Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis
Ness, Daniel, Ren, Zhao, Gardai, Shyra, Sharpnack, Douglas, Johnson, Victor J, Brennan, Richard J, Brigham, Elizabeth F, Olaharski, Andrew J
Published in PloS one (14.06.2013)
Published in PloS one (14.06.2013)
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Partial Reduction of BACE1 Has Dramatic Effects on Alzheimer Plaque and Synaptic Pathology in APP Transgenic Mice
McConlogue, Lisa, Buttini, Manuel, Anderson, John P., Brigham, Elizabeth F., Chen, Karen S., Freedman, Stephen B., Games, Dora, Johnson-Wood, Kelly, Lee, Michael, Zeller, Michelle, Liu, Weiqun, Motter, Ruth, Sinha, Sukanto
Published in The Journal of biological chemistry (07.09.2007)
Published in The Journal of biological chemistry (07.09.2007)
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Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
Lue, Lih-Fen, Rydel, Russell, Brigham, Elizabeth F., Yang, Li-Bang, Hampel, Harald, Murphy Jr, Greer M., Brachova, Libuse, Yan, Shi-Du, Walker, Douglas G., Shen, Yong, Rogers, Joseph
Published in Glia (01.07.2001)
Published in Glia (01.07.2001)
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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model
Truong, Anh P., Tóth, Gergley, Probst, Gary D., Sealy, Jennifer M., Bowers, Simeon, Wone, David W.G., Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Wu, Jing, Peterson, Brian T., Ruslim, Lany, Bova, Michael P., Kholodenko, Dora, Motter, Ruth N., Bard, Frédérique, Santiago, Pamela, Ni, Huifang, Chian, David, Soriano, Ferdie, Cole, Tracy, Brigham, Elizabeth F., Wong, Karina, Zmolek, Wes, Goldbach, Erich, Samant, Bhushan, Chen, Linda, Zhang, Hongbing, Nakamura, David F., Quinn, Kevin P., Yednock, Ted A., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia
Brigham, Elizabeth, Johnston, Tom, Brown, Carl, Holt, Jonathon, Fox, Susan, Hill, Michael, Howson, Patrick, Brotchie, Jonathan, Nguyen, Jack
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2018)
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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
Inglis, Kelly J., Chereau, David, Brigham, Elizabeth F., Chiou, San-San, Schöbel, Susanne, Frigon, Normand L., Yu, Mei, Caccavello, Russell J., Nelson, Seth, Motter, Ruth, Wright, Sarah, Chian, David, Santiago, Pamela, Soriano, Ferdie, Ramos, Carla, Powell, Kyle, Goldstein, Jason M., Babcock, Michael, Yednock, Ted, Bard, Frederique, Basi, Guriqbal S., Sham, Hing, Chilcote, Tamie J., McConlogue, Lisa, Griswold-Prenner, Irene, Anderson, John P.
Published in The Journal of biological chemistry (30.01.2009)
Published in The Journal of biological chemistry (30.01.2009)
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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors
Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro‑2H‑pyrazolo[4,3‑c]quinoline (ELND007): Metabolically Stable γ‑Secretase Inhibitors that Selectively Inhibit the Production of Amyloid‑β over Notch
Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors
Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Aggregated Amyloid-beta Protein Induces Cortical Neuronal Apoptosis and Concomitant "Apoptotic" Pattern of Gene Induction
Estus, Steven, Tucker, H. Michael, van Rooyen, Corlia, Wright, Sarah, Brigham, Elizabeth F, Wogulis, Mark, Rydel, Russell E
Published in The Journal of neuroscience (15.10.1997)
Published in The Journal of neuroscience (15.10.1997)
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Discovery of sulfonamide–pyrazole γ-secretase inhibitors
Mattson, Matthew N., Neitzel, Martin L., Quincy, David A., Semko, Christopher M., Garofalo, Albert W., Keim, Pamela S., Konradi, Andrei W., Pleiss, Michael A., Sham, Hing L., Brigham, Elizabeth F., Goldbach, Erich G., Zhang, Hongbin, Sauer, John-Michael, Basi, Guriqbal S.
