Search Results - "Broten, Theodore P." :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

by Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Rittle, Kenneth E, Gilbert, Kevin F, Steele, Thomas G, Homnick, Carl F, Freidinger, Roger M, Ransom, Rick W, Kling, Paul, Reiss, Duane, Broten, Theodore P, Schorn, Terry W, Chang, Raymond S. L, O'Malley, Stacey S, Olah, Timothy V, Ellis, Joan D, Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos
Published in Journal of medicinal chemistry (13.07.2000)

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Cyclic imides as potent and selective α-1A adrenergic receptor antagonists

Cyclic imides as potent and selective α-1A adrenergic receptor antagonists

by DIPARDO, Robert M, PATANE, Michael A, NEWTON, Randall C, PRICE, Roseann, BROTEN, Theodore P, CHANG, Raymond S. L, RANSOM, Richard W, DI SALVO, Jerry, FREIDINGER, Roger M, BOCK, Mark G
Published in Bioorganic & medicinal chemistry letters (23.07.2001)

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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability

De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability

by Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M, Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Chan, Tsing-Bao, O'Malley, Stacey S, Schorn, Terry W, Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J, Freidinger, Roger, Gluchowski, Charles
Published in Journal of medicinal chemistry (27.07.2000)

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 4. Structure−Activity Relationship in the Dihydropyrimidine Series

Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 4. Structure−Activity Relationship in the Dihydropyrimidine Series

by Wong, Wai C, Sun, Wanying, Lagu, Bharat, Tian, Dake, Marzabadi, Mohammad R, Zhang, Fengqi, Nagarathnam, Dhanapalan, Miao, Shou W, Wetzel, John M, Peng, Jian, Forray, Carlos, Chang, Raymond S. L, Chen, Tsing B, Ransom, Richard, O'Malley, Stacey, Broten, Theodore P, Kling, Paul, Vyas, Kamlesh P, Zhang, Kanyin, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety

Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety

by Murali Dhar, T. G, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Lagu, Bharat, Wong, Wai C, Chiu, George, Tyagarajan, Sriram, Miao, Shou Wu, Zhang, Fengqi, Sun, Wanying, Tian, Dake, Shen, Quanrong, Zhang, Jack, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Schorn, Terry W, Chen, Tsing Bao, O'Malley, Stacy, Ransom, Richard, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Zhang, Kanyin, Gilbert, John, Pettibone, Douglas J, Patane, Michael A, Bock, Mark G, Freidinger, Roger M, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)

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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones

Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones

by Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)

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Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension

Pharmacology of losartan, an angiotensin II receptor antagonist, in animal models of hypertension

by Siegl, P K, Kivlighn, S D, Broten, T P
Published in Journal of hypertension. Supplement (01.07.1995)

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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

by Barrow, JC, Nantermet, PG, Selnick, HG, Glass, KL, Rittle, KE, Gilbert, KF, Steele, TG, Homnick, CF, Freidinger, RM, Ransom, RW, Kling, P, Reiss, D, Broten, TP, Schorn, TW, Chang, RSL, O'Malley, SS, Olah, TV, Ellis, JD, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C
Published in Journal of medicinal chemistry (13.07.2000)

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4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A Potent and Selective α1b Adrenergic Receptor Antagonist

4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A Potent and Selective α1b Adrenergic Receptor Antagonist

by Patane, Michael A., Scott, Ann L., Broten, Theodore P., Chang, Raymond S. L., Ransom, Richard W., DiSalvo, Jerry, Forray, Carlos, Bock, Mark G.
Published in Journal of medicinal chemistry (09.04.1998)

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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones

Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones

by Nagarathnam, D, Miao, SW, Lagu, B, Chiu, G, Fang, J, Dhar, TGM, Zhang, J, Tyagarajan, S, Marzabadi, MR, Zhang, FQ, Wong, WC, Sun, WY, Tian, D, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Schorn, TW, Chen, TB, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)

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Statistical criteria for using short-term measurements as an index of 24-hour mean arterial pressure in unanesthetized unrestrained dogs

Statistical criteria for using short-term measurements as an index of 24-hour mean arterial pressure in unanesthetized unrestrained dogs

by Broten, T P, Zehr, J E, Livnat, A
Published in Life sciences (1973) (1988)

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4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)-[[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A potent and selective alpha(1b) adrenergic receptor antagonist

