Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model
Handratta, Venkatesh D, Vasaitis, Tadas S, Njar, Vincent C. O, Gediya, Lalji K, Kataria, Ritesh, Chopra, Pankaj, Newman, Donnell, Farquhar, Rena, Guo, Zhiyong, Qiu, Yun, Brodie, Angela M. H
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
JELOVAC, Danijela, SABNIS, Gauri, LONG, Brian J, MACEDO, Luciana, GOLOUBEVA, Olga G, BRODIE, Angela M. H
Published in Cancer research (Chicago, Ill.) (15.06.2005)
Published in Cancer research (Chicago, Ill.) (15.06.2005)
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Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model
JELOVAC, Danijela, MACEDO, Luciana, GOLOUBEVA, Olga G, HANDRATTA, Venkatesh, BRODIE, Angela M. H
Published in Cancer research (Chicago, Ill.) (15.06.2005)
Published in Cancer research (Chicago, Ill.) (15.06.2005)
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Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR
Schayowitz, A, Sabnis, G, Goloubeva, O, Njar, V C O, Brodie, A M H
Published in British journal of cancer (28.09.2010)
Published in British journal of cancer (28.09.2010)
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The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts
Samsel, Leigh, Zaidel, Grazyna, Drumgoole, Honesty M., Jelovac, Danijela, Drachenberg, Cinthia, Rhee, Juong G., Brodie, Angela M.H., Bielawska, Alicja, Smyth, Miriam J.
Published in The Prostate (01.03.2004)
Published in The Prostate (01.03.2004)
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Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C-17,C-20-lyase (P450(17 alpha)): Potential agents for the treatment of prostate cancer
Njar, VCO, Kato, K, Nnane, IP, Grigoryev, DN, Long, BJ, Brodie, AMH
Published in Journal of medicinal chemistry (12.03.1998)
Published in Journal of medicinal chemistry (12.03.1998)
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Journal Article
Three Dimensional Pharmacophore Modeling of Human CYP17 Inhibitors. Potential Agents for Prostate Cancer Therapy
Clement, Omoshile O, Freeman, Clive M, Hartmann, Rolf W, Handratta, Venkatesh D, Vasaitis, Tadas S, Brodie, Angela M. H, Njar, Vincent C. O
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
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Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice
Patel, Jyoti B, Huynh, Carlic K, Handratta, Venkatesh D, Gediya, Lalji K, Brodie, Angela M. H, Goloubeva, Olga G, Clement, Omoshile O, Nanne, Ivo P, Soprano, Dianne Robert, Njar, Vincent C. O
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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Aromatase and COX-2 expression in human breast cancers
Brodie, A.M.H, Lu, Q, Long, B.J, Fulton, A, Chen, T, Macpherson, N, DeJong, P.C, Blankenstein, M.A, Nortier, J.W.R, Slee, P.H.T.J, van de Ven, J, van Gorp, J.M.H.H, Elbers, J.R.J, Schipper, M.E.I, Blijham, G.H, Thijssen, J.H
Published in Journal of steroid biochemistry and molecular biology (01.12.2001)
Published in Journal of steroid biochemistry and molecular biology (01.12.2001)
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Conference Proceeding
Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors
Bhatnagar, A.S, Brodie, A.M.H, Long, B.J, Evans, D.B, Miller, W.R
Published in Journal of steroid biochemistry and molecular biology (01.01.2001)
Published in Journal of steroid biochemistry and molecular biology (01.01.2001)
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Journal Article
Conference Proceeding
Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications
Brodie, Angela M.H, Njar, Vincent C.O
Published in Journal of Steroid Biochemistry and Molecular Biology (01.07.1998)
Published in Journal of Steroid Biochemistry and Molecular Biology (01.07.1998)
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Book Review
Journal Article
Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model
Handratta, Venkatesh D., Jelovac, Danijela, Long, Brian J., Kataria, Ritesh, Nnane, Ivo P., Njar, Vincent C.O., Brodie, Angela M.H.
Published in The Journal of steroid biochemistry and molecular biology (01.10.2004)
Published in The Journal of steroid biochemistry and molecular biology (01.10.2004)
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