Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ
Allen, Rodger A, Brookings, Daniel C, Powell, Mark J, Delgado, Jean, Shuttleworth, Lindsay K, Merriman, Mark, Fahy, Ian J, Tewari, Roohi, Silva, John P, Healy, Louise J, Davies, Gareth C G, Twomey, Breda, Cutler, Rona M, Kotian, Apoorva, Crosby, Andrea, McCluskey, Gillian, Watt, Gillian F, Payne, Andrew
Published in The Journal of pharmacology and experimental therapeutics (01.06.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2017)
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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis
Vugler, Alexander, O’Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Brookings, Daniel, Horsley, Helen, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter
Published in Frontiers in pharmacology (16.11.2022)
Published in Frontiers in pharmacology (16.11.2022)
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Journal Article
Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting
Meier, Christoph, Brookings, Daniel C., Ceska, Thomas A., Doyle, Carl, Gong, Haiping, McMillan, David, Saville, Giles P., Mushtaq, Adeel, Knight, David, Reich, Stefanie, Pearl, Laurence H., Powell, Keith A., Savva, Renos, Allen, Rodger A.
Published in Journal of structural biology (01.02.2012)
Published in Journal of structural biology (01.02.2012)
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Journal Article
Fused thiophene derivatives as MEK inhibitors
Laing, Victoria E., Brookings, Daniel C., Carbery, Rachel J., Simorte, Jose Gascon, Hutchings, Martin C., Langham, Barry J., Lowe, Martin A., Allen, Rodger A., Fetterman, Joanne R., Turner, James, Meier, Christoph, Kennedy, Jeff, Merriman, Mark
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Peptide deformylase inhibitors with activity against respiratory tract pathogens
East, Stephen P, Beckett, R.Paul, Brookings, Daniel C, Clements, John M, Doel, Sheila, Keavey, Kenneth, Pain, Gilles, Smith, Helen K, Thomas, Wayne, Thompson, Alison J, Todd, Richard S, Whittaker, Mark
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
Published in Bioorganic & medicinal chemistry letters (05.01.2004)
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Journal Article
Asymmetric ethylmagnesiation of alkenes using a novel zirconium catalyst
Bell, Louise, Brookings, Daniel C, Dawson, Graham J, Whitby, Richard J, Jones, Raymond V.H, Standen, Michael C.H
Published in Tetrahedron (26.11.1998)
Published in Tetrahedron (26.11.1998)
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Journal Article
Induction of Planar Chirality in Formation of (η5:η1-1-(1-Cyclohexyl-2-(diphenylphosphino)ethyl)indenyl)carbonylrhodium and (η5:η1-1-(2-Phenyl-2- (diphenylphosphino)ethyl)indenyl)carbonylrhodium
Brookings, Daniel C, Harrison, Stephen A, Whitby, Richard J, Crombie, Barry, Jones, Ray V. H
Published in Organometallics (29.10.2001)
Published in Organometallics (29.10.2001)
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Journal Article
Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors
Holdsworth, Gill, Slocombe, Patrick, Doyle, Carl, Sweeney, Bernadette, Veverka, Vaclav, Le Riche, Kelly, Franklin, Richard J., Compson, Joanne, Brookings, Daniel, Turner, James, Kennedy, Jeffery, Garlish, Rachael, Shi, Jiye, Newnham, Laura, McMillan, David, Muzylak, Mariusz, Carr, Mark D., Henry, Alistair J., Ceska, Thomas, Robinson, Martyn K.
Published in The Journal of biological chemistry (03.08.2012)
Published in The Journal of biological chemistry (03.08.2012)
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Journal Article
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo
Reuberson, James, Horsley, Helen, Franklin, Richard J, Ford, Daniel, Neuss, Judi, Brookings, Daniel, Huang, Qiuya, Vanderhoydonck, Bart, Gao, Ling-Jie, Jang, Mi-Yeon, Herdewijn, Piet, Ghawalkar, Anant, Fallah-Arani, Farnaz, Khan, Adnan R, Henshall, Jamie, Jairaj, Mark, Malcolm, Sarah, Ward, Eleanor, Shuttleworth, Lindsay, Lin, Yuan, Li, Shengqiao, Louat, Thierry, Waer, Mark, Herman, Jean, Payne, Andrew, Ceska, Tom, Doyle, Carl, Pitt, Will, Calmiano, Mark, Augustin, Martin, Steinbacher, Stefan, Lammens, Alfred, Allen, Rodger
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
TNF 활성의 조절인자로서의 융합된 펜타사이클릭 이미다졸 유도체
HORSLEY HELEN TRACEY, BROOKINGS DANIEL CHRISTOPHER, FORICHER YANN, MACCOSS MALCOLM, XUAN MENGYANG, JOHNSON JAMES ANDREW, HUTCHINGS MARTIN CLIVE, DE HARO GARCIA TERESA, ZHU ZHAONING
Year of Publication 23.12.2019
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Year of Publication 23.12.2019
Patent
4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase
Alexander, Rikki, Balasundaram, Ahrani, Batchelor, Mark, Brookings, Daniel, Crépy, Karen, Crabbe, Tom, Deltent, Marie-France, Driessens, Frank, Gill, Andrew, Harris, Sue, Hutchinson, Gillian, Kulisa, Claire, Merriman, Mark, Mistry, Prakash, Parton, Ted, Turner, James, Whitcombe, Ian, Wright, Sara
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Novel nucleotide triphosphates as potent P2Y2 agonists
BROOKINGS, Daniel, DAVENPORT, Richard J, DAVIS, Jeremy, GALVIN, Frances C. A, LLOYD, Steve, MACK, Stephen R, OWENS, Ray, SABIN, Verity, WYNN, Joanne
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Journal Article
FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES
FILOCHE ROMME BRUNO, JADOT SOPHIE, BROOKINGS DANIEL CHRISTOPHER, FORICHER YANN, SELBY MATTHEW DUNCAN, DE HARO GARCIA TERESA, KEYAERTS JEAN, DELIGNY MICHAEL, ZHU ZHAONING, SWINNEN DOMINIQUE LOUIS LEON, XUAN MENGYANG, CALMIANO MARK DANIEL, SHAW MICHAEL ALAN, JOHNSON JAMES ANDREW, HUTCHINGS MARTIN CLIVE, HEER JAG PAUL, QUINCEY JOANNA RACHEL, EVRARD YVES, MAC COSS MALCOLM, SCHIO LAURENT
Year of Publication 19.06.2017
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Year of Publication 19.06.2017
Patent
QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS
FRANKLIN RICHARD JEREMY, BROOKINGS DANIEL CHRISTOPHER, BROWN JULIEN ALISTAIR, PARTON ANDREW HARRY, LANGHAM BARRY JOHN, FORD DANIEL JAMES, ALI MEZHER HUSSEIN, QUINCEY JOANNA RACHEL, NEUSS JUDI CHARLOTTE
Year of Publication 23.12.2013
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Year of Publication 23.12.2013
Patent