A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells
Ladell, Kristin, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James E., Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie, Price, David A., Appay, Victor
Published in Immunity (Cambridge, Mass.) (21.03.2013)
Published in Immunity (Cambridge, Mass.) (21.03.2013)
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Building better chimeric antigen receptors for adoptive T cell therapy
Bridgeman, John S, Hawkins, Robert E, Hombach, Andreas A, Abken, Hinrich, Gilham, David E
Published in Current gene therapy (01.04.2010)
Published in Current gene therapy (01.04.2010)
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Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes
Kalaitsidou, Milena, Moon, Owen R, Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell, Jr, Daniel J, Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E, Hawkins, Robert E, Kueberuwa, Gray, Bridgeman, John S
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope
Cole, David K, Fuller, Anna, Dolton, Garry, Zervoudi, Efthalia, Legut, Mateusz, Miles, Kim, Blanchfield, Lori, Madura, Florian, Holland, Christopher J, Bulek, Anna M, Bridgeman, John S, Miles, John J, Schauenburg, Andrea J A, Beck, Konrad, Evavold, Brian D, Rizkallah, Pierre J, Sewell, Andrew K
Published in Frontiers in immunology (10.11.2017)
Published in Frontiers in immunology (10.11.2017)
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Transgenic T-cell receptor immunotherapy for cancer: building on clinical success
Oppermans, Natasha, Kueberuwa, Gray, Hawkins, Robert E., Bridgeman, John S.
Published in Therapeutic Advances in Vaccines and Immunotherapy (2020)
Published in Therapeutic Advances in Vaccines and Immunotherapy (2020)
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Book Review
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Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells
Pearson, Frances E, Tullett, Kirsteen M, Leal‐Rojas, Ingrid M, Haigh, Oscar L, Masterman, Kelly‐Anne, Walpole, Carina, Bridgeman, John S, McLaren, James E, Ladell, Kristin, Miners, Kelly, Llewellyn‐Lacey, Sian, Price, David A, Tunger, Antje, Schmitz, Marc, Miles, John J, Lahoud, Mireille H, Radford, Kristen J
Published in Clinical & translational immunology (2020)
Published in Clinical & translational immunology (2020)
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Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
Pageon, Sophie V., Tabarin, Thibault, Yamamoto, Yui, Ma, Yuanqing, Nicovich, Philip R., Bridgeman, John S., Cohnen, André, Benzing, Carola, Gao, Yijun, Crowther, Michael D., Tungatt, Katie, Dolton, Garry, Sewell, Andrew K., Price, David A., Acuto, Oreste, Parton, Robert G., Gooding, J. Justin, Rossy, Jérémie, Rossjohn, Jamie, Gaus, Katharina
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2016)
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Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
Spindler, Matthew J., Nelson, Ayla L., Wagner, Ellen K., Oppermans, Natasha, Bridgeman, John S., Heather, James M., Adler, Adam S., Asensio, Michael A., Edgar, Robert C., Lim, Yoong Wearn, Meyer, Everett H., Hawkins, Robert E., Cobbold, Mark, Johnson, David S.
Published in Nature biotechnology (01.05.2020)
Published in Nature biotechnology (01.05.2020)
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CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains
Chancellor, Andrew, Tocheva, Anna S., Cave-Ayland, Chris, Tezera, Liku, White, Andrew, Dulayymi, Juma’a R. Al, Bridgeman, John S., Tews, Ivo, Wilson, Susan, Lissin, Nikolai M., Tebruegge, Marc, Marshall, Ben, Sharpe, Sally, Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Baird, Mark S., Gadola, Stephan, Elkington, Paul, Mansour, Salah
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2017)
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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs
Knezevic, Lea, Wachsmann, Tassilo L.A., Francis, Ore, Dockree, Tamsin, Bridgeman, John S., Wouters, Anne, de Wet, Ben, Cole, David K., Clement, Mathew, McLaren, James E., Gostick, Emma, Ladell, Kristin, Llewellyn-Lacey, Sian, Price, David A., van den Berg, Hugo A., Tabi, Zsuzsanna, Sessions, Richard B., Heemskerk, Mirjam H.M., Wooldridge, Linda
Published in The Journal of biological chemistry (01.08.2023)
Published in The Journal of biological chemistry (01.08.2023)
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CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor
Clement, Mathew, Knezevic, Lea, Dockree, Tamsin, McLaren, James E., Ladell, Kristin, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K., Sewell, Andrew K., Bridgeman, John S., Price, David A., van den Berg, Hugo A., Wooldridge, Linda
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2021)
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Structural and biophysical determinants of αβ T‐cell antigen recognition
Bridgeman, John S., Sewell, Andrew K., Miles, John J., Price, David A., Cole, David K.
