Neoantigen-specific stem cell memory-like CD4 + T cells mediate CD8 + T cell-dependent immunotherapy of MHC class II-negative solid tumors
Brightman, Spencer E, Becker, Angelica, Thota, Rukman R, Naradikian, Martin S, Chihab, Leila, Zavala, Karla Soria, Ramamoorthy Premlal, Ashmitaa Logandha, Griswold, Ryan Q, Dolina, Joseph S, Cohen, Ezra E W, Miller, Aaron M, Peters, Bjoern, Schoenberger, Stephen P
Published in Nature immunology (01.08.2023)
Published in Nature immunology (01.08.2023)
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Linked CD4+/CD8+ T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Dolina, Joseph S., Lee, Joey, Brightman, Spencer E., McArdle, Sara, Hall, Samantha M., Thota, Rukman R., Zavala, Karla S., Lanka, Manasa, Ramamoorthy Premlal, Ashmitaa Logandha, Greenbaum, Jason A., Cohen, Ezra E. W., Peters, Bjoern, Schoenberger, Stephen P.
Published in The Journal of clinical investigation (01.09.2023)
Published in The Journal of clinical investigation (01.09.2023)
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Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination
Dowling, David J, Barman, Soumik, Smith, Alyson J, Borriello, Francesco, Chaney, Danielle, Brightman, Spencer E, Melhem, Gandolina, Brook, Byron, Menon, Manisha, Soni, Dheeraj, Schüller, Simone, Siram, Karthik, Nanishi, Etsuro, Bazin, Hélène G, Burkhart, David J, Levy, Ofer, Evans, Jay T
Published in Scientific reports (18.10.2022)
Published in Scientific reports (18.10.2022)
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Tumor cells fail to present MHC-II-restricted epitopes derived from oncogenes to CD4+ T cells
Brightman, Spencer E, Naradikian, Martin S, Thota, Rukman R, Becker, Angelica, Montero, Leslie, Bahmanof, Milad, Premlal, Ashmitaa Logandha Ramamoorthy, Greenbaum, Jason A, Peters, Bjoern, Cohen, Ezra Ew, Miller, Aaron M, Schoenberger, Stephen P
Published in JCI insight (24.01.2023)
Published in JCI insight (24.01.2023)
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Harnessing neoantigen specific CD4 T cells for cancer immunotherapy
Brightman, Spencer E., Naradikian, Martin S., Miller, Aaron M., Schoenberger, Stephen P.
Published in Journal of leukocyte biology (01.04.2020)
Published in Journal of leukocyte biology (01.04.2020)
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Author Correction: Neoantigen-specific stem cell memory-like CD4 + T cells mediate CD8 + T cell-dependent immunotherapy of MHC class II-negative solid tumors
Brightman, Spencer E, Becker, Angelica, Thota, Rukman R, Naradikian, Martin S, Chihab, Leila, Zavala, Karla Soria, Ramamoorthy Premlal, Ashmitaa Logandha, Griswold, Ryan Q, Dolina, Joseph S, Cohen, Ezra E W, Miller, Aaron M, Peters, Bjoern, Schoenberger, Stephen P
Published in Nature immunology (01.08.2023)
Published in Nature immunology (01.08.2023)
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A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer
Miller, Aaron M, Koşaloğlu-Yalçın, Zeynep, Westernberg, Luise, Montero, Leslie, Bahmanof, Milad, Frentzen, Angela, Lanka, Manasa, Logandha Ramamoorthy Premlal, Ashmitaa, Seumois, Gregory, Greenbaum, Jason, Brightman, Spencer E, Soria Zavala, Karla, Thota, Rukman R, Naradikian, Martin S, Makani, Samir S, Lippman, Scott M, Sette, Alessandro, Cohen, Ezra E W, Peters, Bjoern, Schoenberger, Stephen P
Published in Science translational medicine (28.02.2024)
Published in Science translational medicine (28.02.2024)
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Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
Queenan, Anne Marie, Dowling, David J., Cheng, Wing Ki, Faé, Kellen, Fernandez, Jeffrey, Flynn, Peter J., Joshi, Sweta, Brightman, Spencer E., Ramirez, Juan, Serroyen, Jan, Wiertsema, Selma, Fortanier, Alexandre, van den Dobbelsteen, Germie, Levy, Ofer, Poolman, Jan
Published in Vaccine (03.01.2019)
Published in Vaccine (03.01.2019)
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From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation
