Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
Aggarwal, Monika, Sommers, Joshua A, Shoemaker, Robert H, Brosh, Robert M. Jr
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
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Repeat expansions confer WRN dependence in microsatellite-unstable cancers
van Wietmarschen, Niek, Sridharan, Sriram, Nathan, William J., Tubbs, Anthony, Chan, Edmond M., Callen, Elsa, Wu, Wei, Belinky, Frida, Tripathi, Veenu, Wong, Nancy, Foster, Kyla, Noorbakhsh, Javad, Garimella, Kiran, Cruz-Migoni, Abimael, Sommers, Joshua A., Huang, Yongqing, Borah, Ashir A., Smith, Jonathan T., Kalfon, Jeremie, Kesten, Nikolas, Fugger, Kasper, Walker, Robert L., Dolzhenko, Egor, Eberle, Michael A., Hayward, Bruce E., Usdin, Karen, Freudenreich, Catherine H., Brosh, Robert M., West, Stephen C., McHugh, Peter J., Meltzer, Paul S., Bass, Adam J., Nussenzweig, André
Published in Nature (London) (08.10.2020)
Published in Nature (London) (08.10.2020)
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Journal Article
G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Estep, Katrina N., Butler, Thomas J., Ding, Jun, Brosh, Jr, Robert M
Published in Current medicinal chemistry (01.01.2019)
Published in Current medicinal chemistry (01.01.2019)
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Journal Article
G-quadruplexes and helicases
Mendoza, Oscar, Bourdoncle, Anne, Boulé, Jean-Baptiste, Brosh, Jr, Robert M, Mergny, Jean-Louis
Published in Nucleic acids research (18.03.2016)
Published in Nucleic acids research (18.03.2016)
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Journal Article
A Long Noncoding RNA Regulates Sister Chromatid Cohesion
Marchese, Francesco P., Grossi, Elena, Marín-Béjar, Oskar, Bharti, Sanjay Kumar, Raimondi, Ivan, González, Jovanna, Martínez-Herrera, Dannys Jorge, Athie, Alejandro, Amadoz, Alicia, Brosh, Robert M., Huarte, Maite
Published in Molecular cell (04.08.2016)
Published in Molecular cell (04.08.2016)
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Journal Article
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)
Sommers, Joshua A, Kulikowicz, Tomasz, Croteau, Deborah L, Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Bohr, Vilhelm A, Brosh, Jr, Robert M
Published in PloS one (09.01.2019)
Published in PloS one (09.01.2019)
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DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase
Bharti, Sanjay Kumar, Sommers, Joshua A., Zhou, Jun, Kaplan, Daniel L., Spelbrink, Johannes N., Mergny, Jean-Louis, Brosh, Robert M.
Published in The Journal of biological chemistry (24.10.2014)
Published in The Journal of biological chemistry (24.10.2014)
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Journal Article
Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions
Sommers, Joshua A., Loftus, Lorin N., Jones, Martin P., Lee, Rebecca A., Haren, Caitlin E., Dumm, Adaira J., Brosh, Robert M.
Published in The Journal of biological chemistry (01.03.2023)
Published in The Journal of biological chemistry (01.03.2023)
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Journal Article
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Published in Nature communications (12.11.2021)
Published in Nature communications (12.11.2021)
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Journal Article
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome
Bharti, Sanjay Kumar, Khan, Irfan, Banerjee, Taraswi, Sommers, Joshua A, Wu, Yuliang, Brosh, Robert M., Jr
Published in Cellular and molecular life sciences : CMLS (01.07.2014)
Published in Cellular and molecular life sciences : CMLS (01.07.2014)
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