The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies
Yang, Hao, McDaniel, Elizabeth C, Impano, Stella, Byer, Amanda S, Jodts, Richard J, Yokoyama, Kenichi, Broderick, William E, Broderick, Joan B, Hoffman, Brian M
Published in Journal of the American Chemical Society (31.07.2019)
Published in Journal of the American Chemical Society (31.07.2019)
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Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme
Vey, Jessica L, Yang, Jian, Li, Meng, Broderick, William E, Broderick, Joan B, Drennan, Catherine L
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2008)
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HydF as a scaffold protein in [FeFe] hydrogenase H-cluster biosynthesis
McGlynn, Shawn E., Shepard, Eric M., Winslow, Mark A., Naumov, Anatoli V., Duschene, Kaitlin S., Posewitz, Matthew C., Broderick, William E., Broderick, Joan B., Peters, John W.
Published in FEBS letters (25.06.2008)
Published in FEBS letters (25.06.2008)
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Mechanism of Radical Initiation in the Radical S‑Adenosyl‑l‑methionine Superfamily
Broderick, William E, Hoffman, Brian M, Broderick, Joan B
Published in Accounts of chemical research (20.11.2018)
Published in Accounts of chemical research (20.11.2018)
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Journal Article
Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily
Hoffman, Brian M, Broderick, William E, Broderick, Joan B
Published in Annual review of biochemistry (20.06.2023)
Published in Annual review of biochemistry (20.06.2023)
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Radical SAM enzymes: surprises along the path to understanding mechanism
Broderick, William E., Broderick, Joan B.
Published in Journal of biological inorganic chemistry (01.09.2019)
Published in Journal of biological inorganic chemistry (01.09.2019)
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Journal Article
Spectroscopic Approaches to Elucidating Novel Iron−Sulfur Chemistry in the “Radical-SAM” Protein Superfamily
Walsby, Charles J, Ortillo, Danilo, Yang, Jian, Nnyepi, Mbako R, Broderick, William E, Hoffman, Brian M, Broderick, Joan B
Published in Inorganic chemistry (21.02.2005)
Published in Inorganic chemistry (21.02.2005)
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Journal Article
Radical SAM catalysis via an organometallic intermediate with an Fe–[5′-C]-deoxyadenosyl bond
Horitani, Masaki, Shisler, Krista, Broderick, William E., Hutcheson, Rachel U., Duschene, Kaitlin S., Marts, Amy R., Hoffman, Brian M., Broderick, Joan B.
Published in Science (American Association for the Advancement of Science) (13.05.2016)
Published in Science (American Association for the Advancement of Science) (13.05.2016)
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Journal Article
Pyruvate formate-lyase activating enzyme: The catalytically active 5'-deoxyadenosyl radical caught in the act of H-atom abstraction
Lundahl, Maike N, Yang, Hao, Broderick, William E, Hoffman, Brian M, Broderick, Joan B
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2023)
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Journal Article
[FeFe]‐Hydrogenase In Vitro Maturation
Pagnier, Adrien, Balci, Batuhan, Shepard, Eric M., Broderick, William E., Broderick, Joan B.
Published in Angewandte Chemie (International ed.) (05.12.2022)
Published in Angewandte Chemie (International ed.) (05.12.2022)
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Semisynthetic maturation of [FeFe]-hydrogenase using [Fe(μ-SH)(CN)(CO)]: key roles for HydF and GTP
Balci, Batuhan, O'Neill, Roark D, Shepard, Eric M, Pagnier, Adrien, Marlott, Alexander, Mock, Michael T, Broderick, William E, Broderick, Joan B
Published in Chemical communications (Cambridge, England) (18.07.2023)
Published in Chemical communications (Cambridge, England) (18.07.2023)
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Role of ammonia-lyases in the synthesis of the dithiomethylamine ligand during [FeFe]-hydrogenase maturation
Pagnier, Adrien, Balci, Batuhan, Shepard, Eric M., Yang, Hao, Drena, Alex, Holliday, Gemma L., Hoffman, Brian M., Broderick, William E., Broderick, Joan B.
Published in The Journal of biological chemistry (01.10.2024)
Published in The Journal of biological chemistry (01.10.2024)
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Journal Article
Direct Detection of the α‑Carbon Radical Intermediate Formed by OspD: Mechanistic Insights into Radical S‑Adenosyl‑l‑methionine Peptide Epimerization
Walls, William G., Vagstad, Anna L., Delridge, Tyler, Piel, Jörn, Broderick, William E., Broderick, Joan B.
Published in Journal of the American Chemical Society (28.02.2024)
Published in Journal of the American Chemical Society (28.02.2024)
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ENDOR Spectroscopy Reveals the “Free” 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe–4S]2+ Cluster
Yang, Hao, Ho, Madeline B., Lundahl, Maike N., Mosquera, Martín A., Broderick, William E., Broderick, Joan B., Hoffman, Brian M.
Published in Journal of the American Chemical Society (14.02.2024)
Published in Journal of the American Chemical Society (14.02.2024)
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Journal Article
S -Adenosyl-l-ethionine is a Catalytically Competent Analog of S -Adenosyl-l-methione (SAM) in the Radical SAM Enzyme HydG
Impano, Stella, Yang, Hao, Shepard, Eric M, Swimley, Ryan, Pagnier, Adrien, Broderick, William E, Hoffman, Brian M, Broderick, Joan B
Published in Angewandte Chemie International Edition (23.02.2021)
Published in Angewandte Chemie International Edition (23.02.2021)
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Journal Article
Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S‑Adenosylmethionine Derived Methyl Radical
Yang, Hao, Impano, Stella, Shepard, Eric M, James, Christopher D, Broderick, William E, Broderick, Joan B, Hoffman, Brian M
Published in Journal of the American Chemical Society (09.10.2019)
Published in Journal of the American Chemical Society (09.10.2019)
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Examining Pathways of Iron and Sulfur Acquisition, Trafficking, Deployment, and Storage in Mineral-Grown Methanogen Cells
Payne, Devon, Shepard, Eric M, Spietz, Rachel L, Steward, Katherine, Brumfield, Sue, Young, Mark, Bothner, Brian, Broderick, William E, Broderick, Joan B, Boyd, Eric S
Published in Journal of bacteriology (08.09.2021)
Published in Journal of bacteriology (08.09.2021)
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Journal Article
S‐Adenosyl‐l‐ethionine is a Catalytically Competent Analog of S‐Adenosyl‐l‐methionine (SAM) in the Radical SAM Enzyme HydG
Impano, Stella, Yang, Hao, Shepard, Eric M., Swimley, Ryan, Pagnier, Adrien, Broderick, William E., Hoffman, Brian M., Broderick, Joan B.
Published in Angewandte Chemie (International ed.) (23.02.2021)
Published in Angewandte Chemie (International ed.) (23.02.2021)
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Journal Article
Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage
Moody, James D., Hill, Sarah, Lundahl, Maike N., Saxton, Aubrianna J., Galambas, Amanda, Broderick, William E., Lawrence, C. Martin, Broderick, Joan B.
Published in The Journal of biological chemistry (01.06.2023)
Published in The Journal of biological chemistry (01.06.2023)
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