In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding
Bate, Neil, Savva, Christos G, Moody, Peter C E, Brown, Edward A, Evans, Sian E, Ball, Jonathan K, Schwabe, John W R, Sale, Julian E, Brindle, Nicholas P J
Published in PLoS pathogens (01.07.2022)
Published in PLoS pathogens (01.07.2022)
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Regulated Proteolytic Processing of Tie1 Modulates Ligand Responsiveness of the Receptor-tyrosine Kinase Tie2
Marron, Marie B., Singh, Harprit, Tahir, Tariq A., Kavumkal, Jais, Kim, Hak-Zoo, Koh, Gou Young, Brindle, Nicholas P.J.
Published in The Journal of biological chemistry (19.10.2007)
Published in The Journal of biological chemistry (19.10.2007)
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Signaling and Functions of Angiopoietin-1 in Vascular Protection
Brindle, Nicholas P.J, Saharinen, Pipsa, Alitalo, Kari
Published in Circulation research (28.04.2006)
Published in Circulation research (28.04.2006)
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Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations
MORRIS, Paul N, DUNMORE, Benjamin J, TADROS, Amir, MARCHUK, Douglas A, DARLAND, Diane C, D'AMORE, Patricia A, BRINDLE, Nicholas P. J
Published in Journal of molecular medicine (Berlin, Germany) (01.01.2005)
Published in Journal of molecular medicine (Berlin, Germany) (01.01.2005)
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Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display
Brindle, Nicholas P.J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.
Published in The Journal of biological chemistry (15.11.2013)
Published in The Journal of biological chemistry (15.11.2013)
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ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1
Tadros, Amir, Hughes, David P., Dunmore, Benjamin J., Brindle, Nicholas P.J.
Published in Blood (15.12.2003)
Published in Blood (15.12.2003)
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Journal Article
Molecular control of angiopoietin signalling
Singh, Harprit, Tahir, Tariq A, Alawo, Deborah O A, Issa, Eyad, Brindle, Nicholas P J
Published in Biochemical Society transactions (01.12.2011)
Published in Biochemical Society transactions (01.12.2011)
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Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1
Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.
Published in European journal of cell biology (01.09.2010)
Published in European journal of cell biology (01.09.2010)
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Development of an Orthogonal Tie2 Ligand Resistant to Inhibition by Ang2
Issa, Eyad, Moss, Andrew J, Fischer, Marlies, Kang, Mandeep, Ahmed, Sultan, Farah, Hussein, Bate, Neil, Giakomidi, Despoina, Brindle, Nicholas PJ
Published in Molecular pharmaceutics (04.09.2018)
Published in Molecular pharmaceutics (04.09.2018)
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