NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
Rapoport, Aaron P, Stadtmauer, Edward A, Binder-Scholl, Gwendolyn K, Goloubeva, Olga, Vogl, Dan T, Lacey, Simon F, Badros, Ashraf Z, Garfall, Alfred, Weiss, Brendan, Finklestein, Jeffrey, Kulikovskaya, Irina, Sinha, Sanjoy K, Kronsberg, Shari, Gupta, Minnal, Bond, Sarah, Melchiori, Luca, Brewer, Joanna E, Bennett, Alan D, Gerry, Andrew B, Pumphrey, Nicholas J, Williams, Daniel, Tayton- Martin, Helen K, Ribeiro, Lilliam, Holdich, Tom, Yanovich, Saul, Hardy, Nancy, Yared, Jean, Kerr, Naseem, Philip, Sunita, Westphal, Sandra, Siegel, Don L, Levine, Bruce L, Jakobsen, Bent K, Kalos, Michael, June, Carl H
Published in Nature medicine (01.08.2015)
Published in Nature medicine (01.08.2015)
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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
Linette, Gerald P., Stadtmauer, Edward A., Maus, Marcela V., Rapoport, Aaron P., Levine, Bruce L., Emery, Lyndsey, Litzky, Leslie, Bagg, Adam, Carreno, Beatriz M., Cimino, Patrick J., Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Gerry, Andrew B., Pumphrey, Nick J., Bennett, Alan D., Brewer, Joanna E., Dukes, Joseph, Harper, Jane, Tayton-Martin, Helen K., Jakobsen, Bent K., Hassan, Namir J., Kalos, Michael, June, Carl H.
Published in Blood (08.08.2013)
Published in Blood (08.08.2013)
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Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
Cameron, Brian J, Gerry, Andrew B, Dukes, Joseph, Harper, Jane V, Kannan, Vivekanandan, Bianchi, Frayne C, Grand, Francis, Brewer, Joanna E, Gupta, Minnal, Plesa, Gabriela, Bossi, Giovanna, Vuidepot, Annelise, Powlesland, Alex S, Legg, Alison, Adams, Katherine J, Bennett, Alan D, Pumphrey, Nicholas J, Williams, Daniel D, Binder-Scholl, Gwendolyn, Kulikovskaya, Irina, Levine, Bruce L, Riley, James L, Varela-Rohena, Angel, Stadtmauer, Edward A, Rapoport, Aaron P, Linette, Gerald P, June, Carl H, Hassan, Namir J, Kalos, Michael, Jakobsen, Bent K
Published in Science translational medicine (07.08.2013)
Published in Science translational medicine (07.08.2013)
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Engineering Cancer Antigen-Specific T Cells to Overcome the Immunosuppressive Effects of TGF-β
Silk, Jonathan D, Abbott, Rachel J M, Adams, Katherine J, Bennett, Alan D, Brett, Sara, Cornforth, Terri V, Crossland, Katherine L, Figueroa, David J, Jing, Junping, O'Connor, Caitriona, Pachnio, Annette, Patasic, Lea, Peredo, Carlos E, Quattrini, Adriano, Quinn, Laura L, Rust, Alistair G, Saini, Manoj, Sanderson, Joseph P, Steiner, Dylan, Tavano, Barbara, Viswanathan, Preetha, Wiedermann, Guy E, Wong, Ryan, Jakobsen, Bent K, Britten, Cedrik M, Gerry, Andrew B, Brewer, Joanna E
Published in The Journal of immunology (1950) (01.01.2022)
Published in The Journal of immunology (1950) (01.01.2022)
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Quantifying and Imaging NY-ESO-1/LAGE-1-Derived Epitopes on Tumor Cells Using High Affinity T Cell Receptors
Purbhoo, Marco A, Sutton, Deborah H, Brewer, Joanna E, Mullings, Rebecca E, Hill, Maxine E, Mahon, Tara M, Karbach, Julia, Jager, Elke, Cameron, Brian J, Lissin, Nikolai, Vyas, Paresh, Chen, Ji-Li, Cerundolo, Vincenzo, Jakobsen, Bent K
Published in Journal of Immunology (15.06.2006)
Published in Journal of Immunology (15.06.2006)
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The HLA A0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor
Purbhoo, Marco A, Li, Yi, Sutton, Deborah H, Brewer, Joanna E, Gostick, Emma, Bossi, Giovanna, Laugel, Bruno, Moysey, Ruth, Baston, Emma, Liddy, Nathaniel, Cameron, Brian, Bennett, Alan D, Ashfield, Rebecca, Milicic, Anita, Price, David A, Classon, Brendan J, Sewell, Andrew K, Jakobsen, Bent K
Published in Molecular cancer therapeutics (01.07.2007)
Published in Molecular cancer therapeutics (01.07.2007)
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Target discovery for T cell therapy: next steps to advance Immunotherapies
Bot, Adrian, Brewer, Joanna E, Eshhar, Zelig, Frankel, Stanley R, Hickman, Emma, Jungbluth, Achim A, Morgan, Richard, Peretz, Yoav, Radvanyi, Laszlo, Ramos, Carlos A, Robbins, Paul F, Wucherpfennig, Kai W
Published in Journal for immunotherapy of cancer (21.07.2015)
Published in Journal for immunotherapy of cancer (21.07.2015)
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The HLA A0201–restricted hTERT540–548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor
Purbhoo, Marco A., Li, Yi, Sutton, Deborah H., Brewer, Joanna E., Gostick, Emma, Bossi, Giovanna, Laugel, Bruno, Moysey, Ruth, Baston, Emma, Liddy, Nathaniel, Cameron, Brian, Bennett, Alan D., Ashfield, Rebecca, Milicic, Anita, Price, David A., Classon, Brendan J., Sewell, Andrew K., Jakobsen, Bent K.
