Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
Bido, Simone, Muggeo, Sharon, Massimino, Luca, Marzi, Matteo Jacopo, Giannelli, Serena Gea, Melacini, Elena, Nannoni, Melania, Gambarè, Diana, Bellini, Edoardo, Ordazzo, Gabriele, Rossi, Greta, Maffezzini, Camilla, Iannelli, Angelo, Luoni, Mirko, Bacigaluppi, Marco, Gregori, Silvia, Nicassio, Francesco, Broccoli, Vania
Published in Nature communications (29.10.2021)
Published in Nature communications (29.10.2021)
Get full text
Journal Article
dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice
Colasante, Gaia, Lignani, Gabriele, Brusco, Simone, Di Berardino, Claudia, Carpenter, Jenna, Giannelli, Serena, Valassina, Nicholas, Bido, Simone, Ricci, Raffaele, Castoldi, Valerio, Marenna, Silvia, Church, Timothy, Massimino, Luca, Morabito, Giuseppe, Benfenati, Fabio, Schorge, Stephanie, Leocani, Letizia, Kullmann, Dimitri M., Broccoli, Vania
Published in Molecular therapy (08.01.2020)
Published in Molecular therapy (08.01.2020)
Get full text
Journal Article
Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
Valassina, Nicholas, Brusco, Simone, Salamone, Alessia, Serra, Linda, Luoni, Mirko, Giannelli, Serena, Bido, Simone, Massimino, Luca, Ungaro, Federica, Mazzara, Pietro Giuseppe, D’Adamo, Patrizia, Lignani, Gabriele, Broccoli, Vania, Colasante, Gaia
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
Get full text
Journal Article
Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
Mazzara, Pietro Giuseppe, Muggeo, Sharon, Luoni, Mirko, Massimino, Luca, Zaghi, Mattia, Valverde, Parisa Tajalli-Tehrani, Brusco, Simone, Marzi, Matteo Jacopo, Palma, Cecilia, Colasante, Gaia, Iannielli, Angelo, Paulis, Marianna, Cordiglieri, Chiara, Giannelli, Serena Gea, Podini, Paola, Gellera, Cinzia, Taroni, Franco, Nicassio, Francesco, Rasponi, Marco, Broccoli, Vania
Published in Nature communications (21.08.2020)
Published in Nature communications (21.08.2020)
Get full text
Journal Article
Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery
Giannelli, Serena G, Luoni, Mirko, Castoldi, Valerio, Massimino, Luca, Cabassi, Tommaso, Angeloni, Debora, Demontis, Gian Carlo, Leocani, Letizia, Andreazzoli, Massimiliano, Broccoli, Vania
Published in Human molecular genetics (01.03.2018)
Published in Human molecular genetics (01.03.2018)
Get full text
Journal Article
SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring
Sessa, Alessandro, Fagnocchi, Luca, Mastrototaro, Giuseppina, Massimino, Luca, Zaghi, Mattia, Indrigo, Marzia, Cattaneo, Stefano, Martini, Davide, Gabellini, Chiara, Pucci, Cecilia, Fasciani, Alessandra, Belli, Romina, Taverna, Stefano, Andreazzoli, Massimiliano, Zippo, Alessio, Broccoli, Vania
Published in Neuron (Cambridge, Mass.) (23.10.2019)
Published in Neuron (Cambridge, Mass.) (23.10.2019)
Get full text
Journal Article
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Caiazzo, Massimiliano, Dell’Anno, Maria Teresa, Dvoretskova, Elena, Lazarevic, Dejan, Taverna, Stefano, Leo, Damiana, Sotnikova, Tatyana D., Menegon, Andrea, Roncaglia, Paola, Colciago, Giorgia, Russo, Giovanni, Carninci, Piero, Pezzoli, Gianni, Gainetdinov, Raul R., Gustincich, Stefano, Dityatev, Alexander, Broccoli, Vania
Published in Nature (London) (11.08.2011)
Published in Nature (London) (11.08.2011)
Get full text
Journal Article
Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models
Iannielli, Angelo, Bido, Simone, Folladori, Lucrezia, Segnali, Alice, Cancellieri, Cinzia, Maresca, Alessandra, Massimino, Luca, Rubio, Alicia, Morabito, Giuseppe, Caporali, Leonardo, Tagliavini, Francesca, Musumeci, Olimpia, Gregato, Giuliana, Bezard, Erwan, Carelli, Valerio, Tiranti, Valeria, Broccoli, Vania
Published in Cell reports (Cambridge) (20.02.2018)
Published in Cell reports (Cambridge) (20.02.2018)
Get full text
Journal Article
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
Banfi, Federica, Rubio, Alicia, Zaghi, Mattia, Massimino, Luca, Fagnocchi, Giulia, Bellini, Edoardo, Luoni, Mirko, Cancellieri, Cinzia, Bagliani, Anna, Di Resta, Chiara, Maffezzini, Camilla, Ianielli, Angelo, Ferrari, Maurizio, Piazza, Rocco, Mologni, Luca, Broccoli, Vania, Sessa, Alessandro
Published in Nature communications (30.06.2021)
Published in Nature communications (30.06.2021)
Get full text
Journal Article
