Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase
BERGE, JOHN M., BROOM, NIGEL J. P., HOUGE-FRYDRYCH, CATHERINE S. V., JARVEST, RICHARD L., MENSAH, LUCY, MCNAIR, DAVID J., O'HANLON, PETER J., POPE, ANDREW J., RITTENHOUSE, STEPHEN
Published in Journal of antibiotics (01.11.2000)
Published in Journal of antibiotics (01.11.2000)
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Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A
Brown, Murray J. B, Mensah, Lucy M, Doyle, Michael L, Broom, Nigel J. P, Osbourne, Neal, Forrest, Andrew K, Richardson, Christine M, O'Hanlon, Peter J, Pope, Andrew J
Published in Biochemistry (Easton) (23.05.2000)
Published in Biochemistry (Easton) (23.05.2000)
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The Chemistry of Pseudomonic Acid. † 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity
Brown, Pamela, Best, Desmond J, Broom, Nigel J. P, Cassels, Robert, O'Hanlon, Peter J, Mitchell, Timothy J, Osborne, Neal F, Wilson, Jennifer M
Published in Journal of medicinal chemistry (01.08.1997)
Published in Journal of medicinal chemistry (01.08.1997)
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Chemistry of Pseudomonic Acid. Part 16: Aryl and Heteroaryl Ketone Derivatives of Monic Acid
ABSON, ANGELA, BROOM, NIGEL J. P., COATES, PHILIPPA A., ELDER, JOHN S., FORREST, ANDREW K., HANNAN, PETER C. T., HICKS, AMANDA J., O'HANLON, PETER J., MASSON, NICKY D., PEARSON, NEIL D., PONS, JEAN E., WILSON, JENNIFER M.
Published in Journal of antibiotics (1996)
Published in Journal of antibiotics (1996)
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The Chemistry of Pseudomonic Acid. 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity
Broom, Nigel J. P, Cassels, Robert, Cheng, Hung-Yuan, Elder, John S, Hannan, Peter C. T, Masson, Nicki, O'Hanlon, Peter J, Pope, Andrew, Wilson, Jennifer M
Published in Journal of medicinal chemistry (30.08.1996)
Published in Journal of medicinal chemistry (30.08.1996)
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6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD SPECTRUM INHIBITORS OF BACTERIAL β-LACTAMASE: V. CHIRAL 1, 2, 3-TRIAZOLYL DERIVATIVES
BENNETT, ISABEL S., BROOKS, GERALD, BROOM, NIGEL J. P., CALVERT, STEPHEN H., COLEMAN, KENNETH, FRANÇOIS, IRENE
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD SPECTRUM INHIBITORS OF BACTERIAL β-LACTAMASE: IV. KIDNEY STABILITY, SERUM BINDING AND ADDITIONAL BIOLOGICAL EVALUATION OF RACEMIC DERIVATIVES
BENNETT, ISABEL S., BROOM, NIGEL J. P., COLEMAN, KENNETH, COULTON, STEVEN, EDWARDS, PETER D., FRANCOIS, IRENE, GRIFFIN, DAVID R. J., OSBORNE, NEAL F., WOODALL, PAMELA M.
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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SYNTHESIS OF (5R)-(Z)-6-(1-METHYL-1,2,3-TRIAZOL-4-YLMETHYLENE)PENEM-3-CARBOXYLIC ACID, A POTENT BROAD-SPECTRUM BETA-LACTAMASE INHIBITOR, FROM 6-AMINOPENICILLANIC ACID
OSBORNE, NF, ATKINS, RJ, BROOM, NJP, COULTON, S, HARBRIDGE, JB, HARRIS, MA, STIRLINGFRANCOIS, WALKER, G
Published in J. Chem. Soc., Perkin Trans. 1 (1994)
Published in J. Chem. Soc., Perkin Trans. 1 (1994)
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A new route to 4-hydroxytetralones and 1-naphthols
Broom, Nigel J. P., Sammes, Peter G.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1981)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1981)
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STUDIES ON THE MECHANISM OF ACTION OF (5R)-(Z)-6-(1-METHYL-1,2,3-TRIAZOL-4-YLMETHYLENE)PENEM-3-CARBOXYLIC ACID (BRL-42715), A POTENT INHIBITOR OF BACTERIAL BETA-LACTAMASE
BROOM, NJP, FARMER, TH, OSBORNE, NF, TYLER, JW
Published in Journal of the Chemical Society. Chemical communications (1992)
Published in Journal of the Chemical Society. Chemical communications (1992)
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A general route to substituted naphthols
Broom, Nigel J. P., Sammes, Peter G.
Published in Journal of the Chemical Society. Chemical communications (1978)
Published in Journal of the Chemical Society. Chemical communications (1978)
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A NOVEL AND STEREOCONTROLLED SYNTHESIS OF (5R)-(Z)-6-(1-METHYL-1,2,3-TRIAZOL-4-YLMETHYLENE)PENEM-3-CARBOXYLIC ACID, A POTENT BROAD-SPECTRUM BETA-LACTAMASE INHIBITOR
OSBORNE, NF, BROOM, NJP, COULTON, S, HARBRIDGE, JB, HARRIS, MA, STIRLINGFRANCOIS, WALKER, G
Published in Journal of the Chemical Society. Chemical communications (1989)
Published in Journal of the Chemical Society. Chemical communications (1989)
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