Evaluation of von Willebrand factor and von Willebrand factor propeptide in models of vascular endothelial cell activation, perturbation, and/or injury
Brott, David A, Katein, Anne, Thomas, Heath, Lawton, Michael, Montgomery, Robert R, Richardson, Rudy J, Louden, Calvert S
Published in Toxicologic pathology (01.06.2014)
Published in Toxicologic pathology (01.06.2014)
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Journal Article
Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes
Brott, David A, Goodman, Michael J, Hermann, Richard P, Anderson, Isobel, Kiazand, Alexandre
Published in Drug design, development and therapy (01.01.2020)
Published in Drug design, development and therapy (01.01.2020)
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Journal Article
Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes
Brott, David A, Furlong, Stephen T, Adler, Scott H, Hainer, James W, Arani, Ramin B, Pinches, Mark, Rossing, Peter, Chaturvedi, Nish
Published in Drug design, development and therapy (01.01.2015)
Published in Drug design, development and therapy (01.01.2015)
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Journal Article
An acute rat in vivo screening model to predict compounds that alter blood glucose and/or insulin regulation
Brott, David A., Diamond, Melody, Campbell, Pam, Zuvich, Andy, Cheatham, Letitia, Bentley, Patricia, Gorko, Mary Ann, Fikes, James, Saye, JoAnne
Published in Journal of pharmacological and toxicological methods (01.09.2013)
Published in Journal of pharmacological and toxicological methods (01.09.2013)
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Journal Article
Are laboratory parameter (biomarker) values similar to the healthy volunteer reference range in all patient populations?
Brott, David A, Goodman, Michael J, Hermann, Richard P, Merz, Michael, Calvo, Roser, Poorkhalkali, Nadereh, Kiazand, Alexandre
Published in Drug design, development and therapy (01.01.2018)
Published in Drug design, development and therapy (01.01.2018)
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Journal Article
Translation strategy for the qualification of drug-induced vascular injury biomarkers
Bendjama, Kaïdre, Guionaud, Silvia, Aras, Gulfidan, Arber, Nadir, Badimon, Lina, Bamberger, Uwe, Bratfalean, Dorina, Brott, David, David, Maayan, Doessegger, Lucette, Firat, Hüseyin, Gallas, Jean-François, Gautier, Jean-Charles, Hoffmann, Peter, Kraus, Sarah, Padro, Teresa, Saadoun, David, Szczesny, Piotr, Thomann, Peter, Vilahur, Gemma, Lawton, Michael, Cacoub, Patrice
Published in Toxicologic pathology (01.06.2014)
Published in Toxicologic pathology (01.06.2014)
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Journal Article
Renal biomarker changes associated with hyaline droplet nephropathy in rats are time and potentially compound dependent
Brott, David A, Bentley, Patricia, Nadella, Murali V.P, Thurman, Dale, Fikes, Jim, Cheatham, Letitia, McGrath, Frank, Luo, Wenli, Kinter, Lewis B
Published in Toxicology (Amsterdam) (07.01.2013)
Published in Toxicology (Amsterdam) (07.01.2013)
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Journal Article
A peripherally restricted P2Y12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism
Brott, David A, Andersson, Håkan A S, Stewart, Jane, Ewart, Lorna, Christoph, Greg, Harleman, Johannes, Armstrong, Duncan, Kinter, Lewis B
Published in Toxicology reports (20.11.2014)
Published in Toxicology reports (20.11.2014)
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Journal Article
Inhibition of Oestradiol-induced Prolactin Release in a Dual-Cannulated Ovariectomized Rat Model by Carmoxirole, a Peripherally Restricted Dopamine Agonist
Brott, David A., Werkheiser, Jennifer L., Campbell, Pam, Bentley, Patricia, Andersson, Håkan H. A. S., Stewart, Jane, Huby, Russell, Altekar, Maneesha, Kinter, Lewis B.
Published in Basic & clinical pharmacology & toxicology (01.12.2012)
Published in Basic & clinical pharmacology & toxicology (01.12.2012)
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Journal Article
Combining radio telemetry and automated blood sampling: A novel approach for integrative pharmacology and toxicology studies
Kamendi, Harriet W., Brott, David A., Chen, Yafei, Litwin, Dennis C., Lengel, David J., Fonck, Carlos, Bui, Khanh H., Gorko, Mary Ann, Bialecki, Russell A.
Published in Journal of pharmacological and toxicological methods (01.07.2010)
Published in Journal of pharmacological and toxicological methods (01.07.2010)
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Journal Article
A peripherally restricted P2Y 12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism
Brott, David A, Andersson, Håkan A S, Stewart, Jane, Ewart, Lorna, Christoph, Greg, Harleman, Johannes, Armstrong, Duncan, Kinter, Lewis B
Published in Toxicology reports (2014)
Published in Toxicology reports (2014)
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Journal Article
Next‐Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development
Roth, Sharin E., Avigan, Mark I., Bourdet, David, Brott, David, Church, Rachel, Dash, Ajit, Keller, Douglas, Sherratt, Philip, Watkins, Paul B., Westcott‐Baker, Lucas, Lentini, Silvia, Merz, Michael, Ramaiah, Lila, Ramaiah, Shashi K., Stanley, Ann Marie, Marcinak, John
Published in Clinical pharmacology and therapeutics (01.02.2020)
Published in Clinical pharmacology and therapeutics (01.02.2020)
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Journal Article
Are Laboratory Parameter
Anderson, Isobel, Hermann, Richard P, Kiazand, Alexandre, Goodman, Michael J, Brott, David A
Published in Drug design, development and therapy (30.06.2020)
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Published in Drug design, development and therapy (30.06.2020)
Journal Article
Current status and future perspectives of renal safety biomarkers
Pinches, Mark, Benjamin, Amanda, Furlong, Stephen, Brott, David
Published in Toxicology letters (28.08.2013)
Published in Toxicology letters (28.08.2013)
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Journal Article
Assessment of cisplatin-induced kidney injury using an integrated rodent platform
Chen, Yafei, Brott, David, Luo, Wenli, Gangl, Eric, Kamendi, Harriet, Barthlow, Herbert, Lengel, David, Fikes, James, Kinter, Lewis, Valentin, Jean-Pierre, Bialecki, Russell
Published in Toxicology and applied pharmacology (01.05.2013)
Published in Toxicology and applied pharmacology (01.05.2013)
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Journal Article
Drug-induced myocardial dysfunction - recommendations for assessment in clinical and pre-clinical studies
Ebrahimi, Ahmad, Raichlen, Joel S, Pointon, Amy, Gottfridsson, Christer, Munley, Jiefen, Hockings, Paul, Cartwright, James, Buss, Nicholas, Wikström, Johannes, Gan, Li-Ming, Whittaker, Andrew, Khalil, Ali, George, Richard T, Garkaviy, Pavlo, Brott, David
Published in Expert opinion on drug safety (03.03.2020)
Published in Expert opinion on drug safety (03.03.2020)
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Journal Article