4-amino-2-[4-[1-(benzyloxycarbonyl)-2(S)-[[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765,314): A potent and selective alpha(1b) adrenergic receptor antagonist

by Patane, MA, Scott, AL, Broten, TP, Chang, RSL, Ransom, RW, DiSalvo, J, Forray, C, Bock, MG
Published in Journal of medicinal chemistry (09.04.1998)

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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety

by Dhar, TGM, Nagarathnam, D, Marzabadi, MR, Lagu, B, Wong, WC, Chiu, G, Tyagarajan, S, Miao, SW, Zhang, FQ, Sun, WY, Tian, D, Shen, QR, Zhang, J, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Schorn, TW, Chen, TB, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Zhang, KY, Gilbert, J, Pettibone, DJ, Patane, MA, Bock, MG, Freidinger, RM, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)

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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series

Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series

by Wong, WC, Sun, WY, Lagu, B, Tian, D, Marzabadi, MR, Zhang, FQ, Nagarathnam, D, Miao, SW, Wetzel, JM, Peng, J, Forray, C, Chang, RSL, Chen, TB, Ransom, R, O'Malley, S, Broten, TP, Kling, P, Vyas, KP, Zhang, KY, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)

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De novo design of a novel oxazolidinone analogue as a potent and selective alpha(1A) adrenergic receptor antagonist with high oral bioavailability

De novo design of a novel oxazolidinone analogue as a potent and selective alpha(1A) adrenergic receptor antagonist with high oral bioavailability

by Lagu, B, Tian, D, Jeon, Y, Li, C, Wetzel, JM, Nagarathnam, D, Shen, QR, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Chan, TB, O'Malley, SS, Schorn, TW, Rodrigues, AD, Kassahun, K, Pettibone, DJ, Freidinger, R, Gluchowski, C
Published in Journal of medicinal chemistry (27.07.2000)

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Phenylacetamides as selective α-1A adrenergic receptor antagonists

Phenylacetamides as selective α-1A adrenergic receptor antagonists

by Patane, Michael A., DiPardo, Robert M., Newton, Randall C., Price, RoseAnn P., Broten, Theodore P., Chang, Raymond S.L., Ransom, Richard W., Di Salvo, Jerry, Nagarathnam, Dhanapalan, Forray, Carlos, Gluchowski, Charles, Bock, Mark G.
Published in Bioorganic & medicinal chemistry letters (07.08.2000)

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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist

by CHAKRAVARTY, P. K, NAYLOR, E. M, SCHORN, T. W, SCHAFFER, L. W, BROTEN, T. P, SIEGL, P. K. S, PATCHETT, A. A, GREENLEE, W. J, CHEN, A, CHANG, R. S. L, TSING-BAU CHEN, FAUST, K. A, LOTTI, V. J, KIVLIGHN, S. D, GABLE, R. A, ZINGARO, G. J
Published in Journal of medicinal chemistry (25.11.1994)

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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α 1A Adrenergic Receptor Antagonist with High Oral Bioavailability

De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α 1A Adrenergic Receptor Antagonist with High Oral Bioavailability

by Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M., Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L., Broten, Theodore P., Ransom, Richard W., Chan, Tsing-Bao, O'Malley, Stacey S., Schorn, Terry W., Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J., Freidinger, Roger, Gluchowski, Charles
Published in Journal of medicinal chemistry (01.07.2000)

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In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α 1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α 1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

by Barrow, James C., Nantermet, Philippe G., Selnick, Harold G., Glass, Kristen L., Rittle, Kenneth E., Gilbert, Kevin F., Steele, Thomas G., Homnick, Carl F., Freidinger, Roger M., Ransom, Rick W., Kling, Paul, Reiss, Duane, Broten, Theodore P., Schorn, Terry W., Chang, Raymond S. L., O'Malley, Stacey S., Olah, Timothy V., Ellis, Joan D., Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos
Published in Journal of medicinal chemistry (01.07.2000)

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4-Oxospiro[benzopyran-2,4′-piperidines] as selective α1a-adrenergic receptor antagonists

4-Oxospiro[benzopyran-2,4′-piperidines] as selective α1a-adrenergic receptor antagonists

by Nerenberg, Jennie B., Erb, Jill M., Bergman, Jeffrey M., O'Malley, Stacey, Chang, Raymond S.L., Scott, Ann L., Broten, Theodore P., Bock, Mark G.
Published in Bioorganic & medicinal chemistry letters (1999)

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