Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells
Zuin, Jessica, Dixon, Jesse R., van der Reijden, Michael I. J. A., Ye, Zhen, Kolovos, Petros, Brouwer, Rutger W. W., van de Corput, Mariëtte P. C., van de Werken, Harmen J. G., Knoch, Tobias A., van IJcken, Wilfred F. J., Grosveld, Frank G., Ren, Bing, Wendt, Kerstin S.
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.2014)
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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states
Neagu, Alex, van Genderen, Emiel, Escudero, Irene, Verwegen, Lucas, Kurek, Dorota, Lehmann, Johannes, Stel, Jente, Dirks, René A. M., van Mierlo, Guido, Maas, Alex, Eleveld, Cindy, Ge, Yang, den Dekker, Alexander. T., Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Modic, Miha, Drukker, Micha, Jansen, Joop H., Rivron, Nicolas C., Baart, Esther B., Marks, Hendrik, ten Berge, Derk
Published in Nature cell biology (01.05.2020)
Published in Nature cell biology (01.05.2020)
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BMP4 and Temozolomide Synergize in the Majority of Patient-Derived Glioblastoma Cultures
Verploegh, Iris S C, Conidi, Andrea, El Hassnaoui, Hoesna, Verhoeven, Floor A M, Korporaal, Anne L, Ntafoulis, Ioannis, van den Hout, Mirjam C G N, Brouwer, Rutger W W, Lamfers, Martine L M, van IJcken, Wilfred F J, Huylebroeck, Danny, Leenstra, Sieger
Published in International journal of molecular sciences (22.09.2024)
Published in International journal of molecular sciences (22.09.2024)
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Journal Article
Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
Heshusius, Steven, Grech, Laura, Gillemans, Nynke, Brouwer, Rutger W. W., den Dekker, Xander T., van IJcken, Wilfred F. J., Nota, Benjamin, Felice, Alex E., van Dijk, Thamar B., von Lindern, Marieke, Borg, Joseph, van den Akker, Emile, Philipsen, Sjaak
Published in Scientific reports (10.01.2022)
Published in Scientific reports (10.01.2022)
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Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints
Nowosad, Karol, Brouwer, Rutger W. W., Odrzywolski, Adrian, Korporaal, Anne L., Gielniewski, Bartłomiej, Wojtaś, Bartosz, van IJcken, Wilfred F. J., Grosveld, Frank, Huylebroeck, Danny, Tylzanowski, Przemko
Published in Scientific reports (27.07.2022)
Published in Scientific reports (27.07.2022)
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CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells
Veltman, Mieke, De Sanctis, Juan B, Stolarczyk, Marta, Klymiuk, Nikolai, Bähr, Andrea, Brouwer, Rutger W, Oole, Edwin, Shah, Juhi, Ozdian, Tomas, Liao, Jie, Martini, Carolina, Radzioch, Danuta, Hanrahan, John W, Scholte, Bob J
Published in Frontiers in physiology (04.02.2021)
Published in Frontiers in physiology (04.02.2021)
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Journal Article
The tumor suppressor MIR139 is silenced by POLR2M to promote AML oncogenesis
Stavast, Christiaan J., van Zuijen, Iris, Karkoulia, Elena, Özçelik, Arman, van Hoven-Beijen, Antoinette, Leon, Leticia G., Voerman, Jane S. A., Janssen, George M. C., van Veelen, Peter A., Burocziova, Monika, Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Maas, Alex, Bindels, Eric M., van der Velden, Vincent H. J., Schliehe, Christopher, Katsikis, Peter D., Alberich-Jorda, Meritxell, Erkeland, Stefan J.
Published in Leukemia (01.03.2022)
Published in Leukemia (01.03.2022)
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Journal Article
Clinical significance of immunohistochemistry for detection of BAP1 mutations in uveal melanoma
Koopmans, Anna E, Verdijk, Robert M, Brouwer, Rutger W W, van den Bosch, Thierry P P, van den Berg, Mike M P, Vaarwater, Jolanda, Kockx, Christel E M, Paridaens, Dion, Naus, Nicole C, Nellist, Mark, van IJcken, Wilfred F J, Kiliç, Emine, de Klein, Annelies
Published in Modern pathology (01.10.2014)
Published in Modern pathology (01.10.2014)
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Journal Article
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer
Doffo, Josefina, Bamopoulos, Stefanos A, Köse, Hazal, Orben, Felix, Zang, Chuanbing, Pons, Miriam, den Dekker, Alexander T, Brouwer, Rutger W W, Baluapuri, Apoorva, Habringer, Stefan, Reichert, Maximillian, Illendula, Anuradha, Krämer, Oliver H, Schick, Markus, Wolf, Elmar, van IJcken, Wilfred F J, Esposito, Irene, Keller, Ulrich, Schneider, Günter, Wirth, Matthias
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2022)
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Journal Article
Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice
Halim, Danny, Wilson, Michael P., Oliver, Daniel, Brosens, Erwin, Verheij, Joke B. G. M., Han, Yu, Nanda, Vivek, Lyu, Qing, Doukas, Michael, Stoop, Hans, Brouwer, Rutger W. W., van IJcken, Wilfred F. J., Slivano, Orazio J., Burns, Alan J., Christie, Christine K., de Mesy Bentley, Karen L., Brooks, Alice S., Tibboel, Dick, Xu, Suowen, Jin, Zheng Gen, Djuwantono, Tono, Yan, Wei, Alves, Maria M., Hofstra, Robert M. W., Miano, Joseph M.
