Efficient multi-objective molecular optimization in a continuous latent space
Winter, Robin, Montanari, Floriane, Steffen, Andreas, Briem, Hans, Noé, Frank, Clevert, Djork-Arné
Published in Chemical science (Cambridge) (14.09.2019)
Published in Chemical science (Cambridge) (14.09.2019)
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Journal Article
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
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Journal Article
Synthesis-Aware Generation of Structural Analogues
Dolfus, Uschi, Briem, Hans, Rarey, Matthias
Published in Journal of chemical information and modeling (08.08.2022)
Published in Journal of chemical information and modeling (08.08.2022)
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Journal Article
Visualizing Generic Reaction Patterns
Dolfus, Uschi, Briem, Hans, Rarey, Matthias
Published in Journal of chemical information and modeling (10.10.2022)
Published in Journal of chemical information and modeling (10.10.2022)
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Journal Article
Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
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Journal Article
An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer — against all odds?
Follmann, Markus, Briem, Hans, Steinmeyer, Andreas, Hillisch, Alexander, Schmitt, Monika H., Haning, Helmut, Meier, Heinrich
Published in Drug discovery today (01.03.2019)
Published in Drug discovery today (01.03.2019)
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Journal Article
Diversity-oriented multi-compound synthesis optimization
Briem, Hans, Gläser, Lukas, Mogk, Georg, Schaudt, Oliver
Published in Reaction chemistry & engineering (20.08.2024)
Published in Reaction chemistry & engineering (20.08.2024)
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Journal Article
Mono- and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models
Böhnke, Niels, Indrevoll, Bård, Hammer, Stefanie, Papple, Alex, Kristian, Alexander, Briem, Hans, Celik, Arif, Mumberg, Dominik, Cuthbertson, Alan, Zitzmann-Kolbe, Sabine
Published in European journal of nuclear medicine and molecular imaging (01.02.2024)
Published in European journal of nuclear medicine and molecular imaging (01.02.2024)
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Journal Article
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer
Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Journal Article
Prioritizing Small Sets of Molecules for Synthesis through in‐silico Tools: A Comparison of Common Ranking Methods
Breznik, Marko, Ge, Yunhui, Bluck, Joseph P., Briem, Hans, Hahn, David F., Christ, Clara D., Mortier, Jérémie, Mobley, David L., Meier, Katharina
Published in ChemMedChem (03.01.2023)
Published in ChemMedChem (03.01.2023)
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Journal Article
Binding Kinetics Survey of the Drugged Kinome
Georgi, Victoria, Schiele, Felix, Berger, Benedict-Tilman, Steffen, Andreas, Marin Zapata, Paula A, Briem, Hans, Menz, Stephan, Preusse, Cornelia, Vasta, James D, Robers, Matthew B, Brands, Michael, Knapp, Stefan, Fernández-Montalván, Amaury
Published in Journal of the American Chemical Society (21.11.2018)
Published in Journal of the American Chemical Society (21.11.2018)
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Journal Article
Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Computational Macrocyclization: From de novo Macrocycle Generation to Binding Affinity Estimation
Wagner, Vincent, Jantz, Linda, Briem, Hans, Sommer, Kai, Rarey, Matthias, Christ, Clara D.
Published in ChemMedChem (22.11.2017)
Published in ChemMedChem (22.11.2017)
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Journal Article
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor
Lefranc, Julien, Schulze, Volker Klaus, Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Balint, Jozsef, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, Bömer, Ulf, Bader, Benjamin, Gradl, Stefan Nikolaus, Nising, Carl Friedrich, von Nussbaum, Franz, Mumberg, Dominik, Panne, Daniel, Wengner, Antje Margret
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
The Lab Oddity Prevails: Discovery of Pan-CDK Inhibitor (R)-S-Cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the Treatment of Cancer
Lücking, Ulrich, Jautelat, Rolf, Krüger, Martin, Brumby, Thomas, Lienau, Philip, Schäfer, Martina, Briem, Hans, Schulze, Julia, Hillisch, Alexander, Reichel, Andreas, Wengner, Antje Margret, Siemeister, Gerhard
Published in ChemMedChem (01.07.2013)
Published in ChemMedChem (01.07.2013)
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Journal Article
Computational Macrocyclization: From denovo Macrocycle Generation to Binding Affinity Estimation
Wagner, Vincent, Jantz, Linda, Briem, Hans, Sommer, Kai, Rarey, Matthias, Christ, Clara D
Published in ChemMedChem (22.11.2017)
Published in ChemMedChem (22.11.2017)
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Journal Article
Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer
Mowat, Jeffrey, Carretero, Rafael, Leder, Gabriele, Aiguabella Font, Nuria, Neuhaus, Roland, Berndt, Sandra, Günther, Judith, Friberg, Anders, Schäfer, Martina, Briem, Hans, Raschke, Marian, Miyatake Ondozabal, Hideki, Buchmann, Bernd, Boemer, Ulf, Kreft, Bertolt, Hartung, Ingo V., Offringa, Rienk
Published in Journal of medicinal chemistry (10.10.2024)
Published in Journal of medicinal chemistry (10.10.2024)
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