E3 ligase ligand chemistries: from building blocks to protein degraders
Sosi, Izidor, Bricelj, Aleša, Steinebach, Christian
Published in Chemical Society reviews (10.05.2022)
Published in Chemical Society reviews (10.05.2022)
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Journal Article
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins
Ng, Yuen Lam Dora, Bricelj, Aleša, Jansen, Jacqueline A., Murgai, Arunima, Peter, Kirsten, Donovan, Katherine A., Gütschow, Michael, Krönke, Jan, Steinebach, Christian, Sosič, Izidor
Published in Journal of medicinal chemistry (13.04.2023)
Published in Journal of medicinal chemistry (13.04.2023)
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Journal Article
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands
Bricelj, Aleša, Dora Ng, Yuen Lam, Ferber, Dominic, Kuchta, Robert, Müller, Sina, Monschke, Marius, Wagner, Karl G, Krönke, Jan, Sosič, Izidor, Gütschow, Michael, Steinebach, Christian
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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Journal Article
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
Steinebach, Christian, Bricelj, Aleša, Murgai, Arunima, Sosič, Izidor, Bischof, Luca, Ng, Yuen Lam Dora, Heim, Christopher, Maiwald, Samuel, Proj, Matic, Voget, Rabea, Feller, Felix, Košmrlj, Janez, Sapozhnikova, Valeriia, Schmidt, Annika, Zuleeg, Maximilian Rudolf, Lemnitzer, Patricia, Mertins, Philipp, Hansen, Finn K., Gütschow, Michael, Krönke, Jan, Hartmann, Marcus D.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
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Journal Article
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers
Vu, Lan Phuong, Diehl, Claudia J., Casement, Ryan, Bond, Adam G., Steinebach, Christian, Strašek, Nika, Bricelj, Aleša, Perdih, Andrej, Schnakenburg, Gregor, Sosič, Izidor, Ciulli, Alessio, Gütschow, Michael
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Journal Article
A Facile Synthesis of Ligands for the von Hippel-Lindau E3 Ligase
Steinebach, Christian, Voell, Sabine Anna, Vu, Lan Phuong, Bricelj, Alesa, Sosic, Izidor, Schnakenburg, Gregor, Gutschow, Michael
Published in Synthesis (Stuttgart) (01.09.2020)
Published in Synthesis (Stuttgart) (01.09.2020)
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Journal Article
Medication review service implementation in community pharmacy settings: Scoping review with focus on implementation studies
Brandt, Jaden, Lê, Mê-Linh, Jantscher, Sonja, Bricelj, Aleša, Louizos, Christopher, Ng, Sheila, Sibley, Kathryn
Published in Research in social and administrative pharmacy (01.07.2020)
Published in Research in social and administrative pharmacy (01.07.2020)
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Journal Article
E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points
Bricelj, Aleša, Steinebach, Christian, Kuchta, Robert, Gütschow, Michael, Sosič, Izidor
Published in Frontiers in chemistry (05.07.2021)
Published in Frontiers in chemistry (05.07.2021)
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Journal Article
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Steinebach, Christian, Ng, Yuen Lam Dora, Sosi, Izidor, Lee, Chih-Shia, Chen, Sirui, Lindner, Stefanie, Vu, Lan Phuong, Bricelj, Aleša, Haschemi, Reza, Monschke, Marius, Steinwarz, Elisabeth, Wagner, Karl G, Bendas, Gerd, Luo, Ji, Gütschow, Michael, Krönke, Jan
Published in Chemical science (Cambridge) (07.04.2020)
Published in Chemical science (Cambridge) (07.04.2020)
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Journal Article
Design, Synthesis, and Evaluation of BCL‐2 Targeting PROTACs
Bricelj, Aleša, Dora Ng, Yuen Lam, Gobec, Martina, Kuchta, Robert, Hu, Wanyi, Javornik, Špela, Rožič, Miha, Gütschow, Michael, Zheng, Guangrong, Krönke, Jan, Steinebach, Christian, Sosič, Izidor
Published in Chemistry : a European journal (12.08.2024)
Published in Chemistry : a European journal (12.08.2024)
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Journal Article
A MedChem toolbox for cereblon-directed PROTACs
Steinebach, Christian, Sosi, Izidor, Lindner, Stefanie, Bricelj, Aleša, Kohl, Franziska, Ng, Yuen Lam Dora, Monschke, Marius, Wagner, Karl G, Krönke, Jan, Gütschow, Michael
Published in MedChemComm (01.06.2019)
Published in MedChemComm (01.06.2019)
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Journal Article
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders† †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0sc00167h
Steinebach, Christian, Ng, Yuen Lam Dora, Sosič, Izidor, Lee, Chih-Shia, Chen, Sirui, Lindner, Stefanie, Vu, Lan Phuong, Bricelj, Aleša, Haschemi, Reza, Monschke, Marius, Steinwarz, Elisabeth, Wagner, Karl G., Bendas, Gerd, Luo, Ji, Gütschow, Michael, Krönke, Jan
Published in Chemical science (Cambridge) (04.03.2020)
Published in Chemical science (Cambridge) (04.03.2020)
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Journal Article
A MedChem toolbox for cereblon-directed PROTACs† †Electronic supplementary information (ESI) available: Fig. S1–S10 and Table S1; biological and chemical methods; synthetic Schemes S1–S8 and procedures; log P, 1H NMR, 13C NMR and MS data. See DOI: 10.1039/c9md00185a
Steinebach, Christian, Sosič, Izidor, Lindner, Stefanie, Bricelj, Aleša, Kohl, Franziska, Ng, Yuen Lam Dora, Monschke, Marius, Wagner, Karl G., Krönke, Jan, Gütschow, Michael
Published in MedChemComm (28.05.2019)
Published in MedChemComm (28.05.2019)
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Journal Article