan P, Brouwers, Bram, Wu, Qiwei, Thomas, Melissa K, Harris, Charles, Schloot, Nanette C, Du, Yu, Mather, Kieren J, Haupt, Axel, Hartman, Mark L
Published in Nature medicine (01.07.2024)
Published in Nature medicine (01.07.2024)
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Journal Article
Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes
Stephens, Natalie A, Brouwers, Bram, Eroshkin, Alexey M, Yi, Fanchao, Cornnell, Heather H, Meyer, Christian, Goodpaster, Bret H, Pratley, Richard E, Smith, Steven R, Sparks, Lauren M
Published in Diabetes care (01.10.2018)
Published in Diabetes care (01.10.2018)
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Journal Article
Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver
Brouwers, Bram, Schrauwen-Hinderling, Vera B, Jelenik, Tomas, Gemmink, Anne, Sparks, Lauren M, Havekes, Bas, Bruls, Yvonne, Dahlmans, Dennis, Roden, Michael, Hesselink, Matthijs K C, Schrauwen, Patrick
Published in American journal of physiology: endocrinology and metabolism (01.02.2018)
Published in American journal of physiology: endocrinology and metabolism (01.02.2018)
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Journal Article
Mild Exercise Does Not Prevent Atherosclerosis in APOE3‐Leiden.CETP Mice or Improve Lipoprotein Profile of Men with Obesity
In het Panhuis, Wietse, Kooijman, Sander, Brouwers, Bram, Verhoeven, Aswin, Pronk, Amanda C.M., Streefland, Trea C.M., Giera, Martin, Schrauwen, Patrick, Rensen, Patrick C.N., Schönke, Milena
Published in Obesity (Silver Spring, Md.) (01.07.2020)
Published in Obesity (Silver Spring, Md.) (01.07.2020)
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