Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review
Loh, Hui-Yi, Norman, Brendan P, Lai, Kok-Song, Cheng, Wan-Hee, Nik Abd Rahman, Nik Mohd Afizan, Mohamed Alitheen, Noorjahan Banu, Osman, Mohd Azuraidi
Published in International journal of molecular sciences (29.03.2023)
Published in International journal of molecular sciences (29.03.2023)
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Journal Article
Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism
Norman, Brendan P., Davison, Andrew S., Hughes, Juliette H., Sutherland, Hazel, Wilson, Peter JM, Berry, Neil G., Hughes, Andrew T., Milan, Anna M., Jarvis, Jonathan C., Roberts, Norman B., Ranganath, Lakshminarayan R., Bou-Gharios, George, Gallagher, James A.
Published in Genes & diseases (01.07.2022)
Published in Genes & diseases (01.07.2022)
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Journal Article
Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria
Davison, Andrew S, Norman, Brendan P, Sutherland, Hazel, Milan, Anna M, Gallagher, James A, Jarvis, Jonathan C, Ranganath, Lakshminarayan R
Published in Metabolites (25.05.2022)
Published in Metabolites (25.05.2022)
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Journal Article
Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways
Haaike, Colemonts-Vroninks, Brendan, Norman P., Sven, Van Laere, Andrew, Davison S., Lionel, Marcélis, Georges, Casimir, Philippe, Goyens, Paul, Claes, Dimitri, De Bundel, Geert, Martens, Rao, Ranganath Lakshminarayan, Tamara, Vanhaecke, James A, Gallagher, Joery, De Kock
Published in Genes & diseases (01.09.2023)
Published in Genes & diseases (01.09.2023)
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Journal Article
Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment
Ranganath, Lakshminarayan R, Milan, Anna M, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A
Published in Metabolites (01.08.2022)
Published in Metabolites (01.08.2022)
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Journal Article
Increased prevalence of Parkinson's disease in alkaptonuria
Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Janssen, Mirian C. H., Lock, Edward, Bou‐Gharios, George, Gallagher, James A.
Published in JIMD reports (01.07.2023)
Published in JIMD reports (01.07.2023)
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Journal Article
Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria
Ranganath, Lakshminarayan R, Hughes, Andrew T, Davison, Andrew S, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P, Bou-Gharios, George, Gallagher, James A, Milan, Anna M
Published in Metabolites (29.09.2022)
Published in Metabolites (29.09.2022)
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Journal Article
Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria—An approach using statistical modelling
Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Norman, Brendan P., Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A., Jackson, Richard
Published in JIMD reports (01.01.2022)
Published in JIMD reports (01.01.2022)
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Journal Article
Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria
Norman, Brendan P, Davison, Andrew S, Hickton, Bryony, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Wilson, Peter J. M, Sutherland, Hazel, Hughes, Juliette H, Roberts, Norman B, Bou-Gharios, George, Gallagher, James A, Ranganath, Lakshminarayan R
Published in Metabolites (29.09.2022)
Published in Metabolites (29.09.2022)
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Journal Article
Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review
Ranganath, Lakshminarayan R., Norman, Brendan P., Gallagher, James A.
Published in Journal of inherited metabolic disease (01.09.2019)
Published in Journal of inherited metabolic disease (01.09.2019)
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Journal Article
Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS
Davison, Andrew S., Norman, Brendan P., Ross, Gordon A., Hughes, Andrew T., Khedr, Milad, Milan, Anna M., Gallagher, James A., Ranganath, Lakshminarayan R.
