Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in Cell metabolism (04.12.2018)
Published in Cell metabolism (04.12.2018)
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Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth
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Published in Molecular cell (15.10.2015)
Published in Molecular cell (15.10.2015)
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LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer
Dupuy, Fanny, Griss, Takla, Blagih, Julianna, Bridon, Gäelle, Avizonis, Daina, Ling, Chen, Dong, Zhifeng, Siwak, Doris R, Annis, Matthew G, Mills, Gordon B, Muller, William J, Siegel, Peter M, Jones, Russell G
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Published in Cancer & metabolism (14.08.2013)
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The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation
Leprivier, Gabriel, Remke, Marc, Rotblat, Barak, Dubuc, Adrian, Mateo, Abigail-Rachele F., Kool, Marcel, Agnihotri, Sameer, El-Naggar, Amal, Yu, Bin, Prakash Somasekharan, Syam, Faubert, Brandon, Bridon, Gaëlle, Tognon, Cristina E., Mathers, Joan, Thomas, Ryan, Li, Amy, Barokas, Adi, Kwok, Brian, Bowden, Mary, Smith, Stephanie, Wu, Xiaochong, Korshunov, Andrey, Hielscher, Thomas, Northcott, Paul A., Galpin, Jason D., Ahern, Christopher A., Wang, Ye, McCabe, Martin G., Collins, V. Peter, Jones, Russell G., Pollak, Michael, Delattre, Olivier, Gleave, Martin E., Jan, Eric, Pfister, Stefan M., Proud, Christopher G., Derry, W. Brent, Taylor, Michael D., Sorensen, Poul H.
Published in Cell (23.05.2013)
Published in Cell (23.05.2013)
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Improvement of Phosphoproteome Analyses Using FAIMS and Decision Tree Fragmentation. Application to the Insulin Signaling Pathway in Drosophila melanogaster S2 Cells
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Published in Journal of proteome research (03.02.2012)
Published in Journal of proteome research (03.02.2012)
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The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer
Audet-Walsh, Étienne, Papadopoli, David J., Gravel, Simon-Pierre, Yee, Tracey, Bridon, Gaëlle, Caron, Maxime, Bourque, Guillaume, Giguère, Vincent, St-Pierre, Julie
Published in Cell reports (Cambridge) (02.02.2016)
Published in Cell reports (Cambridge) (02.02.2016)
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Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling
Papadopoli, David J, Ma, Eric H, Roy, Dominic, Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Jones, Russell G, St-Pierre, Julie
Published in Scientific reports (12.05.2020)
Published in Scientific reports (12.05.2020)
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Synergy between the NAMPT inhibitor GMX1777(8) and pemetrexed in non-small cell lung cancer cells is mediated by PARP activation and enhanced NAD consumption
Chan, Manuel, Gravel, Michel, Bramoullé, Alexandre, Bridon, Gaëlle, Avizonis, Daina, Shore, Gordon C, Roulston, Anne
Published in Cancer research (Chicago, Ill.) (01.11.2014)
Published in Cancer research (Chicago, Ill.) (01.11.2014)
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Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML
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Published in Blood (11.05.2017)
Published in Blood (11.05.2017)
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Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis
Biondini, Marco, Lehuédé, Camille, Tabariès, Sébastien, Annis, Matthew G., Pacis, Alain, Ma, Eric H., Tam, Christine, Hsu, Brian E., Audet-Delage, Yannick, Abu-Thuraia, Afnan, Girondel, Charlotte, Sabourin, Valerie, Totten, Stephanie P., de Sá Tavares Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Guiot, Marie-Christine, St-Pierre, Julie, Ursini-Siegel, Josie, Jones, Russell, Siegel, Peter M.
Published in Redox biology (01.09.2024)
Published in Redox biology (01.09.2024)
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Subcellular phosphoproteomics
Trost, Matthias, Bridon, Gaëlle, Desjardins, Michel, Thibault, Pierre
Published in Mass spectrometry reviews (01.11.2010)
Published in Mass spectrometry reviews (01.11.2010)
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Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Izreig, Said, Gariepy, Alexandra, Kaymak, Irem, Bridges, Hannah R., Donayo, Ariel O., Bridon, Gaëlle, DeCamp, Lisa M., Kitchen-Goosen, Susan M., Avizonis, Daina, Sheldon, Ryan D., Laister, Rob C., Minden, Mark D., Johnson, Nathalie A., Duchaine, Thomas F., Rudoltz, Marc S., Yoo, Sanghee, Pollak, Michael N., Williams, Kelsey S., Jones, Russell G.
Published in Cell reports. Medicine (19.05.2020)
Published in Cell reports. Medicine (19.05.2020)
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Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
Fu, Accalia, Alvarez-Perez, Juan Carlos, Avizonis, Daina, Kin, Tatsuya, Ficarro, Scott B, Choi, Dong Wook, Karakose, Esra, Badur, Mehmet G, Evans, Lindsay, Rosselot, Carolina, Bridon, Gaelle, Bird, Gregory H, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kamphorst, Jurre J, Stewart, Andrew F, James Shapiro, A M, Marto, Jarrod A, Walensky, Loren D, Jones, Russell G, Garcia-Ocana, Adolfo, Danial, Nika N
Published in Nature metabolism (01.05.2020)
Published in Nature metabolism (01.05.2020)
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Translational and HIF-1α-dependent metabolic reprogramming underpin metabolic plasticity and determine responses to kinase inhibitors and biguanides
Hulea, Laura, Gravel, Simon-Pierre, Morita, Masahiro, Cargnello, Marie, Uchenunu, Oro, Im, Young Kyuen, Lehuédé, Camille, Ma, Eric H., Leibovitch, Matthew, McLaughlan, Shannon, Blouin, Marie-José, Parisotto, Maxime, Papavasiliou, Vasilios, Lavoie, Cynthia, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaëlle, Avizonis, Daina, Ferbeyre, Gerardo, Siegel, Peter, Jones, Russell G., Muller, William, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in Cell metabolism (20.09.2018)
Published in Cell metabolism (20.09.2018)
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Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells
Liyanage, Sanduni U., Hurren, Rose, Voisin, Veronique, Xiaoming, Wang, Bridon, Gaëlle, Xu, Changjiang, MacLean, Neil, Siriwardena, Thirushi, Shamas-Din, Aisha, Sriskanthadevan, Shrivani, Minden, Mark D., Bader, Gary D, Laposa, Rebecca, Schimmer, Aaron D.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Translational and HIF1 -dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides
Hulea, Laura, Simon-Pierre Gravel, Morita, Masahiro, Cargnello, Marie, Oro Uchenunu, Young Kyuen Im, Mclaughlan, Shannon, Larsson, Ola, Ohh, Michael, Ferreira, Tiago, Greenwood, Celia, Bridon, Gaelle, Avizonis, Daina, Ursini-Siegel, Josie, St-Pierre, Julie, Pollak, Michael, Topisirovic, Ivan
Published in bioRxiv (08.07.2017)
Published in bioRxiv (08.07.2017)
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Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment
Izreig, Said, Gariepy, Alexandra, Donayo, Ariel O, Bridon, Gaëlle, Avizonis, Daina, Sheldon, Ryan D, Laister, Rob, Minden, Mark D, Johnson, Nathalie A, Williams, Kelsey S, Rudoltz, Marc S, Duchaine, Thomas F, Yoo, Sanghee, Pollak, Michael N, Jones, Russell G
Published in bioRxiv (20.12.2019)
Published in bioRxiv (20.12.2019)
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