Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
Elmore, Monica R.P., Najafi, Allison R., Koike, Maya A., Dagher, Nabil N., Spangenberg, Elizabeth E., Rice, Rachel A., Kitazawa, Masashi, Matusow, Bernice, Nguyen, Hoa, West, Brian L., Green, Kim N.
Published in Neuron (Cambridge, Mass.) (16.04.2014)
Published in Neuron (Cambridge, Mass.) (16.04.2014)
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Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Császár, Eszter, Lénárt, Nikolett, Cserép, Csaba, Környei, Zsuzsanna, Fekete, Rebeka, Pósfai, Balázs, Balázsfi, Diána, Hangya, Balázs, Schwarcz, Anett D, Szabadits, Eszter, Szöllősi, Dávid, Szigeti, Krisztián, Máthé, Domokos, West, Brian L, Sviatkó, Katalin, Brás, Ana Rita, Mariani, Jean-Charles, Kliewer, Andrea, Lenkei, Zsolt, Hricisák, László, Benyó, Zoltán, Baranyi, Mária, Sperlágh, Beáta, Menyhárt, Ákos, Farkas, Eszter, Dénes, Ádám
Published in The Journal of experimental medicine (07.03.2022)
Published in The Journal of experimental medicine (07.03.2022)
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Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke
Szalay, Gergely, Martinecz, Bernadett, Lénárt, Nikolett, Környei, Zsuzsanna, Orsolits, Barbara, Judák, Linda, Császár, Eszter, Fekete, Rebeka, West, Brian L., Katona, Gergely, Rózsa, Balázs, Dénes, Ádám
Published in Nature communications (03.05.2016)
Published in Nature communications (03.05.2016)
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Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
Nissen, Jillian C., Thompson, Kaitlyn K., West, Brian L., Tsirka, Stella E.
Published in Experimental neurology (01.09.2018)
Published in Experimental neurology (01.09.2018)
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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
Spangenberg, Elizabeth, Severson, Paul L., Hohsfield, Lindsay A., Crapser, Joshua, Zhang, Jiazhong, Burton, Elizabeth A., Zhang, Ying, Spevak, Wayne, Lin, Jack, Phan, Nicole Y., Habets, Gaston, Rymar, Andrey, Tsang, Garson, Walters, Jason, Nespi, Marika, Singh, Parmveer, Broome, Stephanie, Ibrahim, Prabha, Zhang, Chao, Bollag, Gideon, West, Brian L., Green, Kim N.
Published in Nature communications (21.08.2019)
Published in Nature communications (21.08.2019)
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Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice
Elmore, Monica R. P., Hohsfield, Lindsay A., Kramár, Enikö A., Soreq, Lilach, Lee, Rafael J., Pham, Stephanie T., Najafi, Allison R., Spangenberg, Elizabeth E., Wood, Marcelo A., West, Brian L., Green, Kim N.
Published in Aging cell (01.12.2018)
Published in Aging cell (01.12.2018)
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CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
Zhu, Yu, Knolhoff, Brett L, Meyer, Melissa A, Nywening, Timothy M, West, Brian L, Luo, Jingqin, Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C, DeNardo, David G
Published in Cancer research (Chicago, Ill.) (15.09.2014)
Published in Cancer research (Chicago, Ill.) (15.09.2014)
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Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology
Spangenberg, Elizabeth E, Lee, Rafael J, Najafi, Allison R, Rice, Rachel A, Elmore, Monica R P, Blurton-Jones, Mathew, West, Brian L, Green, Kim N
Published in Brain (London, England : 1878) (01.04.2016)
Published in Brain (London, England : 1878) (01.04.2016)
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Activated microglia drive demyelination via CSF1R signaling
Marzan, Dave E., Brügger‐Verdon, Valérie, West, Brian L., Liddelow, Shane, Samanta, Jayshree, Salzer, James L.
Published in Glia (01.06.2021)
Published in Glia (01.06.2021)
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CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
JINGYING XU, ESCAMILLA, Jemima, MOK, Stephen, DAVID, John, PRICEMAN, Saul, WEST, Brian, BOLLAG, Gideon, MCBRIDE, William, WU, Lily
Published in Cancer research (Chicago, Ill.) (01.05.2013)
Published in Cancer research (Chicago, Ill.) (01.05.2013)
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Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy
MOK, Stephen, KOYA, Richard C, TSUI, Christopher, JINGYING XU, ROBERT, Lidia, WU, Lily, GRAEBER, Thomas G, WEST, Brian L, BOLLAG, Gideon, RIBAS, Antoni
Published in Cancer research (Chicago, Ill.) (2014)
Published in Cancer research (Chicago, Ill.) (2014)
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Microglial repopulation resolves inflammation and promotes brain recovery after injury
Rice, Rachel A., Pham, Jason, Lee, Rafael J., Najafi, Allison R., West, Brian L., Green, Kim N.
Published in Glia (01.06.2017)
Published in Glia (01.06.2017)
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Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
Butowski, Nicholas, Colman, Howard, De Groot, John F, Omuro, Antonio M, Nayak, Lakshmi, Wen, Patrick Y, Cloughesy, Timothy F, Marimuthu, Adhirai, Haidar, Sam, Perry, Arie, Huse, Jason, Phillips, Joanna, West, Brian L, Nolop, Keith B, Hsu, Henry H, Ligon, Keith L, Molinaro, Annette M, Prados, Michael
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.04.2016)
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Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization
Stafford, Jason H, Hirai, Takahisa, Deng, Lei, Chernikova, Sophia B, Urata, Kimiko, West, Brian L, Brown, J Martin
Published in Neuro-oncology (Charlottesville, Va.) (01.06.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.06.2016)
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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David
Published in Cancer research (Chicago, Ill.) (01.02.2013)
Published in Cancer research (Chicago, Ill.) (01.02.2013)
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Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
Dagher, Nabil N, Najafi, Allison R, Kayala, Kara M Neely, Elmore, Monica R P, White, Terra E, Medeiros, Rodrigo, West, Brian L, Green, Kim N
Published in Journal of neuroinflammation (01.08.2015)
Published in Journal of neuroinflammation (01.08.2015)
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Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations
Groh, Janos, Klein, Dennis, Berve, Kristina, West, Brian L., Martini, Rudolf
Published in Glia (01.02.2019)
Published in Glia (01.02.2019)
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Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling
Coniglio, Salvatore J, Eugenin, Eliseo, Dobrenis, Kostantin, Stanley, E Richard, West, Brian L, Symons, Marc H, Segall, Jeffrey E
Published in Molecular medicine (Cambridge, Mass.) (09.05.2012)
Published in Molecular medicine (Cambridge, Mass.) (09.05.2012)
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Elimination of microglia improves cognitive function following cranial irradiation
Acharya, Munjal M., Green, Kim N., Allen, Barrett D., Najafi, Allison R., Syage, Amber, Minasyan, Harutyun, Le, Mi T., Kawashita, Takumi, Giedzinski, Erich, Parihar, Vipan K., West, Brian L., Baulch, Janet E., Limoli, Charles L.
Published in Scientific reports (12.08.2016)
Published in Scientific reports (12.08.2016)
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