Inhibition of proteasome deubiquitinating activity as a new cancer therapy
D'Arcy, Pádraig, Brnjic, Slavica, Olofsson, Maria Hägg, Fryknäs, Mårten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig
Published in Nature medicine (01.12.2011)
Published in Nature medicine (01.12.2011)
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Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress
Marino, Maria Lucia, Pellegrini, Paola, Di Lernia, Giuseppe, Djavaheri-Mergny, Mojgan, Brnjic, Slavica, Zhang, Xiaonan, Hägg, Maria, Linder, Stig, Fais, Stefano, Codogno, Patrice, De Milito, Angelo
Published in The Journal of biological chemistry (31.08.2012)
Published in The Journal of biological chemistry (31.08.2012)
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Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation
Hillert, Ellin-Kristina, Brnjic, Slavica, Zhang, Xiaonan, Mazurkiewicz, Magdalena, Saei, Amir Ata, Mofers, Arjan, Selvaraju, Karthik, Zubarev, Roman, Linder, Stig, D'Arcy, Padraig
Published in Cancer letters (28.04.2019)
Published in Cancer letters (28.04.2019)
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Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters
Fayad, Walid, Fryknäs, Mårten, Brnjic, Slavica, Olofsson, Maria Hägg, Larsson, Rolf, Linder, Stig
Published in PloS one (02.10.2009)
Published in PloS one (02.10.2009)
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Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three‐dimensional carcinoma culture model
Fayad, Walid, Brnjic, Slavica, Berglind, Daniel, Blixt, Susanna, Shoshan, Maria C., Berndtsson, Maria, Olofsson, Maria Hägg, Linder, Stig
Published in International journal of cancer (15.11.2009)
Published in International journal of cancer (15.11.2009)
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Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling
Maruwge, Wessen, D'Arcy, Pádraig, Folin, Annika, Brnjic, Slavica, Wejde, Johan, Davis, Anthony, Erlandsson, Fredrik, Bergh, Jonas, Brodin, Bertha
Published in OncoTargets and therapy (01.11.2008)
Published in OncoTargets and therapy (01.11.2008)
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Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress
Brnjic, Slavica, Mazurkiewicz, Magdalena, Fryknäs, Mårten, Sun, Chao, Zhang, Xiaonan, Larsson, Rolf, D'Arcy, Pádraig, Linder, Stig
Published in Antioxidants & redox signaling (10.12.2014)
Published in Antioxidants & redox signaling (10.12.2014)
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Journal Article
Abstract 1736: The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress
Mazurkiewicz, Magdalena, Brnjic, Slavica, Fryknäs, Mårten, Sun, Chao, Zhang, Xiaonan, Larsson, Rolf, D'Arcy, Pádraig, Linder, Stig
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Abstract B18: Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress and activation of JNK/AP1 mediated signaling
D'Arcy, Padraig, Brnjic, Slavica, Mazurkiewicz, Magdalena, Linder, Stig
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
Kolosenko, Iryna, Fryknäs, Mårten, Forsberg, Sofi, Johnsson, Per, Cheon, HyeonJoo, Holvey‐Bates, Elise G., Edsbäcker, Elin, Pellegrini, Paola, Rassoolzadeh, Hanif, Brnjic, Slavica, Larsson, Rolf, Stark, George R., Grandér, Dan, Linder, Stig, Tamm, Katja Pokrovskaja, De Milito, Angelo
Published in International journal of cancer (15.02.2015)
Published in International journal of cancer (15.02.2015)
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Journal Article
The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress
Mazurkiewicz, Magdalena, Brnjic, Slavica, Fryknas, Marten, Sun, Chao, Zhang, Xiaonan, Larsson, Rolf, D'Arcy, Padraig, Linder, Stig
Published in CANCER RESEARCH (2015)
Published in CANCER RESEARCH (2015)
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Conference Proceeding
Abstract 3999: Spontaneous time-dependent accumulation of interferon-regulatory factor 9 induces chemo-resistance in colon carcinoma cells independently of STAT1 signaling
Kolosenko, Iryna, Fryknäs, Mårten, Rassoolzadeh, Hanif, Pellegrini, Paola, Brnjic, Slavica, Johnsson, Per, Di Lernia, Giuseppe, Grander, Dan, Larsson, Rolf, Pokrovskaja, Katja, Linder, Stig, De Milito, Angelo De Milito
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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254 : Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding
Tamm, Katja Pokrovskaja, Kolosenko, Iryna, Fryknäs, Mårten, Johnsson, Per, Forsberg, Sofi, Brnjic, Slavica, Rassoolzadeh, Hanif, Pellegrini, Paola, Grandér, Dan, Larsson, Rolf, Linder, Stig, Milito, Angelo De
Published in Cytokine (Philadelphia, Pa.) (01.09.2013)
Published in Cytokine (Philadelphia, Pa.) (01.09.2013)
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254
Tamm, Katja Pokrovskaja, Kolosenko, Iryna, Fryknäs, Mårten, Johnsson, Per, Forsberg, Sofi, Brnjic, Slavica, Rassoolzadeh, Hanif, Pellegrini, Paola, Grandér, Dan, Larsson, Rolf, Linder, Stig, Milito, Angelo De
Published in Cytokine (Philadelphia, Pa.) (01.09.2013)
Published in Cytokine (Philadelphia, Pa.) (01.09.2013)
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Abstract C84: Inhibition of proteasome deubiquitinating activity as a novel cancer therapy
D'Arcy, Padraig, Brnjic, Slavica, Olofsson, Maria H., Fryknas, Marten, Lindsten, Kristina, De Cesare, Michelandrea, Perego, Paola, Sadeghi, Behnam, Hassan, Moustapha, Larsson, Rolf, Linder, Stig T.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Hernlund, Emma, Olofsson, Maria Hägg, Fayad, Walid, Fryknäs, Mårten, Lesiak-Mieczkowska, Karolina, Zhang, Xiaonan, Brnjic, Slavica, Schmidt, Vivien, D’Arcy, Padraig, Sjöblom, Tobias, Milito, Angelo De, Larsson, Rolf, Linder, Stig
Published in European journal of cancer (1990) (01.02.2012)
Published in European journal of cancer (1990) (01.02.2012)
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Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment
Gullbo, Joachim, Fryknäs, Mårten, Rickardson, Linda, Darcy, Padraig, Hägg, Maria, Wickström, Malin, Hassan, Sadia, Westman, Gunnar, Brnjic, Slavica, Nygren, Peter, Linder, Stig, Larsson, Rolf
Published in Biochemical pharmacology (2011)
Published in Biochemical pharmacology (2011)
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Journal Article
Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding
Tamm, Katia Pokrovskaja, Kolosenko, Iryna, Fryknäs, Mårten, Johnsson, Per, Forsberg, Sofi, Brnjic, Slavica, Rassoolzadeh, Hanif, Pellegrini, Paola, Grander, Dan, Larsson, Rolf, Linder, Stig, De Milito, Angelo
Published in CYTOKINE (2013)
Published in CYTOKINE (2013)
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Conference Proceeding