Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
Houl, Jerry H, Ye, Zu, Brosey, Chris A, Balapiti-Modarage, Lakshitha P F, Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L, Pourfarjam, Yasin, Warden, Leslie S, Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A, Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D, Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E, Ahmed, Zamal, Tainer, John A
Published in Nature communications (11.12.2019)
Published in Nature communications (11.12.2019)
Get full text
Journal Article
A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase
Kim, In-Kwon, Stegeman, Roderick A., Brosey, Chris A., Ellenberger, Tom
Published in The Journal of biological chemistry (06.02.2015)
Published in The Journal of biological chemistry (06.02.2015)
Get full text
Journal Article
Functional Dynamics in Replication Protein A DNA Binding and Protein Recruitment Domains
Brosey, Chris A., Soss, Sarah E., Brooks, Sonja, Yan, Chunli, Ivanov, Ivaylo, Dorai, Kavita, Chazin, Walter J.
Published in Structure (London) (02.06.2015)
Published in Structure (London) (02.06.2015)
Get full text
Journal Article
Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.
Published in Progress in biophysics and molecular biology (01.08.2021)
Published in Progress in biophysics and molecular biology (01.08.2021)
Get full text
Journal Article
Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Brosey, Chris A, Link, Todd M, Shen, Runze, Moiani, Davide, Burnett, Kathryn, Hura, Greg L, Jones, Darin E, Tainer, John A
Published in Nature chemical biology (26.04.2024)
Published in Nature chemical biology (26.04.2024)
Get full text
Journal Article
Applying HT-SAXS to chemical ligand screening
Brosey, Chris A, Shen, Runze, Moiani, Davide, Jones, Darin E, Burnett, Kathryn, Hura, Greg L, Tainer, John A
Published in Methods in enzymology (01.01.2023)
Published in Methods in enzymology (01.01.2023)
Get more information
Journal Article
A new structural framework for integrating replication protein A into DNA processing machinery
Brosey, Chris A, Yan, Chunli, Tsutakawa, Susan E, Heller, William T, Rambo, Robert P, Tainer, John A, Ivanov, Ivaylo, Chazin, Walter J
Published in Nucleic acids research (01.02.2013)
Published in Nucleic acids research (01.02.2013)
Get full text
Journal Article
Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities
Moiani, Davide, Ronato, Daryl A, Brosey, Chris A, Arvai, Andrew S, Syed, Aleem, Masson, Jean-Yves, Petricci, Elena, Tainer, John A
Published in Methods in enzymology (2018)
Published in Methods in enzymology (2018)
Get more information
Journal Article
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2
Moiani, Davide, Link, Todd M, Brosey, Chris A, Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E, Tsutakawa, Susan E, Tainer, John A
Published in Methods in enzymology (2021)
Published in Methods in enzymology (2021)
Get more information
Journal Article
Structural Dynamics and Single-Stranded DNA Binding Activity of the Three N-Terminal Domains of the Large Subunit of Replication Protein A from Small Angle X-ray Scattering
Pretto, Dalyir I, Tsutakawa, Susan, Brosey, Chris A, Castillo, Amalchi, Chagot, Marie-Eve, Smith, Jarrod A, Tainer, John A, Chazin, Walter J
Published in Biochemistry (Easton) (06.04.2010)
Published in Biochemistry (Easton) (06.04.2010)
Get full text
Journal Article
Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF
Published in Nature chemical biology
(06.05.2024)
Get full text
Journal Article
Apoptosis-inducing factor: mechanistic insights and therapeutic opportunities from a metabolic allosteric switch
Brosey, Chris A., Shen, Runze, Burnett, Kathryn, Hura, Greg, Tainer, John A.
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2019)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2019)
Get full text
Journal Article
Shape shifting in apoptosis-inducing factor allostery and interactions: switching between oxidative phosphorylation and cell death
Brosey, Chris A., Shen, Runze, Burnett, Kathryn, Hura, Greg L., Tainer, John A.
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2018)
Get full text
Journal Article