Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Schwitalla, Sarah, Fingerle, Alexander A., Cammareri, Patrizia, Nebelsiek, Tim, Göktuna, Serkan I., Ziegler, Paul K., Canli, Ozge, Heijmans, Jarom, Huels, David J., Moreaux, Guenievre, Rupec, Rudolf A., Gerhard, Markus, Schmid, Roland, Barker, Nick, Clevers, Hans, Lang, Roland, Neumann, Jens, Kirchner, Thomas, Taketo, Makoto M., van den Brink, Gijs R., Sansom, Owen J., Arkan, Melek C., Greten, Florian R.
Published in Cell (17.01.2013)
Published in Cell (17.01.2013)
Get full text
Journal Article
Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling
Spaan, Claudia N., Smit, Wouter L., van Lidth de Jeude, Jooske F., Meijer, Bartolomeus J., Muncan, Vanesa, van den Brink, Gijs R., Heijmans, Jarom
Published in Cell death & disease (21.06.2019)
Published in Cell death & disease (21.06.2019)
Get full text
Journal Article
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response
Heijmans, Jarom, van Lidth de Jeude, Jooske F, Koo, Bon-Kyoung, Rosekrans, Sanne L, Wielenga, Mattheus C B, van de Wetering, Marc, Ferrante, Marc, Lee, Amy S, Onderwater, Jos J M, Paton, James C, Paton, Adrienne W, Mommaas, A Mieke, Kodach, Liudmila L, Hardwick, James C, Hommes, Daniël W, Clevers, Hans, Muncan, Vanesa, van den Brink, Gijs R
Published in Cell reports (Cambridge) (01.04.2013)
Published in Cell reports (Cambridge) (01.04.2013)
Get full text
Journal Article
Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease
Levin, Alon D., Wildenberg, Manon E., van den Brink, Gijs R.
Published in Journal of Crohn's and colitis (01.08.2016)
Published in Journal of Crohn's and colitis (01.08.2016)
Get full text
Journal Article
FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
Hansen, Ivo S., Krabbendam, Lisette, Bernink, Jochem H., Loayza-Puch, Fabricio, Hoepel, Willianne, van Burgsteden, Johan A., Kuijper, Elsa C., Buskens, Christianne J., Bemelman, Willem A., Zaat, Sebastiaan A. J., Agami, Reuven, Vidarsson, Gestur, van den Brink, Gijs R., de Jong, Esther C., Wildenberg, Manon E., Baeten, Dominique L. P., Everts, Bart, den Dunnen, Jeroen
Published in Nature communications (28.02.2018)
Published in Nature communications (28.02.2018)
Get full text
Journal Article
Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling
Koelink, Pim J, Bloemendaal, Felicia M, Li, Bofeng, Westera, Liset, Vogels, Esther W M, van Roest, Manon, Gloudemans, Anouk K, van 't Wout, Angelique B, Korf, Hannelie, Vermeire, Séverine, te Velde, Anje A, Ponsioen, Cyriel Y, D'Haens, Geert RAM, Verbeek, J Sjef, Geiger, Terrence L, Wildenberg, Manon E, van den Brink, Gijs R
Published in Gut (01.06.2020)
Published in Gut (01.06.2020)
Get full text
Journal Article
ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy
Wielenga, Mattheus C.B., Colak, Selcuk, Heijmans, Jarom, van Lidth de Jeude, Jooske F., Rodermond, Hans M., Paton, James C., Paton, Adrienne W., Vermeulen, Louis, Medema, Jan Paul, van den Brink, Gijs R.
Published in Cell reports (Cambridge) (20.10.2015)
Published in Cell reports (Cambridge) (20.10.2015)
Get full text
Journal Article
Persistent Mesorectal Inflammatory Activity is Associated With Complications After Proctectomy in Crohn’s Disease
de Groof, E Joline, van der Meer, Jonathan H M, Tanis, Pieter J, de Bruyn, Jessica R, van Ruler, Oddeke, D’Haens, Geert R A M, van den Brink, Gijs R, Bemelman, Willem A, Wildenberg, Manon E, Buskens, Christianne J
Published in Journal of Crohn's and colitis (26.03.2019)
Published in Journal of Crohn's and colitis (26.03.2019)
Get full text
Journal Article
Epithelium-derived Indian Hedgehog restricts stromal expression of ErbB family members that drive colonic tumor cell proliferation
Westendorp, Florien, Karpus, Olga N., Koelink, Pim J., Vermeulen, Jacqueline L. M., Meisner, Sander, Koster, Jan, Büller, Nikè V. J. A., Wildenberg, Manon E., Muncan, Vanesa, van den Brink, Gijs R.
