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A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
Sey, Nancy Y. A., Hu, Benxia, Mah, Won, Fauni, Harper, McAfee, Jessica Caitlin, Rajarajan, Prashanth, Brennand, Kristen J., Akbarian, Schahram, Won, Hyejung
Published in Nature neuroscience (01.04.2020)
Published in Nature neuroscience (01.04.2020)
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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Xu, Miao, Lee, Emily M, Wen, Zhexing, Cheng, Yichen, Huang, Wei-Kai, Qian, Xuyu, TCW, Julia, Kouznetsova, Jennifer, Ogden, Sarah C, Hammack, Christy, Jacob, Fadi, Nguyen, Ha Nam, Itkin, Misha, Hanna, Catherine, Shinn, Paul, Allen, Chase, Michael, Samuel G, Simeonov, Anton, Huang, Wenwei, Christian, Kimberly M, Goate, Alison, Brennand, Kristen J, Huang, Ruili, Xia, Menghang, Ming, Guo-li, Zheng, Wei, Song, Hongjun, Tang, Hengli
Published in Nature medicine (01.10.2016)
Published in Nature medicine (01.10.2016)
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Synergistic effects of common schizophrenia risk variants
Schrode, Nadine, Ho, Seok-Man, Yamamuro, Kazuhiko, Dobbyn, Amanda, Huckins, Laura, Matos, Marliette R., Cheng, Esther, Deans, P. J. Michael, Flaherty, Erin, Barretto, Natalie, Topol, Aaron, Alganem, Khaled, Abadali, Sonya, Gregory, James, Hoelzli, Emily, Phatnani, Hemali, Singh, Vineeta, Girish, Deeptha, Aronow, Bruce, Mccullumsmith, Robert, Hoffman, Gabriel E., Stahl, Eli A., Morishita, Hirofumi, Sklar, Pamela, Brennand, Kristen J.
Published in Nature genetics (01.10.2019)
Published in Nature genetics (01.10.2019)
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Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
Hoffman, Gabriel E., Hartley, Brigham J., Flaherty, Erin, Ladran, Ian, Gochman, Peter, Ruderfer, Douglas M., Stahl, Eli A., Rapoport, Judith, Sklar, Pamela, Brennand, Kristen J.
Published in Nature communications (20.12.2017)
Published in Nature communications (20.12.2017)
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Mosaic Copy Number Variation in Human Neurons
McConnell, Michael J., Lindberg, Michael R., Brennend, Kristen J., Piper, Julia C., Voet, Thierry, Cowing-Zitron, Chris, Shumilina, Svetlana, Lasken, Roger S., Vermeesch, Joris R., Hall, Ira M., Gage, Fred H.
Published in Science (American Association for the Advancement of Science) (01.11.2013)
Published in Science (American Association for the Advancement of Science) (01.11.2013)
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Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders
Hashimoto-Torii, Kazue, Torii, Masaaki, Fujimoto, Mitsuaki, Nakai, Akira, El Fatimy, Rachid, Mezger, Valerie, Ju, Min J., Ishii, Seiji, Chao, Shih-hui, Brennand, Kristen J., Gage, Fred H., Rakic, Pasko
Published in Neuron (Cambridge, Mass.) (07.05.2014)
Published in Neuron (Cambridge, Mass.) (07.05.2014)
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Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs
Halpern, Madeline, Brennand, Kristen J., Gregory, James
Published in Neurobiology of disease (01.12.2019)
Published in Neurobiology of disease (01.12.2019)
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Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression
Issler, Orna, van der Zee, Yentl Y., Ramakrishnan, Aarthi, Wang, Junshi, Tan, Chunfeng, Loh, Yong-Hwee E., Purushothaman, Immanuel, Walker, Deena M., Lorsch, Zachary S., Hamilton, Peter J., Peña, Catherine J., Flaherty, Erin, Hartley, Brigham J., Torres-Berrío, Angélica, Parise, Eric M., Kronman, Hope, Duffy, Julia E., Estill, Molly S., Calipari, Erin S., Labonté, Benoit, Neve, Rachael L., Tamminga, Carol A., Brennand, Kristen J., Dong, Yan, Shen, Li, Nestler, Eric J.
Published in Neuron (Cambridge, Mass.) (17.06.2020)
Published in Neuron (Cambridge, Mass.) (17.06.2020)
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An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells
TCW, Julia, Wang, Minghui, Pimenova, Anna A., Bowles, Kathryn R., Hartley, Brigham J., Lacin, Emre, Machlovi, Saima I., Abdelaal, Rawan, Karch, Celeste M., Phatnani, Hemali, Slesinger, Paul A., Zhang, Bin, Goate, Alison M., Brennand, Kristen J.