Published in Molecular cancer therapeutics (01.07.2007)
Published in Molecular cancer therapeutics (01.07.2007)
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Journal Article
High affinity soluble ILT2 receptor: a potent inhibitor of CD8+ T cell activation
Moysey, Ruth K., Li, Yi, Paston, Samantha J., Baston, Emma E., Sami, Malkit S., Cameron, Brian J., Gavarret, Jessie, Todorov, Penio, Vuidepot, Annelise, Dunn, Steven M., Pumphrey, Nicholas J., Adams, Katherine J., Yuan, Fang, Dennis, Rebecca E., Sutton, Deborah H., Johnson, Andy D., Brewer, Joanna E., Ashfield, Rebecca, Lissin, Nikolai M., Jakobsen, Bent K.
Published in Protein & cell (01.12.2010)
Published in Protein & cell (01.12.2010)
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Journal Article
High Affinity T Cell Receptors as Therapeutic Agents
Ashfield, Rebecca, Senior Research Project Manager, Avidex Ltd, Abingdon, Oxfordshire, England, Sutton, Deborah, Group Leader, Cell Biology, Avidex Ltd, Abingdon, Oxfordshire, England, Bossi, Giovanna, Senior Scientist, Avidex Ltd, Abingdon, Oxfordshire, England, Brewer, Joanna, Group Leader, Cell biology, Avidex Ltd, Abingdon, Oxfordshire, England, Purbhoo, Marco, Research Associate, Division of Molecular and Cell Biology, London, Dennis, Rebecca, Senior Scientist, Avidex Ltd, Abingdon, Oxfordshire, England, Karbach, Julia, Researcher, Ludwig Institute, Frankfurt, Germany, Mahon, Tara, Senior Scientist, Avidex Ltd, Abingdon, Oxfordshire, England, Cameron, Brian, Senior Scientist, Avidex Ltd, Abingdon, Oxfordshire, England, Jakobsen, Bent, Senior Vice President, Research, Avidex Ltd, Abingdon, Oxfordshire, England
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
Published in Clinical immunology (Orlando, Fla.) (01.01.2007)
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A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics
Meyer, Miriam, Mahr, Andrea, Brewer, Joanna, Daniel, Volker, Dell‘Aringa, Justine, Goldstone, Tony, Hersey, Sarah, Johnston, Ian, Larson, Pamela, Loveridge, Michael, MacBeath, Gavin, Moyer, Mark, Nagorsen, Dirk, Papa, Sophie, Peiser, Leanne, Ranade, Koustubh, Rizzi, Ruben, Roers, Axel, Schendel, Dolores, Sivakumar, Pallavur, Tran, Eric, Türeci, Özlem, Weigand, Luise, Wennborg, Anders, Williams, Dennis, Yee, Cassian, Britten, Cedrik M.