Published in JIMD reports (01.07.2019)
Published in JIMD reports (01.07.2019)
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Journal Article
Pigmentation Chemistry and Radical‐Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage
Chow, Wing Ying, Norman, Brendan P., Roberts, Norman B., Ranganath, Lakshminarayan R., Teutloff, Christian, Bittl, Robert, Duer, Melinda J., Gallagher, James A., Oschkinat, Hartmut
Published in Angewandte Chemie International Edition (13.07.2020)
Published in Angewandte Chemie International Edition (13.07.2020)
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Journal Article
Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial
Ranganath, Lakshminarayan R, Psarelli, Eftychia Eirini, Arnoux, Jean-Baptiste, Braconi, Daniela, Briggs, Michael, Bröijersén, Anders, Loftus, Nadia, Bygott, Helen, Cox, Trevor F, Davison, Andrew S, Dillon, Jane P, Fisher, Michael, FitzGerald, Richard, Genovese, Federica, Glasova, Helena, Hall, Anthony K, Hughes, Andrew T, Hughes, Juliette H, Imrich, Richard, Jarvis, Jonathan C, Khedr, Milad, Laan, Dinny, Le Quan Sang, Kim-Hanh, Luangrath, Emily, Lukáčová, Ol'ga, Milan, Anna M, Mistry, Alpesh, Mlynáriková, Vanda, Norman, Brendan P, Olsson, Birgitta, Rhodes, Nicholas P, Rovenský, Jozef, Rudebeck, Mattias, Santucci, Annalisa, Shweihdi, Ella, Scott, Ciarán, Sedláková, Jana, Sireau, Nicolas, Stančík, Roman, Szamosi, Johan, Taylor, Sophie, van Kan, Christa, Vinjamuri, Sobhan, Vrtíková, Eva, Webb, Chris, West, Elizabeth, Záňová, Elizabeth, Zatkova, Andrea, Gallagher, James A
Published in The lancet. Diabetes & endocrinology (01.09.2020)
Published in The lancet. Diabetes & endocrinology (01.09.2020)
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Journal Article
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hughes, Juliette H, Liu, Ke, Plagge, Antonius, Wilson, Peter J M, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao, Ranganath, Lakshminarayan R, Gallagher, James A, Bou-Gharios, George
Published in Human molecular genetics (01.12.2019)
Published in Human molecular genetics (01.12.2019)
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Journal Article
A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria
Norman, Brendan P, Davison, Andrew S, Ross, Gordon A, Milan, Anna M, Hughes, Andrew T, Sutherland, Hazel, Jarvis, Jonathan C, Roberts, Norman B, Gallagher, James A, Ranganath, Lakshminarayan R
Published in Clinical chemistry (Baltimore, Md.) (01.04.2019)
Published in Clinical chemistry (Baltimore, Md.) (01.04.2019)
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Journal Article
Nitisinone causes acquired tyrosinosis in alkaptonuria
Khedr, Milad, Cooper, Maggie S., Hughes, Andrew T., Milan, Anna M., Davison, Andrew S., Norman, Brendan P., Sutherland, Hazel, Jarvis, Jonathan C., Fitzgerald, Richard, Markinson, Louise, Psarelli, Eftychia‐Eirini, Ghane, Parisa, Deutz, Nicolaas E. P., Gallagher, James A., Ranganath, Lakshminarayan R.
Published in Journal of inherited metabolic disease (01.09.2020)
Published in Journal of inherited metabolic disease (01.09.2020)
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Journal Article
Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria
Ranganath, Lakshminarayan R., Milan, Anna M., Hughes, Andrew T., Khedr, Milad, Davison, Andrew S., Shweihdi, Ella, Norman, Brendan P., Hughes, Juliette H., Bygott, Helen, Luangrath, Emily, Fitzgerald, Richard, Psarelli, Eftychia E., Kan, Christa, Laan, Dinny, Olsson, Birgitta, Rudebeck, Mattias, Mankowitz, Louise, Sireau, Nicolas, Arnoux, Jean‐Baptiste, Le Quan Sang, Kim‐Hanh, Jarvis, Jonathan C., Genovese, Federica, Braconi, Daniela, Santucci, Annalisa, Zatkova, Andrea, Glasova, Helena, Stančík, Roman, Imrich, Richard, Rhodes, Nicholas P., Gallagher, James A.
Published in Journal of inherited metabolic disease (01.07.2020)
Published in Journal of inherited metabolic disease (01.07.2020)
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Journal Article