Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
Hinrich, Anthony J, Jodelka, Francine M, Chang, Jennifer L, Brutman, Daniella, Bruno, Angela M, Briggs, Clark A, James, Bryan D, Stutzmann, Grace E, Bennett, David A, Miller, Steven A, Rigo, Frank, Marr, Robert A, Hastings, Michelle L
Published in EMBO molecular medicine (01.04.2016)
Published in EMBO molecular medicine (01.04.2016)
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Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology
Schrank, Sean, McDaid, John, Briggs, Clark A, Mustaly-Kalimi, Sarah, Brinks, Deanna, Houcek, Aiden, Singer, Oded, Bottero, Virginie, Marr, Robert A, Stutzmann, Grace E
Published in International journal of molecular sciences (04.02.2020)
Published in International journal of molecular sciences (04.02.2020)
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Journal Article
Sustained Hippocampal Synaptic Pathophysiology Following Single and Repeated Closed-Head Concussive Impacts
McDaid, John, Briggs, Clark A, Barrington, Nikki M, Peterson, Daniel A, Kozlowski, Dorothy A, Stutzmann, Grace E
Published in Frontiers in cellular neuroscience (31.03.2021)
Published in Frontiers in cellular neuroscience (31.03.2021)
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Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells
Bazarek, Stanley F., Thaqi, Mentor, King, Patrick, Mehta, Amol R., Patel, Ronil, Briggs, Clark A., Reisenbigler, Emily, Yousey, Jonathon E., Miller, Elis A., Stutzmann, Grace E., Marr, Robert A., Peterson, Daniel A.
Published in Frontiers in neuroscience (17.08.2023)
Published in Frontiers in neuroscience (17.08.2023)
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Journal Article
Emerging pathways driving early synaptic pathology in Alzheimer's disease
Briggs, Clark A., Chakroborty, Shreaya, Stutzmann, Grace E.
Published in Biochemical and biophysical research communications (19.02.2017)
Published in Biochemical and biophysical research communications (19.02.2017)
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Journal Article
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Sujatha M, Gronlien, Jens Halvard, Malysz, John, Briggs, Clark A, Wetterstrand, Caroline, Ween, Hilde, Curtis, Michael P, Sarris, Kathy A, Gfesser, Gregory A, El-Kouhen, Rachid, Robb, Holly M, Radek, Richard J, Marsh, Kennan C, Bunnelle, William H, Gopalakrishnan, Murali
Published in Journal of medicinal chemistry (28.05.2009)
Published in Journal of medicinal chemistry (28.05.2009)
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Journal Article
SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
Schrimpf, Michael R., Sippy, Kevin B., Briggs, Clark A., Anderson, David J., Li, Tao, Ji, Jianguo, Frost, Jennifer M., Surowy, Carol S., Bunnelle, William H., Gopalakrishnan, Murali, Meyer, Michael D.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits
Lacampagne, Alain, Liu, Xiaoping, Reiken, Steven, Bussiere, Renaud, Meli, Albano C., Lauritzen, Inger, Teich, Andrew F., Zalk, Ran, Saint, Nathalie, Arancio, Ottavio, Bauer, Charlotte, Duprat, Fabrice, Briggs, Clark A., Chakroborty, Shreaya, Stutzmann, Grace E., Shelanski, Michael L., Checler, Frederic, Chami, Mounia, Marks, Andrew R.
Published in Acta neuropathologica (01.11.2017)
Published in Acta neuropathologica (01.11.2017)
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Journal Article
Distinct Profiles of alpha 7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Halvard Groenlien, Jens, Haakerud, Monika, Ween, Hilde, Thorin-Hagene, Kirsten, Briggs, Clark A, Gopalakrishnan, Murali, Malysz, John
Published in Molecular pharmacology (01.09.2007)
Published in Molecular pharmacology (01.09.2007)
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Journal Article
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor
Faghih, Ramin, Gopalakrishnan, Murali, Briggs, Clark A
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving
Christian, Daniel T, Stefanik, Michael T, Bean, Linda A, Loweth, Jessica A, Wunsch, Amanda M, Funke, Jonathan R, Briggs, Clark A, Lyons, Joseph, Neal, Demetria, Milovanovic, Mike, D'Souza, Gary X, Stutzmann, Grace E, Nicholson, Daniel A, Tseng, Kuei Y, Wolf, Marina E
Published in The Journal of neuroscience (29.09.2021)
Published in The Journal of neuroscience (29.09.2021)
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Journal Article
Distinct Profiles of α7 nAChR Positive Allosteric Modulation Revealed by Structurally Diverse Chemotypes
Halvard Grønlien, Jens, Håkerud, Monika, Ween, Hilde, Thorin-Hagene, Kirsten, Briggs, Clark A., Gopalakrishnan, Murali, Malysz, John
Published in Molecular pharmacology (01.09.2007)
Published in Molecular pharmacology (01.09.2007)
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Journal Article
An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo
Timmermann, Daniel B., Grønlien, Jens Halvard, Kohlhaas, Kathy L., Nielsen, Elsebet Ø., Dam, Eva, Jørgensen, Tino D., Ahring, Philip K., Peters, Dan, Holst, Dorte, Chrsitensen, Jeppe K., Malysz, John, Briggs, Clark A., Gopalakrishnan, Murali, Olsen, Gunnar M.
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2007)
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Journal Article
Broad-Spectrum Efficacy across Cognitive Domains by alpha 7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Bitner, Robert S, Bunnelle, William H, Anderson, David J, Briggs, Clark A, Buccafusco, Jerry, Curzon, Peter, Decker, Michael W, Frost, Jennifer M, Gronlien, Jens Halvard, Gubbins, Earl, Li, Jinhe, Malysz, John, Markosyan, Stella, Marsh, Kennan, Meyer, Michael D, Nikkel, Arthur L, Radek, Richard J, Robb, Holly M, Timmermann, Daniel, Sullivan, James P, Gopalakrishnan, Murali
Published in The Journal of neuroscience (26.09.2007)
Published in The Journal of neuroscience (26.09.2007)
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Journal Article
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile
Malysz, John, Grønlien, Jens Halvard, Anderson, David J, Håkerud, Monika, Thorin-Hagene, Kirsten, Ween, Hilde, Wetterstrand, Caroline, Briggs, Clark A, Faghih, Ramin, Bunnelle, William H, Gopalakrishnan, Murali
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Journal Article
Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors
Briggs, Clark A, Grønlien, Jens Halvard, Curzon, Peter, Timmermann, Daniel B, Ween, Hilde, Thorin‐Hagene, Kirsten, Kerr, Paige, Anderson, David J, Malysz, John, Dyhring, Tino, Olsen, Gunnar M, Peters, Dan, Bunnelle, William H, Gopalakrishnan, Murali
Published in British journal of pharmacology (01.11.2009)
Published in British journal of pharmacology (01.11.2009)
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Journal Article
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity α4β2 subunit combination
Anderson, David J., Malysz, John, Grønlien, Jens Halvard, El Kouhen, Rachid, Håkerud, Monika, Wetterstrand, Caroline, Briggs, Clark A., Gopalakrishnan, Murali
Published in Biochemical pharmacology (01.10.2009)
Published in Biochemical pharmacology (01.10.2009)
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