Published in Stem cell reports (08.08.2017)
Published in Stem cell reports (08.08.2017)
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Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
Wang, Minghui, Roussos, Panos, McKenzie, Andrew, Zhou, Xianxiao, Kajiwara, Yuji, Brennand, Kristen J., De Luca, Gabriele C., Crary, John F., Casaccia, Patrizia, Buxbaum, Joseph D., Ehrlich, Michelle, Gandy, Sam, Goate, Alison, Katsel, Pavel, Schadt, Eric, Haroutunian, Vahram, Zhang, Bin
Published in Genome medicine (01.11.2016)
Published in Genome medicine (01.11.2016)
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Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome
Rahman, Samir, Dong, Pengfei, Apontes, Pasha, Fernando, Michael B, Kosoy, Roman, Townsley, Kayla G, Girdhar, Kiran, Bendl, Jaroslav, Shao, Zhiping, Misir, Ruth, Tsankova, Nadia, Kleopoulos, Steven P, Brennand, Kristen J, Fullard, John F, Roussos, Panos
Published in Nucleic acids research (10.11.2023)
Published in Nucleic acids research (10.11.2023)
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The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Jiang, Yan, Loh, Yong-Hwee Eddie, Rajarajan, Prashanth, Hirayama, Teruyoshi, Liao, Will, Kassim, Bibi S, Javidfar, Behnam, Hartley, Brigham J, Kleofas, Lisa, Park, Royce B, Labonte, Benoit, Ho, Seok-Man, Chandrasekaran, Sandhya, Do, Catherine, Ramirez, Brianna R, Peter, Cyril J, C W, Julia T, Safaie, Brian M, Morishita, Hirofumi, Roussos, Panos, Nestler, Eric J, Schaefer, Anne, Tycko, Benjamin, Brennand, Kristen J, Yagi, Takeshi, Shen, Li, Akbarian, Schahram
Published in Nature genetics (01.08.2017)
Published in Nature genetics (01.08.2017)
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Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
Topol, Aaron, Zhu, Shijia, Hartley, Brigham J., English, Jane, Hauberg, Mads E., Tran, Ngoc, Rittenhouse, Chelsea Ann, Simone, Anthony, Ruderfer, Douglas M., Johnson, Jessica, Readhead, Ben, Hadas, Yoav, Gochman, Peter A., Wang, Ying-Chih, Shah, Hardik, Cagney, Gerard, Rapoport, Judith, Gage, Fred H., Dudley, Joel T., Sklar, Pamela, Mattheisen, Manuel, Cotter, David, Fang, Gang, Brennand, Kristen J.
Published in Cell reports (Cambridge) (03.05.2016)
Published in Cell reports (Cambridge) (03.05.2016)
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Expression-based drug screening of neural progenitor cells from individuals with schizophrenia
Readhead, Benjamin, Hartley, Brigham J., Eastwood, Brian J., Collier, David A., Evans, David, Farias, Richard, He, Ching, Hoffman, Gabriel, Sklar, Pamela, Dudley, Joel T., Schadt, Eric E., Savić, Radoslav, Brennand, Kristen J.
Published in Nature communications (24.10.2018)
Published in Nature communications (24.10.2018)
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Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Farrelly, Lorna A., Zheng, Shuangping, Schrode, Nadine, Topol, Aaron, Bhanu, Natarajan V., Bastle, Ryan M., Ramakrishnan, Aarthi, Chan, Jennifer C, Cetin, Bulent, Flaherty, Erin, Shen, Li, Gleason, Kelly, Tamminga, Carol A., Garcia, Benjamin A., Li, Haitao, Brennand, Kristen J., Maze, Ian
Published in Nature communications (22.04.2022)
Published in Nature communications (22.04.2022)
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Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk
Powell, Samuel K., O’Shea, Callan, Townsley, Kayla, Prytkova, Iya, Dobrindt, Kristina, Elahi, Rahat, Iskhakova, Marina, Lambert, Tova, Valada, Aditi, Liao, Will, Ho, Seok-Man, Slesinger, Paul A., Huckins, Laura M., Akbarian, Schahram, Brennand, Kristen J.
Published in Molecular psychiatry (01.05.2023)
Published in Molecular psychiatry (01.05.2023)
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