Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor
Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I, Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y, Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B, Kraut, Norbert, Lito, Piro
Published in Nature (London) (06.07.2023)
Published in Nature (London) (06.07.2023)
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Journal Article
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor
Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Abstract B103: Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma
Tedeschi, Antonio, Schaaf, Otmar, Gmachl, Michael, Herdeis, Lorenz, Rocchetti, Francesca, Popow, Johannes, Schischlik, Fiorella, Gerlach, Daniel, Lipp, Jesse, Bröker, Joachim, Mantoulidis, Andreas, Smethurst, Chris, Kessler, Dirk, Boettcher, Jark, Wunberg, Tobias, Santoro, Valeria, Waterson, Alex, Phan, Jason, Little, Andrew, Abbott, Jason, Sun, Qi, Fesik, Stephen, Mcconnell, Darryl, Pearson, Mark A., Kraut, Norbert, Rudolph, Dorothea
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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Abstract A085: BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in preclinical models and validates wild-type amplified KRAS as a therapeutic target
Tedeschi, Antonio, Herdeis, Lorenz, Santoro, Valeria, Savarese, Fabio, Wilding, Birgit, Treu, Matthias, Fuchs, Julian, Bröker, Joachim, Wunberg, Tobias, Gmachl, Michael, Klaus, Rumpel, Schischlik, Fiorella, Lipp, Jesse, Peng, David H., Williams, Mariah, Deckard, Charles, Ramamoorthy, Vandhana, Daniele, Joseph R., Ajani, Jaffer A., Meric-Bernstam, Funda, Vellano, Christopher P., Marszalek, Joseph R., Heffernan, Timothy P., McConnell, Darryl, Pearson, Mark, Kraut, Norbert, Rudolph, Dorothea
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Multicentre evaluation of a second generation point-of-care assay with an extended range for the determination of N-terminal pro-brain natriuretic peptide
Jørgensen, Bo, Bertsch, Thomas, Bröker, Hans-Joachim, Schäfer, Markus, Chapelle, Jean-Paul, Gadisseur, Romy, Cowie, Martin R, Dikkeschei, Bert, Gurr, Eberhard, Hayen, Wiebke, Hafner, Gerd, Stiegler, Yuriko, Schönherr, Hans-Robert, Strasser, Ruth H, Weidtmann, Britta, Folkerts, Henning, Zugck, Christian, Hofmann, Kerstin, Zerback, Rainer
Published in Clinical laboratory (Heidelberg) (2012)
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Published in Clinical laboratory (Heidelberg) (2012)
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Abstract A087: BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical models
Peng, David H, Tedeschi, Antonio, Herdeis, Lorenz, Savarese, Fabio, Rocchetti, Francesca, Johannes, Popow, Huber, Heinrich J, Melillo, Nicola, Dickinson, Jake, Mistry, Hitesh B, Wilding, Birgit, Treu, Matthias, Fuchs, Julian, Broker, Joachim, Wunberg, Tobias, Schischlik, Fiorella, Lipp, Jesse, Ramamoorthy, Vandhana, Daniele, Joseph R, Kopetz, Scott, Kim, Michael, Gibbons, Don L, Vellano, Christopher P, Marszalek, Joseph R, Heffernan, Timothy P, McConnell, Darryl, Pearson, Mark, Kraut, Norbert, Rudolph, Dorothea
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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