Published in Nature reviews. Drug discovery (01.01.2024)
Published in Nature reviews. Drug discovery (01.01.2024)
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Abstract 2281: DNA methyl transferase inhibitors (DNMTis) upregulate NY-ESO expression in several human primary cells: implications for co-therapy with engineered adoptive T-cell therapies
Laugel, Bruno, Sevko, Alexandra, Howe, Karen, Ferjentsik, Zoltan, Ferronha, Tiago, Maroto, Miguel, Brewer, Joanna, Jakobsen, Bent, Binder-Scholl, Gwendolyn
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 2801: The use of induced pluripotent stem (iPS) cells for the safety testing of enhanced affinity TCR-transduced T cells
Adams, Katherine J., Gerry, Andrew B., Brewer, Joanna E., Pumphrey, Nicholas J., Bennett, Alan D., Jakobsen, Bent K.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Abstract 4701: NY-ESO T cells administered post ASCT for MM exhibit extended functionality without exhaustion in a natural pattern of effector and memory programming
Rapoport, Aaron, Stadtmauer, Edward, Melchiori, Luca, Wong, Ryan, Davila, Eduardo, Binder-Scholl, Gwendolyn, Holdich, Tom, Vogl, Dan, Weiss, Brendan, Finkelstein, Jeffrey, Lacey, Simon, Bond, Sarah, Fortin, Marylene, Peretz, Yoav, Brewer, Joanna, Bennett, Alan, Gerry, Andrew, Pumphrey, Nick, Tayton-Martin, Helen, Ribeiro, Lilliam, Badros, Ashraf, Yanovich, Saul, Hardy, Nancy, Yared, Jean, Kerr, Naseem, Philip, Sunita, Wesphal, Sandra, Levine, Bruce L., June, Carl, Kalos, Michael, Jakobsen, Bent
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Engineered T-Cells Expressing An HLA-Restricted Affinity-Enhanced TCR In Advanced Multiple Myeloma Patients Post Auto-SCT Engraft and Are Associated With Encouraging Post Auto-SCT Responses
Rapoport, Aaron P., Stadtmauer, Edward A., Vogl, Dan T., Weiss, Brendan M, Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Finklestein, Jeffrey, Kulikovskaya, Irina, Gupta, Minnal, Brewer, Joanna E., Bennett, Alan D., Gerry, Andrew B., Pumphrey, Nicholas J., Tayton-Martin, Helen K., Ribeiro, Lilliam C., Badros, Ashraf, Yanovich, Saul, Akpek, Gorgun, Kerr, Naseem, Philip, Sunita, Westphal, Sandra, Levine, Bruce L., Jakobsen, Bent K., Kalos, Michael, June, Carl H.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Abstract 4575: Correlates of clinical response following autologous stem cell transplant and adoptive immunotherapy with engineered T cells expressing an affinity-enhanced T cell receptor in patients with mutliple myeloma
Rapoport, Aaron P., Stadtmauer, Edward A., Vogl, Dan T., Weiss, Brendan, Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Finkelstein, Jeffrey, Kulikovskaya, Irina, Gupta, Minnal, Suppa, Erica, Mikheeva, Tatiana, Brewer, Joanna E., Bennett, Alan D., Gerry, Andrew B., Pumphrey, Nick J., Tayton-Martin, Helen K., Ribeiro, Lilliam, Veloso, Elizabeth, Zheng, Zhaohui, Bados, Ashraf Z., Yanovich, Saul, Akpek, Gorgun, Dengel, Karen, Kerr, Naseem, Philip, Sunita, Betts, Kelly-Marie, Westphal, Sandra, Levine, Bruce L., Jakobsen, Bent K., June, Carl H., Kalos, Michael
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Prolonged T Cell Persistence, Homing to Marrow and Selective Targeting of Antigen Positive Tumor in Multiple Myeloma Patients Following Adoptive Transfer of T Cells Genetically Engineered to Express an Affinity-Enhanced T Cell Receptor Against the Cancer Testis Antigens NY-ESO-1 and Lage-1
Kalos, Michael, Rapoport, Aaron P., Stadtmauer, Edward A., Vogl, Dan T., Weiss, Brendan M, Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Kulikovskaya, Irina, Gupta, Minnal, Macatee, Timothy L, Finklestein, Jeffrey M, Brewer, Joanna E., Bennett, Alan D., Gerry, Andrew B., Pumphrey, Nick J., Tayton-Martin, Helen K., Veloso, Elizabeth, Zheng, Zhaohui, Badros, Ashraf Z., Yanovich, Saul, Akpek, Gorgun, McConville, Holly, Philip, Sunita, Levine, Bruce L., Jakobsen, Bent K., June, Carl H.
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Adoptive Transfer of Gene-Modified T-Cells Engineered to Express High-Affinity TCRs for Cancer-Testis Antigens (CTAs) NY-ESO-1 or Lage-1, in MM Patients Post Auto-SCT
Rapoport, Aaron P., Stadtmauer, Edward A., Vogl, Dan T., Weiss, Brendan M, Binder-Scholl, Gwendolyn K., Brewer, Joanna E., Bennett, Alan D., Gerry, Andrew B., Pumphrey, Nick J., Smethurst, Dominic P., Tayton-Martin, Helen K., Lilliam, Ribeiro C., Veloso, Elizabeth, Zheng, Zhaohui, Badros, Ashraf Z., Yanovich, Saul, Akpek, Gorgun, McConville, Holly, Kerr, Naseem, Philip, Sunita, Betts, Kelly-Marie, Westphal, Sandra, Kalos, Michael, Levine, Bruce L., Jakobsen, Bent K., June, Carl H.
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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