Published in Oncogene (04.03.2021)
Published in Oncogene (04.03.2021)
Get full text
Journal Article
HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis
Zimberlin, Cheryl D, Lancini, Cesare, Sno, Rachel, Rosekrans, Sanne L, McLean, Chelsea M, Vlaming, Hanneke, van den Brink, Gijs R, Bots, Michael, Medema, Jan Paul, Dannenberg, Jan-Hermen
Published in The FASEB journal (01.05.2015)
Published in The FASEB journal (01.05.2015)
Get more information
Journal Article
Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2
Meijer, Bartolomeus J., Smit, Wouter L., Koelink, Pim J., Westendorp, Barbara F., de Boer, Ruben J., van der Meer, Jonathan H. M., Vermeulen, Jacqueline L. M., Paton, James C., Paton, Adrienne W., Qin, Jun, Dekker, Evelien, Muncan, Vanesa, van den Brink, Gijs R., Heijmans, Jarom
Published in Scientific reports (10.05.2021)
Published in Scientific reports (10.05.2021)
Get full text
Journal Article
The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC
Schilderink, Ronald, Verseijden, Caroline, Seppen, Jurgen, Muncan, Vanesa, van den Brink, Gijs R, Lambers, Tim T, van Tol, Eric A, de Jonge, Wouter J
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2016)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2016)
Get full text
Journal Article
Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study
Duijvestein, Marjolijn, Vos, Anne Christine W, Roelofs, Helene, Wildenberg, Manon E, Wendrich, Barbara B, Verspaget, Henricus W, Kooy-Winkelaar, Engelina M C, Koning, Frits, Zwaginga, Jaap Jan, Fidder, Herma H, Verhaar, Auke P, Fibbe, Willem E, van den Brink, Gijs R, Hommes, Daniel W
Published in Gut (01.12.2010)
Published in Gut (01.12.2010)
Get full text
Journal Article
Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth
Karpus, Olga N., Westendorp, B. Florien, Vermeulen, Jacqueline L.M., Meisner, Sander, Koster, Jan, Muncan, Vanesa, Wildenberg, Manon E., van den Brink, Gijs R.
Published in Cell reports (Cambridge) (26.03.2019)
Published in Cell reports (Cambridge) (26.03.2019)
Get full text
Journal Article
Epithelial argininosuccinate synthetase is dispensable for intestinal regeneration and tumorigenesis
van der Meer, Jonathan H. M., de Boer, Ruben J., Meijer, Bartolomeus J., Smit, Wouter L., Vermeulen, Jacqueline L. M., Meisner, Sander, van Roest, Manon, Koelink, Pim J., Dekker, Evelien, Hakvoort, Theodorus B. M., Koster, Jan, Hawinkels, Lukas J. A. C., Heijmans, Jarom, Struijs, Eduard A., Boermeester, Marja A., van den Brink, Gijs R., Muncan, Vanesa
Published in Cell death & disease (01.10.2021)
Published in Cell death & disease (01.10.2021)
Get full text
Journal Article
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
Gerling, Marco, Büller, Nikè V. J. A., Kirn, Leonard M., Joost, Simon, Frings, Oliver, Englert, Benjamin, Bergström, Åsa, Kuiper, Raoul V., Blaas, Leander, Wielenga, Mattheus C. B., Almer, Sven, Kühl, Anja A., Fredlund, Erik, van den Brink, Gijs R., Toftgård, Rune
Published in Nature communications (05.08.2016)
Published in Nature communications (05.08.2016)
Get full text
Journal Article
MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium
Pereira, Bruno, Amaral, Ana L, Dias, Alexandre, Mendes, Nuno, Muncan, Vanesa, Silva, Ana R, Thibert, Chantal, Radu, Anca G, David, Leonor, Máximo, Valdemar, van den Brink, Gijs R, Billaud, Marc, Almeida, Raquel
Published in EMBO reports (03.04.2020)
Published in EMBO reports (03.04.2020)
Get full text
Journal Article
Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning
Navis, Marit, Martins Garcia, Tânia, Renes, Ingrid B, Vermeulen, Jacqueline LM, Meisner, Sander, Wildenberg, Manon E, van den Brink, Gijs R, van Elburg, Ruurd M, Muncan, Vanesa
Published in EMBO reports (01.02.2019)
Published in EMBO reports (01.02.2019)
Get full text
Journal Article
Impaired autophagy leads to abnormal dendritic cell–epithelial cell interactions
Strisciuglio, Caterina, Duijvestein, Marjolijn, Verhaar, Auke P., Vos, Anne Christine W., den Brink, Gijs R. van, Hommes, Daniel W., Wildenberg, Manon E.
Published in Journal of Crohn's and colitis (01.08.2013)
Published in Journal of Crohn's and colitis (01.08.2013)
Get full text
Journal Article