Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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In Vitro Antiviral Activity and Single-Dose Pharmacokinetics in Humans of a Novel, Orally Bioavailable Inhibitor of Human Rhinovirus 3C Protease
PATICK, Amy K, BROTHERS, Mary A, TRAN, Jonathan Q, MALDONADO, Fausto, BINFORD, Susan, MALDONADO, Oscar, FUHRMAN, Shella, PETERSEN, Annkatrin, SMITH, George J, ZALMAN, Leora S, BURNS-NAAS, Leigh Ann
Published in Antimicrobial Agents and Chemotherapy (01.06.2005)
Published in Antimicrobial Agents and Chemotherapy (01.06.2005)
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Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
DRAGOVICH, P. S, RU ZHOU, MEADOR, J. W, PATICK, A. K, FORD, C. E, BROTHERS, M. A, BINFORD, S. L, MATTHEWS, D. A, FERRE, R. A, WORLAND, S. T, WEBBER, S. E, PRINS, T. J, KWOK, A. K, OKANO, K, FUHRMAN, S. A, ZALMAN, L. S, MALDONADO, F. C, BROWN, E. L
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
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Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors
Webber, Stephen E., Marakovits, Joseph T., Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Srinivasan, Babu, Moran, Terry, Ford, Clifford E., Brothers, Mary A., Harr, James E.V., Meador, James W., Ferre, Rose Ann, Worland, Stephen T.
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Induction in vitro of a primary human antiviral cytotoxic T cell response
Cerny, A, Fowler, P, Brothers, M A, Houghton, M, Schlicht, H J, Chisari, F V
Published in European journal of immunology (01.02.1995)
Published in European journal of immunology (01.02.1995)
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Mechanism of Cytotoxicity of Human Large Granular Lymphocytes: Relationship of the Cytotoxic Lymphocyte Protein to the Ninth Component (C9) of Human Complement
Zalman, Leora S., Brothers, Mary A., Chiu, F. John, Müller-Eberhard, Hans J.
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
Published in Proceedings of the National Academy of Sciences - PNAS (01.07.1986)
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The role of C3 fragments in endocytosis and extracellular cytotoxic reactions by polymorphonuclear leukocytes
Schreiber, Robert D., Pangburn, Michael K., Bjornson, Ann B., Brothers, Mary A., Müller-Eberhard, Hans J.
Published in Clinical immunology and immunopathology (01.05.1982)
Published in Clinical immunology and immunopathology (01.05.1982)
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