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Basi, Guriqbal S, Hemphill, Susanna, Brigham, Elizabeth F, Liao, Anna, Aubele, Danielle L, Baker, Jeanne, Barbour, Robin, Bova, Michael, Chen, Xiao-Hua, Dappen, Michael S, Eichenbaum, Tovah, Goldbach, Erich, Hawkinson, Jon, Lawler-Herbold, Rose, Hu, Kang, Hui, Terence, Jagodzinski, Jacek J, Keim, Pamela S, Kholodenko, Dora, Latimer, Lee H, Lee, Mike, Marugg, Jennifer, Mattson, Matthew N, McCauley, Scott, Miller, James L, Motter, Ruth, Mutter, Linda, Neitzel, Martin L, Ni, Huifang, Nguyen, Lan, Quinn, Kevin, Ruslim, Lany, Semko, Christopher M, Shapiro, Paul, Smith, Jenifer, Soriano, Ferdie, Szoke, Balazs, Tanaka, Kevin, Tang, Pearl, Tucker, John A, Ye, Xiacong Michael, Yu, Mei, Wu, Jing, Xu, Ying-Zi, Garofalo, Albert W, Sauer, John Michael, Konradi, Andrei W, Ness, Daniel, Shopp, George, Pleiss, Michael A, Freedman, Stephen B, Schenk, Dale
Published in Alzheimer's research & therapy (29.12.2010)
Published in Alzheimer's research & therapy (29.12.2010)
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Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer’s disease
Neitzel, Martin L., Aubele, Danielle L., Marugg, Jennifer L., Jagodzinski, Jacek J., Konradi, Andrei W., Pleiss, Michael A., Szoke, Balazs, Zmolek, Wes, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Bova, Michael P., Hemphill, Susanna, Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)
Ye, Xiaocong M., Konradi, Andrei W., Smith, Jenifer, Aubele, Danielle L., Garofalo, Albert W., Marugg, Jennifer, Neitzel, Marty L., Semko, Chris M., Sham, Hing L., Sun, Minghua, Truong, Anh P., Wu, Jing, Zhang, Hongbin, Goldbach, Erich, Sauer, John-Michael, Brigham, Elizabeth F., Bova, Michael, Basi, Guriqbal S.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Oncostatin M and the Interleukin-6 and Soluble Interleukin-6 Receptor Complex Regulate α1-Antichymotrypsin Expression in Human Cortical Astrocytes
Kordula, Tomasz, Rydel, Russell E., Brigham, Elizabeth F., Horn, Friedemann, Heinrich, Peter C., Travis, James
Published in The Journal of biological chemistry (01.02.1998)
Published in The Journal of biological chemistry (01.02.1998)
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Journal Article
Leucine-Rich Repeat Kinase 2
Ness, Daniel, Ren, Zhao, Gardai, Shyra, Sharpnack, Douglas, Johnson, Victor J, Brennan, Richard J, Brigham, Elizabeth F, Olaharski, Andrew J
Published in PloS one (14.06.2013)
Published in PloS one (14.06.2013)
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Journal Article
Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Probst, Gary, Aubele, Danielle L., Bowers, Simeon, Dressen, Darren, Garofalo, Albert W., Hom, Roy K., Konradi, Andrei W., Marugg, Jennifer L., Mattson, Matthew N., Neitzel, Martin L., Semko, Chris M., Sham, Hing L., Smith, Jenifer, Sun, Minghua, Truong, Anh P., Ye, Xiaocong M., Xu, Ying-zi, Dappen, Michael S., Jagodzinski, Jacek J., Keim, Pamela S., Peterson, Brian, Latimer, Lee H., Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K., Quinn, Kevin P., Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F., Kholodenko, Dora, Hu, Kang, Kwong, Grace T., Lee, Michael, Liao, Anna, Motter, Ruth N., Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P., Hemphill, Susanna S., Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A., Basi, Guriqbal S.
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Journal Article
Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent [gamma]-secretase inhibitors
Aubele, Danielle L, Truong, Anh P, Dressen, Darren B, Probst, Gary D, Bowers, Simeon, Mattson, Matthew N, Semko, Chris M, Sun, Minghua, Garofalo, Albert W, Konradi, Andrei W, Sham, Hing L, Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P, Sauer, John-Michael, Brigham, Elizabeth F, Wallace, William, Nguyen, Lan, Bova, Michael P, Hemphill, Susanna S, Basi, Guriqbal
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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