Published in Immunology (01.01.2012)
Published in Immunology (01.01.2012)
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Synergistic targeting of breast cancer stem‐like cells by human γδ T cells and CD8+ T cells
Chen, Hung‐Chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A, Gallimore, Awen M, Clarkson, Richard W, Scotet, Emmanuel, Moser, Bernhard, Eberl, Matthias
Published in Immunology and cell biology (01.08.2017)
Published in Immunology and cell biology (01.08.2017)
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426 Anti-folate receptor alpha (FRα) CoStimulatory Antigen Receptor (CoStAR™) drives distinct cytokine-mediated proliferation responses in CD4+ and CD8+ T cells
Sykorova, Martina, Hawkins, Robert E, Dudley, Mark, Kueberuwa, Gray, Bridgeman, John S
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model
Cheadle, Eleanor J, Sheard, Victoria, Rothwell, Dominic G, Bridgeman, John S, Ashton, Garry, Hanson, Vivien, Mansoor, A Wasat, Hawkins, Robert E, Gilham, David E
Published in The Journal of immunology (1950) (15.04.2014)
Published in The Journal of immunology (1950) (15.04.2014)
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Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity
O'Connor, Geraldine M, Vivian, Julian P, Widjaja, Jacqueline M, Bridgeman, John S, Gostick, Emma, Lafont, Bernard A P, Anderson, Stephen K, Price, David A, Brooks, Andrew G, Rossjohn, Jamie, McVicar, Daniel W
Published in The Journal of immunology (1950) (15.03.2014)
Published in The Journal of immunology (1950) (15.03.2014)
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ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells
Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A., Matthews, R. James, Knäuper, Vera, Ager, Ann
Published in Scientific reports (02.04.2019)
Published in Scientific reports (02.04.2019)
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CD8+ T‐cell specificity is compromised at a defined MHCI/CD8 affinity threshold
Dockree, Tamsin, Holland, Christopher J, Clement, Mathew, Ladell, Kristin, McLaren, James E, Berg, Hugo A, Gostick, Emma, L Miners, Kelly, Llewellyn‐Lacey, Sian, Bridgeman, John S, Man, Stephen, Bailey, Mick, Burrows, Scott R, Price, David A, Wooldridge, Linda
Published in Immunology and cell biology (01.01.2017)
Published in Immunology and cell biology (01.01.2017)
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423 Single cell RNA sequencing reveals functionally validated signatures of cytotoxicity in anti-FRα CoStimulatory Antigen Receptor (CoStARTM) activated CD4+ T cells
Baklan, Katrina Sherbina, Sykorova, Martina, Bao, Leyuan, Moon, Owen, Hawkins, Robert E, Dudley, Mark, Kueberuwa, Gray, Yuan, Jinzhou, Bridgeman, John S
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Clinical feasibility and treatment outcomes with nonselected autologous tumor-infiltrating lymphocyte therapy in patients with advanced cutaneous melanoma
Pillai, Manon, Jiang, Yizhou, Lorigan, Paul C, Thistlethwaite, Fiona C, Thomas, Martine, Kirillova, Natalia, Bridgeman, John S, Kueberuwa, Gray, Biswas, Sunetra, Velazquez, Peter, Chonzi, David, Guest, Ryan D, Roberts, Zachary J, Hawkins, Robert E
Published in American journal of cancer research (01.01.2022)
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Published in American journal of cancer research (01.01.2022)
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