Soni, Dheeraj, Borriello, Francesco, Scott, David A., Feru, Frederic, DeLeon, Maria, Brightman, Spencer E., Cheng, Wing Ki, Melhem, Gandolina, Smith, Jennifer A., Ramirez, Juan C., Barman, Soumik, Cameron, Michael, Kelly, Aisling, Walker, Kristina, Nanishi, Etsuro, van Haren, Simon Daniel, Phan, Tony, Qi, Yizhi, Kinsey, Robert, Raczy, Michal M., Ozonoff, Al, Pettengill, Matthew A., Hubbell, Jeffery A., Fox, Christopher B., Dowling, David J., Levy, Ofer
Published in Science advances (05.07.2024)
Published in Science advances (05.07.2024)
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신규 이미다조피리미딘 화합물 및 그의 용도
BRIGHTMAN SPENCER E, LEVY OFER, DOWLING DAVID J, SCOTT DAVID A, FERU FREDERIC, BORRIELLO FRANCESCO
Year of Publication 22.07.2020
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Year of Publication 22.07.2020
Patent
인간 면역 반응을 조정하기 위한 이미다조피리미딘의 용도
BRIGHTMAN SPENCER E, LEVY OFER, DOWLING DAVID J, SCOTT DAVID A, FERU FREDERIC, BORRIELLO FRANCESCO
Year of Publication 22.07.2020
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Year of Publication 22.07.2020
Patent
TCR-engineered neoantigen-specific CD4+ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
Brightman, Spencer E, Becker, Angelica, Thota, Rukman, Naradikian, Martin S, Griswold, Ryan, Dolina, Joseph S, Schoenberger, Stephen P
Published in The Journal of immunology (1950) (01.05.2022)
Published in The Journal of immunology (1950) (01.05.2022)
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Linked [CD4.sup.+]/[CD8.sup.+] T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Dolina, Joseph S, Lee, Joey, Brightman, Spencer E, McArdle, Sara, Hall, Samantha M, Thota, Rukman R, Zavala, Karla S, Lanka, Manasa, Premiai, Ashmitaa Logandha Ramamoorthy, Greenbaum, Jason A, Cohen, Ezra E.W, Peters, Bjoern, Schoenberger, Stephen P
Published in The Journal of clinical investigation (01.09.2023)
Published in The Journal of clinical investigation (01.09.2023)
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Journal Article
Linked CD4 + /CD8 + T cell neoantigen vaccination overcomes immune checkpoint blockade resistance and enables tumor regression
Dolina, Joseph S, Lee, Joey, Brightman, Spencer E, McArdle, Sara, Hall, Samantha M, Thota, Rukman R, Lanka, Manasa, Premlal, Ashmitaa Logandha Ramamoorthy, Greenbaum, Jason A, Cohen, Ezra E W, Peters, Bjoern, Schoenberger, Stephen P
Published in bioRxiv : the preprint server for biology (07.05.2023)
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Published in bioRxiv : the preprint server for biology (07.05.2023)
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N-[5-(IMIDAZO[1,2-A]PYRIMIDIN-2-YL)PHENYL]-BENZAMIDE AND -BENZENEACETAMIDE DERIVATIVES AS TNF STIMULATORS FOR THE TREATMENT OF E.G. INFECTIOUS DISEASES AND CANCER
FERU, Frederic, LEVY, Ofer, BORRIELLO, Francesco, BRIGHTMAN, Spencer E, DOWLING, David J, SCOTT, David, A
Year of Publication 14.08.2024
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Year of Publication 14.08.2024
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Imidazopyrimidine compounds and uses thereof
Levy, Ofer, Scott, David A, Feru, Frederic, Dowling, David J, Borriello, Francesco, Brightman, Spencer E
Year of Publication 13.06.2023
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Year of Publication 13.06.2023
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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
Levy, Ofer, Scott, David A, Dowling, David J, Borriello, Francesco, Brightman, Spencer E
Year of Publication 27.04.2023
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Year of Publication 27.04.2023
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NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF
Levy, Ofer, Scott, David A, Feru, Frederic, Dowling, David J, Borriello, Francesco, Brightman, Spencer E
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE
Levy, Ofer, Scott, David A, Dowling, David J, Borriello, Francesco, Brightman, Spencer E
Year of Publication 21.04.2022
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Year of Publication 21.04.2022
Patent