PRRT2 controls neuronal excitability by negatively modulating Na+ channel 1.2/1.6 activity
Fruscione, Floriana, Valente, Pierluigi, Sterlini, Bruno, Romei, Alessandra, Baldassari, Simona, Fadda, Manuela, Prestigio, Cosimo, Giansante, Giorgia, Sartorelli, Jacopo, Rossi, Pia, Rubio, Alicia, Gambardella, Antonio, Nieus, Thierry, Broccoli, Vania, Fassio, Anna, Baldelli, Pietro, Corradi, Anna, Zara, Federico, Benfenati, Fabio
Published in Brain (London, England : 1878) (01.04.2018)
Published in Brain (London, England : 1878) (01.04.2018)
Get full text
Journal Article
Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome
Luoni, Mirko, Giannelli, Serena, Indrigo, Marzia Tina, Niro, Antonio, Massimino, Luca, Iannielli, Angelo, Passeri, Laura, Russo, Fabio, Morabito, Giuseppe, Calamita, Piera, Gregori, Silvia, Deverman, Benjamin, Broccoli, Vania
Published in eLife (24.03.2020)
Published in eLife (24.03.2020)
Get full text
Journal Article
The Tbr2 Molecular Network Controls Cortical Neuronal Differentiation Through Complementary Genetic and Epigenetic Pathways
Sessa, Alessandro, Ciabatti, Ernesto, Drechsel, Daniela, Massimino, Luca, Colasante, Gaia, Giannelli, Serena, Satoh, Takashi, Akira, Shizuo, Guillemot, Francois, Broccoli, Vania
Published in Cerebral cortex (New York, N.Y. 1991) (01.06.2017)
Published in Cerebral cortex (New York, N.Y. 1991) (01.06.2017)
Get full text
Journal Article
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
Wernig, Marius, Zhao, Jian-Ping, Pruszak, Jan, Hedlund, Eva, Fu, Dongdong, Soldner, Frank, Broccoli, Vania, Constantine-Paton, Martha, Isacson, Ole, Jaenisch, Rudolf
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2008)
Get full text
Journal Article
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons
Ricciardi, Sara, Ungaro, Federica, Hambrock, Melanie, Rademacher, Nils, Stefanelli, Gilda, Brambilla, Dario, Sessa, Alessandro, Magagnotti, Cinzia, Bachi, Angela, Giarda, Elisa, Verpelli, Chiara, Kilstrup-Nielsen, Charlotte, Sala, Carlo, Kalscheuer, Vera M., Broccoli, Vania
Published in Nature cell biology (01.09.2012)
Published in Nature cell biology (01.09.2012)
Get full text
Journal Article
AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy
Morabito, Giuseppe, Giannelli, Serena G., Ordazzo, Gabriele, Bido, Simone, Castoldi, Valerio, Indrigo, Marzia, Cabassi, Tommaso, Cattaneo, Stefano, Luoni, Mirko, Cancellieri, Cinzia, Sessa, Alessandro, Bacigaluppi, Marco, Taverna, Stefano, Leocani, Letizia, Lanciego, José L., Broccoli, Vania
Published in Molecular therapy (06.12.2017)
Published in Molecular therapy (06.12.2017)
Get full text
Journal Article
Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
Colasante, Gaia, Rubio, Alicia, Massimino, Luca, Broccoli, Vania
Published in Frontiers in neuroscience (26.03.2019)
Published in Frontiers in neuroscience (26.03.2019)
Get full text
Journal Article
Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients
Santambrogio, Paolo, Dusi, Sabrina, Guaraldo, Michela, Rotundo, Luisa Ida, Broccoli, Vania, Garavaglia, Barbara, Tiranti, Valeria, Levi, Sonia
Published in Neurobiology of disease (01.09.2015)
Published in Neurobiology of disease (01.09.2015)
Get full text
Journal Article
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
Piazza, Rocco, Magistroni, Vera, Redaelli, Sara, Mauri, Mario, Massimino, Luca, Sessa, Alessandro, Peronaci, Marco, Lalowski, Maciej, Soliymani, Rabah, Mezzatesta, Caterina, Pirola, Alessandra, Banfi, Federica, Rubio, Alicia, Rea, Delphine, Stagno, Fabio, Usala, Emilio, Martino, Bruno, Campiotti, Leonardo, Merli, Michele, Passamonti, Francesco, Onida, Francesco, Morotti, Alessandro, Pavesi, Francesca, Bregni, Marco, Broccoli, Vania, Baumann, Marc, Gambacorti-Passerini, Carlo
Published in Nature communications (06.06.2018)
Published in Nature communications (06.06.2018)
Get full text
Journal Article
Site-specific integration and tailoring of cassette design for sustainable gene transfer
Lombardo, Angelo, Cesana, Daniela, Genovese, Pietro, Di Stefano, Bruno, Provasi, Elena, Colombo, Daniele F, Neri, Margherita, Magnani, Zulma, Cantore, Alessio, Lo Riso, Pietro, Damo, Martina, Pello, Oscar M, Holmes, Michael C, Gregory, Philip D, Gritti, Angela, Broccoli, Vania, Bonini, Chiara, Naldini, Luigi
Published in Nature methods (01.10.2011)
Published in Nature methods (01.10.2011)
Get full text
Journal Article