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2017)
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Journal Article
Targeted Next Generation Sequencing reveals previously unidentified TSC1 and TSC2 mutations
Nellist, Mark, Brouwer, Rutger W W, Kockx, Christel E M, van Veghel-Plandsoen, Monique, Withagen-Hermans, Caroline, Prins-Bakker, Lida, Hoogeveen-Westerveld, Marianne, Mrsic, Alan, van den Berg, Mike M P, Koopmans, Anna E, de Wit, Marie-Claire, Jansen, Floor E, Maat-Kievit, Anneke J A, van den Ouweland, Ans, Halley, Dicky, de Klein, Annelies, van IJcken, Wilfred F J
Published in BMC medical genetics (25.02.2015)
Published in BMC medical genetics (25.02.2015)
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Single-Cell RNA Sequencing of Donor-Reactive T Cells Reveals Role of Apoptosis in Donor-Specific Hyporesponsiveness of Kidney Transplant Recipients
van der List, Amy C. J., Litjens, Nicolle H. R., Brouwer, Rutger W. W., Klepper, Mariska, den Dekker, Alexander T., van Ijcken, Wilfred F. J., Betjes, Michiel G. H.
Published in International journal of molecular sciences (01.10.2023)
Published in International journal of molecular sciences (01.10.2023)
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Journal Article
Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome
Birkhoff, Judith C, Korporaal, Anne L, Brouwer, Rutger W W, Nowosad, Karol, Milazzo, Claudia, Mouratidou, Lidia, van den Hout, Mirjam C G N, van IJcken, Wilfred F J, Huylebroeck, Danny, Conidi, Andrea
Published in Genes (02.03.2023)
Published in Genes (02.03.2023)
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PTRHD1 Loss‐of‐function mutation in an african family with juvenile‐onset Parkinsonism and intellectual disability
Kuipers, Demy J.S., Carr, Jonathan, Bardien, Soraya, Thomas, Pearl, Sebate, Boiketlo, Breedveld, Guido J., van Minkelen, Rick, Brouwer, Rutger W.W., van Ijcken, Wilfred F.J., van Slegtenhorst, Marjon A., Bonifati, Vincenzo, Quadri, Marialuisa
Published in Movement disorders (01.11.2018)
Published in Movement disorders (01.11.2018)
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Journal Article
The relative value of operon predictions
Brouwer, Rutger W. W., Kuipers, Oscar P., van Hijum, Sacha A. F. T.
Published in Briefings in bioinformatics (01.09.2008)
Published in Briefings in bioinformatics (01.09.2008)
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The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes
Knoch, Tobias A, Wachsmuth, Malte, Kepper, Nick, Lesnussa, Michael, Abuseiris, Anis, Ali Imam, A M, Kolovos, Petros, Zuin, Jessica, Kockx, Christel E M, Brouwer, Rutger W W, van de Werken, Harmen J G, van IJcken, Wilfred F J, Wendt, Kerstin S, Grosveld, Frank G
Published in Epigenetics & chromatin (24.12.2016)
Published in Epigenetics & chromatin (24.12.2016)
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Journal Article
CRISPRs in the human genome are differentially expressed between malignant and normal adjacent to tumor tissue
van Riet, Job, Saha, Chinmoy, Strepis, Nikolaos, Brouwer, Rutger W. W., Martens-Uzunova, Elena S., van de Geer, Wesley S., Swagemakers, Sigrid M. A., Stubbs, Andrew, Halimi, Yassir, Voogd, Sanne, Tanmoy, Arif Mohammad, Komor, Malgorzata A., Hoogstrate, Youri, Janssen, Bart, Fijneman, Remond J. A., Niknafs, Yashar S., Chinnaiyan, Arul M., van IJcken, Wilfred F. J., van der Spek, Peter J., Jenster, Guido, Louwen, Rogier
Published in Communications biology (08.04.2022)
Published in Communications biology (08.04.2022)
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Effect of bovine milk fat-based infant formulae on microbiota, metabolites and stool parameters in healthy term infants in a randomized, crossover, placebo-controlled trial
Looijesteijn, Ellen, Brouwer, Rutger W. W., Schoemaker, Ruud J. W., Ulfman, Laurien H., Ham, Stephanie L., Jeurink, Prescilla, Karaglani, Eva, van IJcken, Wilfred F. J., Manios, Yannis
Published in BMC nutrition (29.08.2022)
Published in BMC nutrition (29.08.2022)
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Journal Article
Validation of a Combined Transcriptome and T Cell Receptor Alpha/Beta (TRA/TRB) Repertoire Assay at the Single Cell Level for Paucicellular Samples
Litjens, Nicolle H R, Langerak, Anton W, van der List, Amy C J, Klepper, Mariska, de Bie, Maaike, Azmani, Zakia, den Dekker, Alexander T, Brouwer, Rutger W W, Betjes, Michiel G H, Van IJcken, Wilfred F J
Published in Frontiers in immunology (28.08.2020)
Published in Frontiers in immunology (28.08.2020)
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Unraveling the Genetics of Congenital Diaphragmatic Hernia: An Ongoing Challenge
Brosens, Erwin, Peters, Nina C J, van Weelden, Kim S, Bendixen, Charlotte, Brouwer, Rutger W W, Sleutels, Frank, Bruggenwirth, Hennie T, van Ijcken, Wilfred F J, Veenma, Danielle C M, Otter, Suzan C M Cochius-Den, Wijnen, Rene M H, Eggink, Alex J, van Dooren, Marieke F, Reutter, Heiko Martin, Rottier, Robbert J, Schnater, J Marco, Tibboel, Dick, de Klein, Annelies
Published in Frontiers in pediatrics (03.02.2022)
Published in Frontiers in pediatrics (03.02.2022)
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